PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility

scientific article

PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..11118643X
P356DOI10.1073/PNAS.1413186112
P3181OpenCitations bibliographic resource ID3825969
P932PMC publication ID4284526
P698PubMed publication ID25512490
P5875ResearchGate publication ID269709516

P2093author name stringBingfang Xu
Angela M Washington
Barry T Hinton
P2860cites workThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
PTEN regulation of ERK1/2 signaling in cancerQ27011088
Phosphorylation and regulation of Raf by Akt (protein kinase B)Q28138863
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymisQ28589934
The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymisQ28594119
Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermiaQ28594963
Testicular lumicrine factors regulate ERK, STAT, and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosisQ30426591
p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in miceQ30429887
Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymisQ30439130
How do you get six meters of epididymis inside a human scrotum?Q30453138
Transepithelial projections from basal cells are luminal sensors in pseudostratified epitheliaQ30486105
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenQ30524175
Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulationQ31086055
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formationQ33795723
ROS1 signaling regulates epithelial differentiation in the epididymisQ34068363
PTEN function in mammalian cell size regulationQ34942330
Mouse models of infertility due to swollen spermatozoaQ35756577
Differential positioning of adherens junctions is associated with initiation of epithelial foldingQ36683787
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue surveyQ37270420
The rat epididymal transcriptome: comparison of segmental gene expression in the rat and mouse epididymidesQ40260520
Epididymal dysfunction initiated by the expression of simian virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic miceQ44196817
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific mannerQ46952728
Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.Q50474946
Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanismsQ52976964
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomasQ60021742
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectPhosphatase and tensin homologQ14878408
Tight junction protein 1Q21496047
Cadherin 2Q21981240
Ets variant 4Q21984455
P304page(s)18643-18648
P577publication date2014-12-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility
P478volume111

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cites work (P2860)
Q56380577Alteration of transporter activities in the epididymides of infertile initial segment-specific Pten knockout mice
Q92575796Comparative Transcriptomic Analysis Reveals Molecular Profiles of Central Nervous System in Maternal Diapause Induction of Locusta migratoria
Q40999374Functional Role and Mechanism of microRNA-28b in Atrial Myocyte in a Persistent Atrial Fibrillation Rat Model.
Q93217157Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway
Q30276611Initial Segment Differentiation Begins During a Critical Window and Is Dependent upon Lumicrine Factors and SRC Proto-Oncogene (SRC) in the Mouse
Q30276902Is the Epididymis a Series of Organs Placed Side By Side?
Q46607490Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis
Q37057433Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice
Q39180467Molecular changes and signaling events occurring in spermatozoa during epididymal maturation.
Q90999747NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis
Q36395967PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland
Q30277207Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct
Q28081095Regulation of epithelial function, differentiation, and remodeling in the epididymis
Q132042932Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?
Q50086948Seasonal variation of cell proliferation and apoptosis in the efferent ductules and epididymis of the Neotropical bat Artibeus lituratus (Chiroptera, Phyllostomidae).
Q38549842Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function
Q36239755Small RNA sequencing of cryopreserved semen from single bull revealed altered miRNAs and piRNAs expression between High- and Low-motile sperm populations
Q30279109Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice

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