Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis

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Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2015/639107
P932PMC publication ID4606092
P698PubMed publication ID26495323
P5875ResearchGate publication ID282430250

P50authorJuliana Reis MachadoQ89266881
P2093author name stringVirmondes Rodrigues
Carlo Jose Freire Oliveira
Marcos Vinicius da Silva
Denise Bertulucci Rocha Rodrigues
Monique Gomes Salles Tiburcio
Djalma Alexandre Alves Silva
P2860cites workRecruitment of Mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis.Q39299211
Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lungQ39319543
ESAT-6- and CFP-10-specific Th1, Th22 and Th17 cells in tuberculous pleurisy may contribute to the local immune response against Mycobacterium tuberculosis infectionQ39373309
The effect of interleukin-10 on apoptosis in macrophages stimulated by oxLDL.Q39597464
The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.Q39875341
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis.Q40076818
Monocyte cytokine secretion in patients with pulmonary tuberculosis differs from that of healthy infected subjects and correlates with clinical manifestationsQ40541640
Levels of interferon-gamma and interleukin-2 receptor-alpha for bronchoalveolar lavage fluid and serum were correlated with clinical grade and treatment of pulmonary tuberculosisQ40577536
Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stressQ40613314
Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis.Q40813543
Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cellsQ41471673
IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection.Q41764389
Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strainsQ41961229
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cellsQ42139586
Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3.Q42226368
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signalingQ42416289
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.Q42943512
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritationQ42971196
IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivoQ42971329
Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonrespondersQ42997948
Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosisQ44064936
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosisQ44201389
Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosisQ44266163
Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma productionQ44354846
Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosisQ44390333
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.Q44453951
Depletion of IL-22 during culture enhanced antigen-driven IFN-γ production by CD4(+)T cells from patients with active TB.Q45246028
Negative and Positive Predictive Value of a Whole-Blood Interferon-γ Release Assay for Developing Active TuberculosisQ46093848
Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritisQ46431604
Increased specific T cell cytokine responses in patients with active pulmonary tuberculosis from Central AfricaQ46502655
Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production.Q47694485
T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis.Q47969507
Reactivation of tuberculosis is associated with a shift from type 1 to type 2 cytokinesQ48245059
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.Q21034169
Interleukin-10 and the interleukin-10 receptorQ24290912
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
Update on latent tuberculosis infectionQ26828541
A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivoQ27349862
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cellsQ28590243
Interleukin-21: Basic Biology and Implications for Cancer and AutoimmunityQ29042353
Interaction between HIV and Mycobacterium tuberculosisQ29397094
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesQ29547420
Immunology of tuberculosisQ29614370
Differentiation of effector CD4 T cell populations (*)Q29614838
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionQ29616521
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophagesQ29617356
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Disseminated tuberculosis in interferon gamma gene-disrupted miceQ29619812
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Regulatory T cells: mechanisms of differentiation and functionQ29620731
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in miceQ29622922
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.Q30438825
Surprisingly high specificity of the PPD skin test for M. tuberculosis infection from recent exposure in The GambiaQ30828531
Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatmentQ33265416
The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzleQ33339582
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory functionQ33730136
Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice.Q33748060
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.Q50671032
Development of miliary tuberculosis related to anti-tumor necrosis factor-alpha inhibitor therapy for pustular psoriasis.Q50941807
Keeping STATs on memory CD8+ T cells.Q50981205
Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.Q51316721
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.Q51824660
Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis.Q51838282
Increased frequency of CD4(+)CD25(high) Treg cells inhibit BCG-specific induction of IFN-gamma by CD4(+) T cells from TB patients.Q51971728
IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection.Q51980500
Characterization of the memory/activated T cells that mediate the long-lived host response against tuberculosis after bacillus Calmette-Guérin or DNA vaccination.Q52032470
Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.Q52534366
Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3.Q52927400
Polarization of PPD-specific T-cell response of patients with tuberculosis from Th0 to Th1 profile after successful antimycobacterial therapy or in vitro conditioning with interferon-alpha or interleukin-12.Q52927700
Increased Th1 and Th2 type cytokine production in patients with active tuberculosis.Q53025059
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.Q53446140
Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis.Q53668976
Therapy of tuberculosis in mice by DNA vaccination.Q54085325
Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin.Q54198243
Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigensQ56828019
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponsesQ56904642
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
Depressed T‐Cell Interferon‐γ Responses in Pulmonary Tuberculosis: Analysis of Underlying Mechanisms and Modulation with TherapyQ58329499
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeQ58518610
Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with TuberculosisQ58826841
Restoration of mycobacterial antigen-induced proliferation and interferon-γ responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapyQ58827836
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
Inactivation of CD4+ CD25+ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen loadQ59050560
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis PatientsQ61885691
Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine productionQ70527759
Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosisQ71764410
T cell-derived IL-10 antagonizes macrophage function in mycobacterial infectionQ71929941
Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesionsQ72896100
Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavitiesQ73556652
Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvementQ73626386
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondiiQ73755946
IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in miceQ74467274
Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapyQ77204273
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosisQ77399349
Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosisQ77437186
Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapyQ77828348
Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosisQ78687288
Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infectionQ79929535
IL-9 is associated with an impaired Th1 immune response in patients with tuberculosisQ79933186
Interferon gamma/IL10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosisQ80391038
Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon-gamma recovery and reduction of lung injuryQ80454652
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progressionQ80523271
Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T CellsQ82282261
A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosisQ82853651
Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cellsQ83477958
T regulatory cells and Th1/Th2 cytokines in peripheral blood from tuberculosis patientsQ83816784
IL-10 inhibits apoptosis and microvesiculation of human monocytesQ84166116
DNA vaccinesQ93896322
IL-4 in tuberculosis: implications for vaccine designQ35868740
What's good for the host is good for the bug.Q36057658
TNF-blocking agents and tuberculosis: new drugs illuminate an old topicQ36059141
Notch controls the magnitude of T helper cell responses by promoting cellular longevity.Q36061611
Heat-shock proteins induce T-cell regulation of chronic inflammationQ36085622
IL-2 simultaneously expands Foxp3+ T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector cooperation in immunity to TB.Q36142227
DNA vaccines: progress and challengesQ36186005
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasisQ36229713
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subsetQ36277359
High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.Q36362685
IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccinationQ36375426
The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in miceQ36376221
Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune responseQ36416118
Notch regulates IL-10 production by T helper 1 cellsQ36491342
Immune factors and immunoregulation in tuberculosisQ36673984
Natural regulatory T cells: mechanisms of suppressionQ36719995
T(H)1 cells control themselves by producing interleukin-10.Q36831662
Innate and adaptive immunity through autophagyQ36896712
Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cellsQ37137636
Resident Th1-like effector memory cells in pulmonary recall responses to Mycobacterium tuberculosisQ37273816
BCG and BCG/DNAhsp65 vaccinations promote protective effects without deleterious consequences for experimental autoimmune encephalomyelitisQ37316205
DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.Q37368644
IL-21 mediates suppressive effects via its induction of IL-10.Q37373090
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages.Q37463450
Identification of immunological biomarkers which may differentiate latent tuberculosis from exposure to environmental nontuberculous mycobacteria in childrenQ37545011
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.Q37866633
The role of Notch in the differentiation of CD4⁺ T helper cellsQ38015257
The immune response in tuberculosisQ38091698
Risk of tuberculosis infection in anti-TNF-α biological therapy: from bench to bedsideQ38111161
Autophagy as an immune effector against tuberculosisQ38116134
In search of a new paradigm for protective immunity to TBQ38192925
Chromatin-level regulation of the IL10 gene in T cells.Q38337531
Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisyQ33916768
IL-10 production by CD4+ effector T cells: a mechanism for self-regulationQ33927028
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivationQ33996487
Dichotomy of cytokine profiles in patients and high-risk healthy subjects exposed to tuberculosisQ34002304
Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathologyQ34006525
Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitisQ34008352
Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylationQ34031817
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosisQ34044493
Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity.Q34127776
Differentiation and recruitment of Th9 cells stimulated by pleural mesothelial cells in human Mycobacterium tuberculosis infectionQ34171286
Mycobacterium bovisBCG-Specific Th17 Cells Confer Partial Protection againstMycobacterium tuberculosisInfection in the Absence of Gamma InterferonQ34177268
Interleukin-10 inhibits apoptotic cell death in infectious mononucleosis T cellsQ34235308
Different patterns of cytokines and chemokines combined with IFN-γ production reflect Mycobacterium tuberculosis infection and diseaseQ34427734
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosisQ34431001
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableQ34432140
Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10.Q34435508
Type 1 T regulatory cells.Q34448429
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Genetic dissection of immunity to mycobacteria: the human modelQ34542276
Multiplex analysis of cytokines/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settingsQ34581606
Innate immunity to Mycobacterium tuberculosisQ34587177
IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infectionQ34608524
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cellsQ34609504
Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infectionQ34615073
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical managementQ34648346
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
T Cell Activation and Proinflammatory Cytokine Production in Clinically Cured Tuberculosis Are Time-Dependent and Accompanied by Upregulation of IL-10.Q34793513
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseQ34995059
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infectionsQ35205539
T-cell cytokine responses in human infection with Mycobacterium tuberculosisQ35433339
Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infectionQ35441389
Absence of a prominent Th2 cytokine response in human tuberculosisQ35483311
Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosisQ35563366
IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infectionQ35737807
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
cytokineQ212354
tuberculosisQ12204
helper-inducer T-lymphocytesQ65983548
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)639107
P577publication date2015-10-01
P1433published inJournal of Immunology ResearchQ26841936
P1476titleComplexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis
P478volume2015

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