Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

scientific article

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20062175
P932PMC publication ID2118735
P698PubMed publication ID17283209
P5875ResearchGate publication ID6521944

P50authorRichard FlavellQ2149481
Carl G FengQ58415474
Alan SherQ88390533
P2093author name stringMark Wilson
Dragana Jankovic
Masahito Kamanaka
Marika C Kullberg
Thomas A Wynn
Romina S Goldszmid
Carmen M Collazo
P2860cites workImmunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouseQ28589701
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluidsQ29616817
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis PatientsQ61885691
High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61Q69972984
Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clonesQ70054755
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 moleculeQ70452024
Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine productionQ70527759
Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of toleranceQ72230111
Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cellsQ72233222
Effect of interleukin-10 on dendritic cell maturation and functionQ73396250
Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In VivoQ73407790
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profileQ73520544
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondiiQ73755946
Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondiiQ73948679
Increased resistance to mycobacterial infection in the absence of interleukin-10Q74121921
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cellsQ75303125
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemQ80102518
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Functional diversity of helper T lymphocytesQ29619415
IL-10 inhibits cytokine production by activated macrophagesQ29619453
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondiiQ33762617
Regulatory activity of autocrine IL-10 on dendritic cell functionsQ33938563
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivationQ33996487
Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient miceQ34004385
Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice.Q34262167
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophagesQ34732969
Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondiiQ35495758
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigensQ36228356
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasisQ36229713
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigensQ36355614
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.Q36370082
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.Q36370315
Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infectionQ36371418
Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitisQ36376571
Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosisQ36376986
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondiiQ36377044
Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cellsQ37137636
Increased antimycobacterial immunity in interleukin-10-deficient miceQ39510966
Reprogramming of IL-10 activity and signaling by IFN-gamma.Q40618355
Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assayQ42810576
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signalQ42834238
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritationQ42971196
IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivoQ42971329
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingQ45069275
Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.Q45306726
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cellsQ45878833
Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivityQ46061458
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionQ47388000
Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice.Q51720480
CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages.Q51720779
Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection.Q52522603
The role of IL-12 in maintaining resistance to Leishmania major.Q53669928
Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.Q53863572
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Q54195040
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivoQ57339964
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)273-283
P577publication date2007-02-05
P1433published inJournal of Experimental MedicineQ3186912
P1476titleConventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
P478volume204

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cites work (P2860)
Q97521515A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection
Q92132535A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation
Q60321325A TGF-β mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children
Q35621970A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease
Q30479825A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria
Q42933354A toxin-sensitive receptor able to reduce immunopathology
Q37365728Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice
Q93246874Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs
Q60920705Activation of Human CD11b B1 B-Cells by -Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease
Q28740775Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age
Q28109688Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function
Q41990100Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice
Q37275304Adoptive immunotherapy of cancer using CD4(+) T cells
Q39980910Advances in understanding immunity to Toxoplasma gondii
Q26828969Allergens are not pathogens: why immunization against allergy differs from vaccination against infectious diseases
Q58107160Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties
Q37618059Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.
Q24642507Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
Q35964276Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis
Q30433210Antibody and cytokine responses to house dust mite allergens and Toxoplasma gondii antigens in atopic and non-atopic Brazilian subjects
Q42448098Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells.
Q36537972Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice
Q64938549Ascites IL-10 Promotes Ovarian Cancer Cell Migration.
Q37386065BAC talk about cell type-specific regulation of human IL-10.
Q36514124Balance between NF-κB p100 and p52 regulates T cell costimulation dependence
Q33730117Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent
Q35893711Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.
Q40082278Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice
Q35143581Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii
Q39291870Brains and Brawn: Toxoplasma Infections of the Central Nervous System and Skeletal Muscle
Q33730136CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
Q34813153CD4 T cells: fates, functions, and faults
Q36229713CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
Q37333485CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis
Q43605525CD4+ Foxp3+ regulatory T cells mediate Toxoplasma gondii-induced T-cell suppression through an IL-2-related mechanism but independently of IL-10.
Q30430530CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
Q37194971CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
Q36555745CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells
Q37689388CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection
Q37678256Cell type-specific regulation of IL-10 expression in inflammation and disease
Q35920721Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa
Q33944309Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1
Q37462813Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity
Q39299547Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells
Q37277416Comparative Analysis of Conventional Natural Killer Cell Responses to Acute Infection with Toxoplasma gondii Strains of Different Virulence
Q33570304Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
Q26779956Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis
Q42320886Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential.
Q27009419Contextual functions of antigen-presenting cells in the gastrointestinal tract
Q37106740Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
Q43494254Control of Schistosoma mansoni egg‐induced inflammation by IL‐4‐responsive CD4+CD25−CD103+Foxp3− cells is IL‐10‐dependent
Q35021925Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade
Q34374026Current status of interleukin-10 and regulatory T-cells in cancer
Q45858121Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10(+)IFN-gamma(+)CD4(+) T cells
Q27007128Cytokine reporter mice: the special case of IL-10
Q37863274Cytokines and effector T cell subsets causing autoimmune CNS disease
Q35294461Cytokines in autoimmune uveitis
Q35294424Cytokines in autoimmunity: role in induction, regulation, and treatment
Q36229323Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
Q36214992Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence
Q33624096Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
Q37622515Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus
Q45589897Dendritic cells devoid of IL-10 induce protective immunity against the protozoan parasite Trypanosoma cruzi
Q48616399Depletion of CD25⁺ cells during acute toxoplasmosis does not significantly increase mortality in Swiss OF1 mice
Q37594367Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells.
Q92539043Dietary Fiber Pectin Ameliorates Experimental Colitis in a Neutral Sugar Side Chain-Dependent Manner
Q64954303Disease Tolerance in Toxoplasma Infection.
Q33426367Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
Q37374961Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation.
Q47166039Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes
Q35630458Early Th1 cell differentiation is marked by a Tfh cell-like transition
Q35965247Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations
Q30438825Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.
Q41519470Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease.
Q36313607Enhancement of the sensitivity of the whole-blood gamma interferon assay for diagnosis of Mycobacterium bovis infections in cattle.
Q36713490Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite
Q93090571Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells
Q38107626Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation
Q90407626Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus
Q38689861Examining cellular immune responses to inform development of a blood-stage malaria vaccine.
Q35152209Exposure-dependent control of malaria-induced inflammation in children
Q36594030Functional analysis of effector and regulatory T cells in a parasitic nematode infection
Q37374974Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii
Q37601515Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell-dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells.
Q40735854HIV-infected CD4+ T Cells Use T-bet-dependent Pathway for Production of IL-10 Upon Antigen Recognition
Q81473187Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production
Q33923702Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner
Q36388771Heterogeneity and plasticity of T helper cells
Q37578374Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
Q36989093Highlights of 10 years of immunology in Nature Reviews Immunology
Q37596517How do regulatory T cells work?
Q29614262How regulatory T cells work
Q38040742Human Th17 subsets
Q35571367IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells
Q35863341IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
Q37458864IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children
Q27489722IL-10 Signaling Blockade Controls Murine West Nile Virus Infection
Q37297787IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge
Q33327498IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection
Q35659197IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
Q79914769IL-10 or not IL-10: that is the question
Q33927028IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
Q33979932IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
Q40746828IL-10 restricts memory T cell inflation during cytomegalovirus infection
Q36997267IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia
Q34387183IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis
Q38101674IL-10-producing lymphocytes in inflammatory disease
Q39186731IL-10: A Multifunctional Cytokine in Viral Infections.
Q37373090IL-21 mediates suppressive effects via its induction of IL-10.
Q61815267IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4IL-10IFN-γ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease
Q87811794IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1
Q36082334IL-27 and TGFβ mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis
Q35737807IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
Q34501413IL-27 promotes T cell-dependent colitis through multiple mechanisms
Q40044539IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.
Q35058854IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii
Q42572213Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood
Q37139722Identifying immune mechanisms mediating the hypertension during preeclampsia
Q37424237Ikaros is a regulator of Il10 expression in CD4+ T cells
Q34093793Immune evasive mechanisms contributing to persistent Leishmania donovani infection
Q24612341Immune response and immunopathology during toxoplasmosis
Q38256670Immune surveillance of the central nervous system in multiple sclerosis--relevance for therapy and experimental models.
Q26777195Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets
Q36678092Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model.
Q38342966Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites
Q39980904Immunopathology in ocular toxoplasmosis: facts and clues
Q36224997Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions
Q35097790Impairment of T cell function in parasitic infections
Q33557968Improved survival of mice deficient in secretory immunoglobulin M following systemic infection with Cryptococcus neoformans
Q35037044In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology
Q33565253In situ detection of Chlamydia pneumoniae, C. trachomatis, and cytokines among cardiovascular diseased patients from the Amazon region of Brazil
Q42289087In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells
Q41722504Increased FOXP3 expression in tumour-associated tissues of horses affected with equine sarcoid disease.
Q37290615Increased frequency of intestinal CD4+ T cells reactive with mycobacteria in patients with Crohn's disease
Q50517496Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.
Q41857121Infection and treatment immunizations for successful parasite vaccines
Q37127389Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.
Q51357523Inhibitory effect of prolactin on Toxoplasma proliferation in peripheral blood mononuclear cells from patients with hyperprolactinemia.
Q91890897Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection
Q37953824Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger
Q27011746Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain
Q35139231Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens
Q34995059Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Q41916760Interleukin-10 production by effector T cells: Th1 cells show self control
Q24653771Interleukin-10: new perspectives on an old cytokine
Q56930023Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Q30402980Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice
Q80678435Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-beta2-treated antigen-presenting cells
Q36103122Isolation and characterization of human interleukin-10-secreting T cells from peripheral blood
Q44903032Isoniazid treatment of Mycobacterium bovis in cattle as a model for human tuberculosis
Q33732619LPS-induced systemic inflammation is more severe in P2Y12 null mice
Q41772104Lck regulates IL‐10 expression in memory‐like Th1 cells
Q38873769Leishmania donovani influenced cytokines and Toll-like receptors expression among Sudanese visceral leishmaniasis patients
Q52867586Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway.
Q36500928Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants
Q33821137Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease
Q37118101Mechanisms and consequences of persistence of intracellular pathogens: leishmaniasis as an example.
Q42673182Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo
Q33853629Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease.
Q42854644Modulation of systemic antigen-specific immune responses by oral antigen in humans.
Q92242533Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease
Q33728334More stories on Th17 cells
Q35831296Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection
Q50531820Nanoparticle-Fusion Protein Complexes Protect against Mycobacterium tuberculosis Infection.
Q42024502Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.
Q37067780Negative regulation of Th17 responses
Q37133882New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
Q27320168Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production
Q36491342Notch regulates IL-10 production by T helper 1 cells
Q33564441Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate
Q40956254Parasite-Specific CD4+ IFN-γ+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection
Q36553535Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
Q34339707Partial regulatory T cell depletion prior to schistosomiasis vaccination does not enhance the protection
Q50959906Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Q36389513Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response
Q41716501Phenotype alterations in regulatory T-cell subsets in primary HIV infection and identification of Tr1-like cells as the main interleukin 10-producing CD4+ T cells
Q38310232Plasticity of human CD4 T cell subsets
Q44604244Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.
Q42074930Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.
Q48523077Preeclampsia: From Inflammation to Immunoregulation
Q34669530Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.
Q27005837Protection and pathology during parasite infection: IL-10 strikes the balance
Q34045043Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta
Q36481763Protective immune mechanisms in helminth infection
Q83194142Re-establishing immunological self-tolerance in autoimmune disease
Q38979322Regulation of Interleukin-10 Expression
Q28066034Regulation of immunity during visceral Leishmania infection
Q30409386Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?
Q40432363Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Q36975739Regulatory T cells and infection: a dangerous necessity
Q28578953Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host
Q34364993Regulatory T cells enhance susceptibility to experimental Trypanosoma congolense infection independent of mouse genetic background
Q80785928Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
Q36863866Regulatory T cells in health and disease
Q37961175Regulatory T cells in infection
Q34574231Regulatory T cells in many flavors control asthma
Q90685361Regulatory T cells in paracoccidioidomycosis
Q34251387Regulatory T cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by Leishmania (Viannia) species
Q28480551Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis
Q37365765Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum
Q92824342Regulatory roles of IL-10-producing human follicular T cells
Q36667250Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis
Q33583791Resistance to lipopolysaccharide-induced preterm delivery mediated by regulatory T cell function in mice
Q35207335Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
Q40511039Reverse plasticity: TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut.
Q64102179Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Infection
Q41844995Role of Blimp-1 in programing Th effector cells into IL-10 producers
Q35947458Role of CD4+ Foxp3+ Regulatory T Cells in Protection Induced by a Live Attenuated, Replicating Type I Vaccine Strain of Toxoplasma gondii
Q38266459Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections
Q36978927Role of T cells and dendritic cells in glomerular immunopathology.
Q36162862Role of endogenous and induced regulatory T cells during infections
Q34262223Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease
Q27021181Role of interleukin-10 in malaria: focusing on coinfection with lethal and nonlethal murine malaria parasites
Q41997469Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica
Q33633305Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.
Q37108927Specific gut commensal flora locally alters T cell tuning to endogenous ligands
Q36253846Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression
Q36229304Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis
Q37210723Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells
Q34314006Subversion of host cellular functions by the apicomplexan parasites
Q81578755Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
Q37332780Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury
Q37484974Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells
Q35084474Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis
Q35148851Systemic impact of intestinal helminth infections
Q37500301Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes
Q33995331Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection
Q34793513T Cell Activation and Proinflammatory Cytokine Production in Clinically Cured Tuberculosis Are Time-Dependent and Accompanied by Upregulation of IL-10.
Q38742184T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
Q37607104T cell cross-talk with kidney dendritic cells in glomerulonephritis
Q39110320T cell responses in the central nervous system
Q34795494T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine
Q92802893T cell-mediated immunity to malaria
Q37669790T helper 17 cells: discovery, function, and physiological trigger
Q36831662T(H)1 cells control themselves by producing interleukin-10.
Q37735267T-cell responses induced by allergen-specific immunotherapy
Q34137475T-cell responses to the DBLα-tag, a short semi-conserved region of the Plasmodium falciparum membrane erythrocyte protein 1.
Q57339893T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection
Q90021054T-cells producing multiple combinations of IFNγ, TNF and IL10 are associated with mild forms of dengue infection
Q36229095TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production
Q34712326TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
Q36340416TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE
Q39226435TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells
Q80695477TNF controls the infiltration of dendritic cells into the site of Leishmania major infection
Q36749486TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis
Q55287141TNF-α blockade impairs in vitro tuberculous granuloma formation and down modulate Th1, Th17 and Treg cytokines.
Q35679596Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells
Q35820734Th17 cells in human disease.
Q34215404The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria
Q33732215The CD8 T-cell road to immunotherapy of toxoplasmosis
Q42935116The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission
Q37761493The Family of IL-10-secreting CD4+ T cells
Q35641191The Group 3 Innate Lymphoid Cell Defect in Aryl Hydrocarbon Receptor Deficient Mice Is Associated with T Cell Hyperactivation during Intestinal Infection
Q39027956The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria.
Q26865518The Regulation of CD4(+) T Cell Responses during Protozoan Infections
Q59136452The Role of BACH2 in T Cells in Experimental Malaria Caused by AS
Q64252919The Role of IL-10 in Malaria: A Double Edged Sword
Q34331809The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden.
Q40156671The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells.
Q58417804The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10
Q37640488The aryl hydrocarbon receptor promotes IL-10 production by NK cells
Q61806376The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
Q36336588The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
Q37376021The different faces of Notch in T-helper-cell differentiation
Q26863747The gut mucosal immune response to Toxoplasma gondii
Q92937037The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming
Q28730911The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production
Q52923839The pro- and anti-inflammatory potential of IL-12: the dual role of Th1 cells.
Q31129671The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen
Q29615479The regulation of IL-10 production by immune cells
Q37859621The role of IL-10 in immune regulation during M. tuberculosis infection
Q33834419The role of inflammation in the pathology of preeclampsia
Q33689420The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control
Q88721030The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination
Q24298841The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
Q41762357The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
Q37029283The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
Q43434397Time dependent expression of cytokines in Mycobacterium bovis infected cattle lymph nodes.
Q51018682Tissue-based class control: the other side of tolerance.
Q37418141Toll-like receptor initiated host defense against Toxoplasma gondii
Q101166145Toxoplasma gondii and multiple sclerosis: a population-based case-control study
Q82720481Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice
Q33861565Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.
Q35064355Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Q93115962Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases
Q38042618Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells
Q37789145Transcriptional regulation of the mucosal immune system mediated by T-bet.
Q40687093Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling
Q36151935Tuning microenvironments: induction of regulatory T cells by dendritic cells
Q28554673Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria
Q37371463Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
Q37056347Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection
Q33523808Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection.
Q92126524miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity

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