Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

scientific journal article

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PNAS..11013091B
P356DOI10.1073/PNAS.1302507110
P3181OpenCitations bibliographic resource ID2857988
P932PMC publication ID3740859
P698PubMed publication ID23878224

P50authorCarla V. RothlinQ41071298
P2093author name stringSourav Ghosh
Nicola Gagliani
Leonel Joannas
Lidia Bosurgi
Victor Delgado Cuevas
Carmen J. Booth
Edward T. Schmid
Jochem H. Bernink
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseQ24310364
Cloning and mRNA expression analysis of a novel human protooncogene, c-merQ24319969
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ28585555
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
Alternative activation of macrophages: an immunologic functional perspectiveQ29614353
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerQ29614594
Fate mapping analysis reveals that adult microglia derive from primitive macrophagesQ29616177
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
A lineage of myeloid cells independent of Myb and hematopoietic stem cellsQ29620147
Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestionQ30408786
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.Q30539324
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune responseQ33595572
Inflammation and oncogenesis: a vicious connectionQ33653294
Immunobiology of the TAM receptorsQ33796991
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.Q34411406
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinomaQ34515144
Ulcerative colitis and colorectal cancer. A population-based studyQ34634203
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytesQ34650719
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studiesQ34772160
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancerQ34794927
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationQ35083309
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivityQ35111750
Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinomaQ35486521
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cellsQ35615917
Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumorsQ35927501
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerQ36128435
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK inductionQ36301713
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceQ36597042
Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeuticsQ37203741
A protective function for interleukin 17A in T cell-mediated intestinal inflammationQ37260173
Organ- and cell-type specific delivery of kinase inhibitors: a novel approach in the development of targeted drugsQ37659042
Inflammation and colon cancerQ37737408
TAM receptor signaling and autoimmune diseaseQ37804572
Targeting Axl and Mer kinases in cancerQ37936028
Regulation of NF-κB by deubiquitinasesQ37995682
Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel diseaseQ38450732
Differential expression of Axl and correlation with invasion and multidrug resistance in cancer cellsQ39366947
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.Q39381139
AXL regulates mesothelioma proliferation and invasivenessQ39623714
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapiesQ39684120
Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase InhibitorsQ40256784
Chemically induced mouse models of intestinal inflammationQ42510602
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancerQ43166849
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiformeQ46825520
Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activatQ46881381
Axl, a novel receptor tyrosine kinase isolated from chronic myelogenous leukemia.Q53022023
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectcolon cancerQ18555025
MER proto-oncogene tyrosine kinaseQ21987691
AXL receptor tyrosine kinaseQ21991362
P304page(s)13091–13096
P577publication date2013-08-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleParadoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer
P478volume110

Reverse relations

cites work (P2860)
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Q33591281Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma
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Q54297620Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?
Q35872028Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma
Q36287092Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma
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