A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

scientific journal article

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20132267
P932PMC publication ID4042651
P698PubMed publication ID24863065
P5875ResearchGate publication ID262646182

P50authorSeth Thomas ScanlonQ55965825
Jeffrey J BunkerQ83659284
Michael G ConstantinidesQ39032555
P2093author name stringJeffrey D Singer
Albert Bendelac
Alexander L Dent
Aaron R Dinner
Benjamin D McDonald
Rebecca Mathew
Kristin Hollister
Andrew H Chiang
Clara Bertozzi-Villa
Ai-ping Mao
P2860cites workCullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsQ22010574
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligaseQ24336527
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)Q24599046
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
The AP-1 transcription factor Batf controls T(H)17 differentiationQ24644525
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimerQ24685712
Requirement for RORgamma in thymocyte survival and lymphoid organ developmentQ28139666
Bcl6 mediates the development of T follicular helper cellsQ28252825
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiationQ28504952
SAP controls T cell responses to virus and terminal differentiation of TH2 cells.Q43692363
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.Q43967840
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitmentQ50736370
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphomaQ52548831
BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymusQ73335996
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrowQ77531813
Batf coordinates multiple aspects of B and T cell function required for normal antibody responsesQ28505147
Constitutive turnover of cyclin E by Cul3 maintains quiescenceQ28506695
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunityQ28507088
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexesQ28508859
Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repressionQ28512151
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationQ28584806
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
Compensatory dendritic cell development mediated by BATF-IRF interactionsQ28586184
A validated regulatory network for Th17 cell specificationQ28586624
BATF–JUN is critical for IRF4-mediated transcription in T cellsQ28590152
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cellsQ28593666
Inhibition of Th2 differentiation and GATA-3 expression by BCL-6Q28594529
Follicular helper CD4 T cells (TFH)Q29615063
Illustration of SSMD, z Score, SSMD*, z* Score, and t Statistic for Hit Selection in RNAi High-Throughput ScreensQ34180188
Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammationQ34339027
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomasQ34380954
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanismsQ34633877
Structural regulation of cullin-RING ubiquitin ligase complexesQ35151712
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.Q35525803
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cellsQ35607142
Early Th1 cell differentiation is marked by a Tfh cell-like transitionQ35630458
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.Q36206343
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanismsQ36703936
Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Q37155667
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor bindingQ37266009
Germinal center B and follicular helper T cells: siblings, cousins or just good friends?Q37899118
How T Cells Earn the Follicular Rite of PassageQ37961194
Roles of BCL6 in normal and transformed germinal center B cellsQ38002492
Transcriptional regulation of follicular T‐helper (Tfh) cellsQ38081173
BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.Q39255572
Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response.Q41193370
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosisQ42050945
Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse modelQ42073063
ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6Q42136332
Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophagesQ42468395
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
T follicular helper cellQ5464650
B cell leukemia/lymphoma 6Q21428928
Cullin 3Q21981309
P304page(s)1137-1151
P577publication date2014-06-02
P1433published inJournal of Experimental MedicineQ3186912
P1476titleA negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation
P478volume211

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cites work (P2860)
Q35686130Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function
Q36073362Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Q58556221Molecular Control of Follicular Helper T cell Development and Differentiation
Q41978406Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.
Q88446289Posttranscriptional regulation of T helper cell fate decisions
Q28072283Regulators of Tfh Cell Differentiation
Q97905775The transcription factor BCL-6 controls early development of innate-like T cells
Q38835389Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function
Q26770849Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling

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