T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation

scientific article published on 8 November 2004

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20041789
P932PMC publication ID2211912
P698PubMed publication ID15534372
P5875ResearchGate publication ID8187277

P50authorKlaus RajewskyQ126992
Werner MüllerQ2562110
P2093author name stringAchim D Gruber
Thomas Krieg
Werner Stenzel
Dirk Schlüter
Martina Deckert
Axel Roers
Lisa Siewe
Elke Strittmatter
P2860cites workDifferential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cellsQ73612987
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulationQ77704355
Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10Q78804319
Interleukin-10 and the interleukin-10 receptorQ24290912
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanismsQ24673863
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytesQ29619621
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Helicobacter ganmani sp. nov., a urease-negative anaerobe isolated from the intestines of laboratory miceQ30662184
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanismQ33767365
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Regulatory T cells in autoimmmunity*.Q33904108
Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammationQ34008033
Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitisQ34008352
B cells regulate autoimmunity by provision of IL-10.Q34150590
Regulatory T cells in the control of immune pathology.Q34348983
Control of T-cell activation by CD4+ CD25+ suppressor T cellsQ34448423
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondiiQ35495758
In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel diseaseQ35753115
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussiQ36369855
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cellsQ36375116
Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunityQ36401161
Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathwaysQ40702335
Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10.Q41103457
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.Q42930229
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responsesQ42943035
Toxoplasma encephalitis of immunocompetent and nude mice: immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene productsQ43630121
Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.Q45306726
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.Q47777664
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.Q51069614
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis.Q54008245
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
Identification and induction of keratinocyte-derived IL-10Q68159676
TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing miceQ71829081
IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in miceQ71928347
Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivoQ73368144
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
lipopolysaccharideQ421804
P304page(s)1289-1297
P577publication date2004-11-08
P1433published inJournal of Experimental MedicineQ3186912
P1476titleT cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
P478volume200

Reverse relations

cites work (P2860)
Q526076151,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis.
Q92845228A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma
Q37386071A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Q42243816A protective role for human IL-10-expressing CD4+ T cells in colitis.
Q92767575Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Q34954366Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells
Q36294669Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice
Q38648169Antigen-specific regulatory T-cell responses to intestinal microbiota
Q54235586Assessment of the antigenic and neuroprotective activity of the subunit anti-Toxoplasma vaccine in T. gondii experimentally infected mice.
Q35658606B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice
Q37386065BAC talk about cell type-specific regulation of human IL-10.
Q35893711Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.
Q64228378Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Q35143581Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii
Q33730136CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
Q34789335CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function
Q48232420Cardiac macrophages promote diastolic dysfunction.
Q37678256Cell type-specific regulation of IL-10 expression in inflammation and disease
Q50048575Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.
Q27025911Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut
Q26779956Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis
Q50621517Contact allergens induce CD8+ T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity.
Q37106740Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
Q36229731Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.
Q89448413Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses
Q35237502Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease
Q36709991Cytokine regulation of immunopathology in toxoplasmosis
Q27007128Cytokine reporter mice: the special case of IL-10
Q37133450Cytokine signaling modules in inflammatory responses
Q40294312DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4+IL-10+ Regulatory T Cells during Plasmodium yoelii Infection
Q39611565Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice
Q37405187Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin
Q47304997Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases
Q30489747Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation
Q43420803Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo.
Q37374961Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation.
Q57056971Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis
Q35187144Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice
Q36422047Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection
Q37618990Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice
Q40110847Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.
Q50027164Essential immunologic orchestrators of intestinal homeostasis.
Q37619881Essential role of IL-10/STAT3 in chronic stress-induced immune suppression
Q35618798Experimental Models of Inflammatory Bowel Diseases
Q37104701Foxp3 processing by proprotein convertases and control of regulatory T cell function
Q34515848From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
Q42731419Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter
Q37731297Host-derived nitrate boosts growth of E. coli in the inflamed gut
Q36295242Host-microbiota interactions in inflammatory bowel disease
Q41958567IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases
Q37362590IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine.
Q40929447IL-10 control of dendritic cells in the skin.
Q40844847IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites
Q33927028IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
Q36237672IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut
Q35597423IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis
Q35737807IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
Q38341386Identification and putative roles of distinct subtypes of intestinal dendritic cells in neuroimmune communication: what can be learned from other organ systems?
Q29994840Imaging protective mast cells in living mice during severe contact hypersensitivity
Q24612341Immune response and immunopathology during toxoplasmosis
Q36212828Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection
Q37883443Inflamed gut mucosa: downstream of interleukin-10.
Q29615500Inflammatory bowel disease
Q33966409Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
Q36543665Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans
Q57339917Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
Q47605327Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response.
Q35187588Interleukin-10 from T cells, but not macrophages and granulocytes, is required for chronic disease in Leishmania mexicana infection
Q37578470Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds
Q41916760Interleukin-10 production by effector T cells: Th1 cells show self control
Q34936014Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
Q36472866Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation
Q35714248Interrelatedness between dysbiosis in the gut microbiota due to immunodeficiency and disease penetrance of colitis
Q37700728Intestinal bacteria and the regulation of immune cell homeostasis
Q37600191Intestinal effector T cells in health and disease.
Q37642857Intestinal immune regulation as a potential diet-modifiable feature of gut inflammation and autoimmunity
Q36035917Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease
Q42049743Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.
Q37721150Langerhans cells: critical regulators of skin immunity?
Q79983205Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response
Q27014858Linking vitamin d deficiency to inflammatory bowel disease
Q37288927Macrophage and T cell produced IL-10 promotes viral chronicity
Q40104157Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling
Q26851960Macrophages in intestinal homeostasis and inflammation
Q64110701Maf deficiency in T cells dysregulates T - T17 balance leading to spontaneous colitis
Q36071413Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease
Q33553714Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function
Q93090557Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases
Q92845952Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells
Q58769405Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
Q50671091Molecular Mechanisms of Regulatory T Cell Development and Suppressive Function
Q36041225Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling
Q44088969Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
Q60315851NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms
Q39738126NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Q91708029Natural Killer Cell-Derived IL-10 Prevents Liver Damage During Sustained Murine Cytomegalovirus Infection
Q37133882New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
Q37409360Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
Q36605144Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD)
Q36463118Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Q34045043Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta
Q34045485Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Q93380331RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation
Q38937349Rare phenotypes in the understanding of autoimmunity
Q34033579Reciprocal interactions of the intestinal microbiota and immune system.
Q56987400Regula'ten' the gut
Q26766184Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
Q38979322Regulation of Interleukin-10 Expression
Q30409386Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?
Q42203314Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response
Q34789108Regulatory T cells and immune tolerance in the intestine
Q80785928Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
Q35207335Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
Q30244203Role of Tregs in Cancer Dormancy or Recurrence
Q34262223Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease
Q38109528Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus.
Q27021181Role of interleukin-10 in malaria: focusing on coinfection with lethal and nonlethal murine malaria parasites
Q81578755Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
Q37484974Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells
Q38163336Systems biology of primary CNS lymphoma: from genetic aberrations to modeling in mice
Q36957148T Cell-Associated Cytokines in the Pathogenesis of Sjögren's Syndrome
Q38742184T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
Q51709154T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation.
Q34795494T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine
Q36945768T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis
Q36567445T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine
Q39039120T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice
Q28513789TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
Q38010707The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling
Q38128816The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
Q46835576The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1.
Q58417804The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10
Q37640488The aryl hydrocarbon receptor promotes IL-10 production by NK cells
Q36336588The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
Q38281273The dual nature of interleukin-10 in pemphigus vulgaris
Q37968293The effects of commensal microbiota on immune cell subsets and inflammatory responses
Q26863747The gut mucosal immune response to Toxoplasma gondii
Q35591962The microbiome in infectious disease and inflammation
Q34533142The microbiota in adaptive immune homeostasis and disease
Q52923839The pro- and anti-inflammatory potential of IL-12: the dual role of Th1 cells.
Q29615479The regulation of IL-10 production by immune cells
Q44459161The soluble tachyzoite antigen of Toxoplasma gondii has a protective effect on mouse allografts
Q24298841The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
Q36050870Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia
Q37812686Treg cell–IgA axis in maintenance of host immune homeostasis with microbiota
Q37371476Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.
Q37546521Vaccinated C57BL/6 mice develop protective and memory T cell responses to Coccidioides posadasii infection in the absence of interleukin-10.
Q89965819c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes

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