Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

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Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1019054629
P356DOI10.1038/MI.2014.64
P698PubMed publication ID25027601

P2093author name stringM L Kapsenberg
E C de Jong
G Bakdash
L T C Vogelpoel
T M M van Capel
P2860cites workIntestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8.Q42358047
Vitamin A and carotene: The absence of the liver oil vitamin A from carotene. VI. The conversion of carotene to vitamin A in vivoQ42572892
MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cellsQ42786302
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All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cellsQ43250169
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acidQ43283588
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityQ44808056
Circulating endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate.Q45144433
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.Q45943518
Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.Q47783598
Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T CellsQ59336226
Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing SignalsQ63362699
Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytesQ73199893
Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytesQ80005299
TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-betQ81724302
Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cellsQ83880996
The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptorQ24309259
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient miceQ24523182
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early deathQ24563654
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory diseaseQ28202655
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
Retinoic acid imprints gut-homing specificity on T cellsQ29619126
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy miceQ30440063
Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytesQ33264230
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.Q33361113
Biology of interleukin-10.Q34152272
Type 1 T regulatory cells.Q34448429
IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomenaQ34468346
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulationQ34580976
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseQ34995059
Intestinal lamina propria dendritic cell subsets have different origin and functions.Q35001346
Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cellsQ35087813
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.Q35456744
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in miceQ35568115
The role of retinoic acid in tolerance and immunityQ36162881
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiationQ36369726
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cellsQ37106740
Regulatory T cells in inflammatory bowel diseaseQ37363153
Inflammatory bowel disease and mutations affecting the interleukin-10 receptorQ37454505
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cellsQ38008355
Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complexQ39621420
Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patternsQ39943932
Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.Q41015067
GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacityQ41870391
Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acidQ42033052
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent mannerQ42107193
P433issue2
P921main subjecttretinoinQ29417
dendritic cellQ506253
P304page(s)265-278
P577publication date2014-07-16
P1433published inMucosal ImmunologyQ15817743
P1476titleRetinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
P478volume8

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cites work (P2860)
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