AXL kinase as a novel target for cancer therapy

scientific article

AXL kinase as a novel target for cancer therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2542
P3181OpenCitations bibliographic resource ID2517960
P932PMC publication ID4259419
P698PubMed publication ID25337673
P5875ResearchGate publication ID279601568

P2093author name stringBalazs Halmos
Zhenfeng Zhang
Xiaoliang Wu
Xuewen Liu
Chang Youl Lee
Sanjay Koul
P2860cites workStructural basis for Gas6-Axl signalling.Q24299209
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathwayQ24307937
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-siteQ24309038
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transitionQ24310051
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseQ24310364
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascadeQ24310383
Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3Q24321841
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survivalQ24546291
MET inhibitors in combination with other therapies in non-small cell lung cancerQ26823203
Epithelial-mesenchymal transitions: insights from developmentQ26865944
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamilyQ27654013
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft modelsQ27675641
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.Q39381139
Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markersQ39434080
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growthQ39472261
Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugsQ39491304
Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase.Q39499581
Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cellsQ39512409
Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancerQ39587794
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancerQ39592978
AXL regulates mesothelioma proliferation and invasivenessQ39623714
Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members.Q39633320
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancerQ39634782
Differential expression of Axl in hepatocellular carcinoma and correlation with tumor lymphatic metastasisQ39679535
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapiesQ39684120
Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancerQ39741566
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.Q39813764
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesisQ39820482
The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylationQ39975842
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cellsQ39991840
AXL is a potential target for therapeutic intervention in breast cancer progression.Q40002526
Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathwayQ40190955
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.Q40289611
Multiple roles for the receptor tyrosine kinase axl in tumor formationQ40360957
Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancerQ40390404
An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous systemQ41183910
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell linesQ41235107
Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradationQ42155234
Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breastQ43695197
Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesionQ43777232
Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cellsQ43805305
Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluationQ44192096
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stromaQ44378605
Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survivalQ44732841
Coexpression of Gas6/Axl in human ovarian cancersQ45081570
Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival.Q45945576
Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemiaQ46576090
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiformeQ46825520
Cloning and developmental expression analysis of the murine c-mer tyrosine kinaseQ48072816
The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysisQ48168458
TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.Q53090999
TAM receptor function in the retinal pigment epitheliumQ56878898
First Axl inhibitor enters clinical trialsQ85717127
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.Q27852553
C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migrationQ28244101
Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and AxlQ28277798
The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesisQ28280019
Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesisQ28286679
Genes specifically expressed at growth arrest of mammalian cellsQ28297811
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodelingQ28513114
Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosisQ28513697
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ28585446
Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ28585555
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancerQ28588141
XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC.Q30428632
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.Q31929744
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.Q33357894
Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinomaQ33514834
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.Q33622570
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survivalQ33667156
Multifunctional aptamer-miRNA conjugates for targeted cancer therapy.Q33724277
Immunobiology of the TAM receptorsQ33796991
A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5bQ33918209
Galectin-3 is a new MerTK-specific eat-me signalQ33972695
TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous systemQ34077622
RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serumQ34097404
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinomaQ34515144
PTEN: The down side of PI 3-kinase signalling.Q34540849
TAZ expression as a prognostic indicator in colorectal cancerQ34571020
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.Q34576544
The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapyQ34667753
Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands.Q37955105
A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumorsQ38304282
Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancersQ38353801
MerTK inhibition is a novel therapeutic approach for glioblastoma multiformeQ39012846
Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinomaQ39063025
MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activationQ39069521
Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanismQ39092295
Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocationQ39102364
Inhibition of tumor growth and metastasis in non-small cell lung cancer by LY2801653, an inhibitor of several oncokinases, including MET.Q39103018
S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumabQ39134353
Secretome proteins as candidate biomarkers for aggressive thyroid carcinomas.Q39210485
YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl.Q39214406
ABL regulation by AXL promotes cisplatin resistance in esophageal cancerQ39250660
HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitorsQ39263953
The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinomaQ39355557
Expression of axl in lung adenocarcinoma and correlation with tumor progressionQ34768498
Phosphoproteomic analysis of Her2/neu signaling and inhibitionQ34772747
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancerQ34794927
Macrophage regulation by Tyro 3 family receptorsQ35031954
Mechanisms of acquired resistance to EGFR-tyrosine kinase inhibitor in Korean patients with lung cancer.Q35076221
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivationQ35390011
Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinomaQ35486521
Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cellsQ35677075
Personalizing therapy with targeted agents in non-small cell lung cancerQ35679361
Transforming activity of retroviral genomes encoding Gag-Axl fusion proteinsQ35872635
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.Q35899490
Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancerQ36044487
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNAQ36054278
Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognitionQ36110345
AXL is an essential factor and therapeutic target for metastatic ovarian cancerQ36127308
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerQ36128435
Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancerQ36413157
Targeting Axl with an high-affinity inhibitory aptamer.Q36460465
Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase AxlQ36481940
Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinasesQ36493822
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceQ36597042
The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesotheliomaQ36671963
Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic targetQ36682854
Axl-dependent signalling: a clinical updateQ36720080
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancerQ36822111
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic targetQ37182283
Biology of the TAM receptorsQ37258717
Higher expression of receptor tyrosine kinase Axl, and differential expression of its ligand, Gas6, predict poor survival in lung adenocarcinoma patientsQ37369038
AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.Q37451822
Imaging Axl expression in pancreatic and prostate cancer xenograftsQ37571724
Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotypeQ37589120
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cellsQ37627397
AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cellsQ37715171
Targeting Axl and Mer kinases in cancerQ37936028
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectreceptor tyrosine kinaseQ420511
neoplasmQ1216998
proto-oncogene proteinQ66020913
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)9546-63
P577publication date2014-10-30
P1433published inOncotargetQ1573155
P1476titleAXL kinase as a novel target for cancer therapy
P478volume5

Reverse relations

cites work (P2860)
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Q37189265ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling
Q92814606AXL Controls Directed Migration of Mesenchymal Triple-Negative Breast Cancer Cells
Q35843071AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas
Q36414168AXL is an oncotarget in human colorectal cancer.
Q37684598AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer
Q42359111AXL-GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
Q91906063Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations
Q40420136Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer
Q92062648Axl and autophagy LC3 expression in tumors is strongly associated with clinical prognosis of hepatocellular carcinoma patients after curative resection
Q49737040Axl inhibition induces the antitumor immune response which can be further potentiated by PD-1 blockade in the mouse cancer models
Q58804596Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition
Q64097927Axl signaling is an important mediator of tumor angiogenesis
Q39095878Biomarkers for EMT and MET in breast cancer: An update
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