Early Th1 cell differentiation is marked by a Tfh cell-like transition

scientific article published on December 2011

Early Th1 cell differentiation is marked by a Tfh cell-like transition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2011.11.012
P932PMC publication ID3244883
P698PubMed publication ID22195747
P5875ResearchGate publication ID51921833

P50authorGordon L. HagerQ67401984
Ofir HakimQ89232316
P2093author name stringDragana Jankovic
John J O'Shea
Yuka Kanno
Golnaz Vahedi
Hayato Takahashi
Pamela L Schwartzberg
Robin Handon
Thomas A Johnson
Shingo Nakayamada
Kristina T Lu
Hong-wei Sun
P2860cites workInterleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's diseaseQ24298010
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expressionQ24556668
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsQ24595285
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent mannerQ24644925
Follicular helper T cells: lineage and locationQ24647274
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cellsQ24655629
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
Bcl6 mediates the development of T follicular helper cellsQ28252825
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesQ28295404
The lineage decisions of helper T cellsQ29614841
Follicular helper CD4 T cells (TFH)Q29615063
Functional diversity of helper T lymphocytesQ29619415
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) DifferentiationQ33851778
In vivo regulation of Bcl6 and T follicular helper cell developmentQ33936471
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cellsQ33952975
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiationQ33997593
Effector T cell plasticity: flexibility in the face of changing circumstancesQ34126977
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cellsQ34383385
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretionQ34615273
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cellsQ34973705
Molecular mechanisms regulating Th1 immune responsesQ35034059
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.Q35141261
An epigenetic view of helper T cell differentiationQ35164202
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cellsQ35607142
The molecular basis of IL-21-mediated proliferationQ35828741
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
T follicular helper (TFH) cells in normal and dysregulated immune responsesQ37049341
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosusQ37070948
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacitiesQ37129666
Epigenetic control of T-helper-cell differentiationQ37371624
Epigenetics and T helper 1 differentiationQ37380019
Understanding the development and function of T follicular helper cells.Q37728834
The elusive identity of T follicular helper cellsQ37784588
Identification of genes involved in the initiation of human Th1 or Th2 cell commitmentQ38320010
Development and characterization of IL-21-producing CD4+ T cellsQ38845667
Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.Q42133564
ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6Q42136332
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expressionQ43828654
Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritisQ47911361
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.Q50731194
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitmentQ50736370
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patchesQ51769095
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cellsQ74082060
Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseasesQ83052329
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
T follicular helper cellQ5464650
P304page(s)919-931
P577publication date2011-12-01
P1433published inImmunityQ6005457
P1476titleEarly Th1 cell differentiation is marked by a Tfh cell-like transition
P478volume35

Reverse relations

cites work (P2860)
Q50882786A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium
Q28593152A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation
Q52975959A pathogenetic role for IL-21 in primary Sjögren syndrome
Q33736430A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes
Q26866169Activation of B cells by non-canonical helper signals
Q54316357Activation of Syk in peripheral blood B cells in patients with rheumatoid arthritis: a potential target for abatacept therapy
Q58778777Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody
Q36067435Activin A programs the differentiation of human TFH cells
Q37745334Amino-acid transporters in T-cell activation and differentiation
Q35031602An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
Q40722308An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells
Q39000453An Update on Lymphocyte Subtypes in Asthma and Airway Disease
Q30833502An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons
Q89295096Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes
Q39543728Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells
Q61449528B-Cell Lymphoma 6 (BCL6) Is a Host Restriction Factor That Can Suppress HBV Gene Expression and Modulate Immune Responses
Q47095865BAFF- and APRIL-targeted therapy in systemic autoimmune diseases
Q34033637BCL6 controls Th9 cell development by repressing Il9 transcription
Q38959240Bcl-6 directly represses the gene program of the glycolysis pathway
Q39852423Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
Q33592713Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation
Q41607377Bob1 limits cellular frequency of T-follicular helper cells
Q37651727CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?
Q38535279CD4 T cell differentiation in type 1 diabetes.
Q35073840CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection
Q24628780CXCR5⁺ T helper cells mediate protective immunity against tuberculosis
Q64094870Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy
Q50604412Chromatin priming elements establish immunological memory in T cells without activating transcription: T cell memory is maintained by DNA elements which stably prime inducible genes without activating steady state transcription.
Q53618640Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production
Q34240220Complex interactions of transcription factors in mediating cytokine biology in T cells
Q34391413Computational modeling of heterogeneity and function of CD4+ T cells
Q34678313Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms
Q92617580Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
Q38159861Control of TFH cell numbers: why and how?
Q27026513Control of adaptive immunity by the innate immune system
Q97554699Conventional type 1 dendritic cells induce TH 1, TH 1-like follicular helper T cells and regulatory T cells after antigen boost via DEC205 receptor
Q34059261Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity
Q39852374Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation
Q38303479Cytokine crowdsourcing: multicellular production of TH17-associated cytokines
Q35161754Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFNγ- Thpp cells
Q34518223Dendritic cells and B cells: unexpected partners in Th2 development
Q50589517Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis
Q35207997Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria
Q40241860Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells
Q39384272Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets.
Q39099558Dynamic changes in chromatin conformation at the TNF transcription start site in T helper lymphocyte subsets
Q38108059Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells
Q92127108Dysregulation of T Follicular Helper Cells in Lupus
Q26778348Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues
Q38221815Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Q90348321Effects of a blend of Saccharomyces cerevisiae-based direct-fed microbial and fermentation products in the diet of newly weaned beef steers: growth performance, whole-blood immune gene expression, serum biochemistry, and plasma metabolome1
Q40208549Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation
Q38805222Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines
Q89065038Exploiting vita-PAMPs in vaccines
Q37248864Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
Q55500635Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective.
Q38154470Follicular T-helper cells: controlled localization and cellular interactions
Q35242659Follicular helper T cell signature in type 1 diabetes
Q35970620Functional STAT3 deficiency compromises the generation of human T follicular helper cells.
Q42318115Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis .
Q30580583Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data
Q61797820Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation
Q56950294Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development
Q34255017Helper T cell diversity and plasticity
Q34356521Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes
Q36623362Helper T-cell identity and evolution of differential transcriptomes and epigenomes.
Q35913550Human IL-21+IFN-γ+CD4+ T cells in nasal polyps are regulated by IL-12.
Q35568440ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis
Q35863341IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
Q36780627IL-12 induced the generation of IL-21- and IFN-γ-co-expressing poly-functional CD4+ T cells from human naive CD4+ T cells
Q36797259IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans
Q90390275IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population
Q35814940IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4(+)CXCR5(+) TFH Cells
Q36511197IL-7 signalling represses Bcl-6 and the TFH gene program.
Q37026383Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.
Q95645335Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception
Q37625985Identification of novel markers for mouse CD4(+) T follicular helper cells
Q45737293Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity
Q58777530Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology
Q38875184Insights into the development and regulation of T follicular helper cells.
Q37617212Insights into the role of follicular helper T cells in autoimmunity
Q38605092Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells.
Q88562718Interleukin-6: designing specific therapeutics for a complex cytokine
Q36404704JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
Q30717456Large-scale quality analysis of published ChIP-seq data
Q26825249Life of T follicular helper cells
Q34305590Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors
Q27687830Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease
Q39115619Melatonin signaling in T cells: Functions and applications
Q26829047Memory T follicular helper CD4 T cells
Q36305539MicroRNA-155-IFN-γ Feedback Loop in CD4(+)T Cells of Erosive type Oral Lichen Planus
Q60046093MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes
Q37693699MicroRNA-mediated regulation of T helper cell differentiation and plasticity.
Q58556221Molecular Control of Follicular Helper T cell Development and Differentiation
Q34336633Molecular control of Tfh-cell differentiation by Roquin family proteins.
Q38370894Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory.
Q54261860MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage
Q28384506Mycobacterium tuberculosis-Specific IL-21+IFN-γ+CD4+ T Cells Are Regulated by IL-12
Q92921962Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses
Q56363429Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
Q38110970New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes
Q26801199New insights into T cells and their signature cytokines in atopic dermatitis
Q37635735Of mice and men: how animal models advance our understanding of T-cell function in RA.
Q55312721Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.
Q35695090Pathophysiology of T follicular helper cells in humans and mice
Q36220467Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells
Q37137467Phenotypic and functional characteristics of IL-21-expressing CD8(+) T cells in human nasal polyps
Q36903805Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses
Q90650342Potential Pathways Associated With Exaggerated T Follicular Helper Response in Human Autoimmune Diseases
Q38154469Priming of T follicular helper cells by dendritic cells
Q46206655Progression of autoimmune hepatitis is mediated by IL-18-producing dendritic cells and hepatic CXCL9 expression in mice
Q36543544Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells
Q26830939Regulation of human helper T cell subset differentiation by cytokines
Q28066034Regulation of immunity during visceral Leishmania infection
Q28072283Regulators of Tfh Cell Differentiation
Q34416635Regulatory T cells in B cell follicles
Q38147883Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility
Q38306720Relevance of lymphocyte subsets to B cell-targeted therapy in systemic lupus erythematosus
Q58580426Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses
Q35043957Runx3-mediated transcriptional program in cytotoxic lymphocytes.
Q47355847STAT4 and T-bet control follicular helper T cell development in viral infections.
Q42372583STAT4 gene polymorphism in patients after renal allograft transplantation
Q90744992STAT4: an immunoregulator contributing to diverse human diseases
Q36431152STATs shape the active enhancer landscape of T cell populations
Q37155667Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.
Q34501482Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.
Q34970100Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.
Q36009259Stat3 Is Important for Follicular Regulatory T Cell Differentiation
Q34463140Super-enhancers delineate disease-associated regulatory nodes in T cells
Q41847407Sustained interactions between T cell receptors and antigens promote the differentiation of CD4⁺ memory T cells.
Q39186442T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation.
Q58712847T Cells That Help B Cells in Chronically Inflamed Tissues
Q55104293T Follicular Helper-Like Cells Are Involved in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Q42002627T Helper Cell Differentiation, Heterogeneity, and Plasticity.
Q54216771T cell-derived Lymphotoxin is Essential for anti-HSV-1 Humoral Immune Response
Q60045987T cell-derived lymphotoxin limits Th1 response during HSV-1 infection
Q28395374T cell-mediated host immune defenses in the lung
Q83316449T cells: The TFH-like transition of TH1 cells
Q38264816T follicular helper cell differentiation, function, and roles in disease
Q36823844T follicular helper cell diversity and plasticity
Q92382973T follicular helper cell heterogeneity: Time, space, and function
Q38904415T follicular helper cell programming by cytokine-mediated events.
Q91755050T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Q38940412T follicular helper cells in space-time.
Q49702451T follicular helper cells: a potential therapeutic target in follicular lymphoma
Q35940715T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
Q39689800T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex
Q50102251T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1.
Q38685822T-bet as a key regulator of mucosal immunity.
Q36919883T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine
Q47785882T-bet over-expression regulates aryl hydrocarbon receptor-mediated T helper type 17 differentiation through an interferon (IFN)γ-independent pathway
Q35279922T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
Q38151473T-bet: a bridge between innate and adaptive immunity.
Q34327596T-cell subsets in the germinal center.
Q38279985TCR signal quantity and quality in CD4(+) T cell differentiation.
Q35105613Tailored immune responses: novel effector helper T cell subsets in protective immunity
Q55030447Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes.
Q38803247Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease
Q47315531Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity
Q88473114Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity
Q36443069The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.
Q98465723The Impact of Malaria Parasites on Dendritic Cell-T Cell Interaction
Q90601924The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells
Q64102236The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection
Q86415886The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3
Q34280534The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
Q38388255The importance of co-stimulation in the orchestration of T helper cell differentiation
Q37038839The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Q36118326The origins, function, and regulation of T follicular helper cells
Q34450488The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization
Q38217859The role of protein modifications of T-bet in cytokine production and differentiation of T helper cells.
Q24563655The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
Q41088363The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
Q35111225The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa
Q38121496The unique features of follicular T cell subsets
Q89457667Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6
Q38213100Therapeutic potential of STAT4 in autoimmunity
Q48232264Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells.
Q37643938Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation
Q37711709Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells
Q34873216Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation
Q34490684Transcription factor co-occupied regions in the murine genome constitute T-helper-cell subtype-specific enhancers.
Q38123463Transcription factor interplay in T helper cell differentiation
Q100395393Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment
Q35064355Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Q39163678Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity
Q34979730Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.
Q37666675Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program
Q38835389Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function
Q34091987Unbalanced Neonatal CD4(+) T-Cell Immunity
Q28067648Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together
Q37178987Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
Q26849423Using epigenetics to define vaccine-induced memory T cells
Q40474391Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway.
Q92913428ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
Q40537683mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
Q39865491miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

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