IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

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IL-10 production by CD4+ effector T cells: a mechanism for self-regulation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1014368199
P356DOI10.1038/MI.2010.8
P932PMC publication ID4105209
P698PubMed publication ID20200511
P5875ResearchGate publication ID41722319

P2093author name stringA Sher
D Jankovic
D G Kugler
P2860cites workPotential role for interleukin-10 in the immunosuppression associated with kala azarQ24594397
T follicular helper cells differentiate from Th2 cells in response to helminth antigensQ24645365
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cellsQ24655629
A critical role for IL-21 in regulating immunoglobulin productionQ28215868
Interleukin-10Q28263225
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cellsQ28590243
Interleukin-21: Basic Biology and Implications for Cancer and AutoimmunityQ29042353
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
IL-10 inhibits cytokine production by activated macrophagesQ29619453
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.Q30438825
Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malariaQ33426367
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infectionQ33624096
c-Maf regulates IL-10 expression during Th17 polarizationQ33709726
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivationQ33996487
Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitisQ34008352
The complex role of interleukin-10 in autoimmunityQ34203672
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.Q34566731
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cellsQ34609504
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitisQ34719541
CD4 T cells: fates, functions, and faultsQ34813153
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseQ34995059
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brainQ35037296
CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infectionQ35122182
Dendritic cells in immunity and tolerance-do they display opposite functions?Q35181775
Plasmacytoid dendritic cells in immunityQ35953140
Cytokines and Ly-1 (B1) B cellsQ36196196
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigensQ36228356
Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasisQ36229304
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasisQ36229713
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosisQ36376986
Toll-like receptor recognition of Toxoplasma gondii.Q36395772
Extended IL10 haplotypes and their association with HIV progression to AIDS.Q36878917
T follicular helper (TFH) cells in normal and dysregulated immune responsesQ37049341
Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance.Q37120690
Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cellsQ37137636
Stat4-dependent, T-bet-independent regulation of IL-10 in NK cellsQ37210723
Cytokine-secreting follicular T cells shape the antibody repertoireQ37270592
IL-21 mediates suppressive effects via its induction of IL-10.Q37373090
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.Q37386071
Nonredundant roles for B cell-derived IL-10 in immune counter-regulationQ37409360
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cellsQ37484974
Chromatin-level regulation of the IL10 gene in T cells.Q38337531
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.Q39594770
Reprogramming of IL-10 activity and signaling by IFN-gamma.Q40618355
Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.Q42074930
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human bloodQ42572213
Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligandQ42767299
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritationQ42971196
IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivoQ42971329
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingQ45069275
Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infectionQ45409693
Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirusQ47261209
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionQ47388000
Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infectionQ48034047
Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.Q51782134
Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection.Q52522603
Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.Q52906696
Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3.Q52927400
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.Q53446140
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.Q53587595
The role of IL-12 in maintaining resistance to Leishmania major.Q53669928
Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.Q53863572
Helminth infection protects mice from anaphylaxis via IL-10-producing B cells.Q53880583
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Q54195040
Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production.Q54468107
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.Q54709609
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.Q55045567
Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphismQ56453101
In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsivenessQ56899837
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Q56930023
IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic diseaseQ57339957
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis PatientsQ61885691
Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine productionQ70527759
Interleukin-10 is localized to and released by human lung mast cellsQ73080012
Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In VivoQ73407790
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondiiQ73755946
Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondiiQ73948679
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patientsQ79713020
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokinesQ81119942
Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene clusterQ81512281
Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cellsQ81546488
P433issue3
P304page(s)239-246
P577publication date2010-03-03
P1433published inMucosal ImmunologyQ15817743
P1476titleIL-10 production by CD4+ effector T cells: a mechanism for self-regulation
P478volume3

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