Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma

scientific article published on 21 March 2014

Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1302766
P932PMC publication ID4509623
P698PubMed publication ID24659691
P5875ResearchGate publication ID261034799

P50authorCory M HogaboamQ61079289
P2093author name stringTakehiko Shibata
Nicholas W Lukacs
Steven L Kunkel
Ana L Coelho
David M Habiel
P2860cites workTIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserineQ21131381
The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entryQ24299966
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entryQ24620686
Tyro3 family-mediated cell entry of Ebola and Marburg virusesQ24670567
Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptorsQ37188519
Respiratory viral infections: knowledge based therapeutics.Q38024439
Benefit and harm from immunity to respiratory syncytial virus: implications for treatmentQ38053916
The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.Q38104686
Expression profiling of genes related to asthma exacerbationsQ38356926
ABL regulation by AXL promotes cisplatin resistance in esophageal cancerQ39250660
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiformeQ39370401
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.Q39381139
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapiesQ39684120
Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?Q39788660
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.Q40031486
A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibodyQ41838847
Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseasesQ44747069
Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretionQ45166227
Effects of repeated respiratory syncytial virus infections on pulmonary dendritic cells in a murine model of allergic asthmaQ45394041
Effects of respiratory syncytial virus infection on dendritic cells and cysteinyl leukotrienes in lung tissues of a murine model of asthmaQ45404697
Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13.Q45556830
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.Q46021434
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responsesQ47777274
Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndromeQ48001254
Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation.Q52014685
Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza InfectionQ57077389
Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsisQ61835531
Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutrophilsQ77584477
Viral apoptotic mimicry party: P.S. Bring your own Gas6Q83894683
Influenza: old and new threatsQ28296381
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancerQ28588141
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
Mortality associated with influenza and respiratory syncytial virus in the United StatesQ29615578
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Influenza-associated hospitalizations in the United StatesQ29619463
Are we ready for pandemic influenza?Q30233355
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.Q30438825
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.Q31929744
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune responseQ33595572
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survivalQ33667156
Immunobiology of the TAM receptorsQ33796991
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activityQ33960576
Importance of cytokines in murine allergic airway disease and human asthmaQ34003580
Altered eosinophil levels as a result of viral infection in asthma exacerbation in childhoodQ34127588
Risk of primary infection and reinfection with respiratory syncytial virusQ34188122
Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivityQ34232132
Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosusQ34979215
An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degenerationQ35221034
Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virusQ35222083
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout miceQ35307873
The wheezy infant -- immunological and molecular considerationsQ35674141
Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatusQ35745429
Modulation of macrophage efferocytosis in inflammationQ35927561
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerQ36128435
Mechanisms of respiratory syncytial virus modulation of airway immune responsesQ36203787
Cytokines and respiratory syncytial virus infectionQ36237044
Viral and host factors in human respiratory syncytial virus pathogenesisQ36483836
Growth arrest-specific gene 6 expression in human breast cancer.Q36510114
The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized miceQ36540047
Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthmaQ36904217
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectasthmaQ35869
P304page(s)3569-3581
P577publication date2014-03-21
P1433published inJournal of ImmunologyQ3521441
P1476titleAxl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma
P478volume192

Reverse relations

cites work (P2860)
Q40117278A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease
Q40062737Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function
Q34619118Axl as a mediator of cellular growth and survival
Q34390266Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities
Q39181829Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages
Q38927479Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza A viruses via upregulation of SOCS1 and SOCS3.
Q38539476New insights on the viral and host factors contributing to the airway pathogenesis caused by the respiratory syncytial virus.
Q26766332Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Q95856210Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders
Q97644477Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells
Q35819380TAM receptor signaling in immune homeostasis
Q38729745TAM receptor tyrosine kinase function and the immunopathology of liver disease
Q64056430Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
Q54116750Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis.
Q35602267The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.
Q37073027The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Q36359800The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
Q40432439Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation
Q38520018Viral apoptotic mimicry

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