IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection

scientific article published on 28 December 2011

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1102755
P932PMC publication ID3272378
P698PubMed publication ID22205023
P5875ResearchGate publication ID51977244

P50authorWerner MüllerQ2562110
Anne O'GarraQ4768689
Jean LanghorneQ47903854
P2093author name stringAna Paula Freitas do Rosário
Axel Roers
Tracey Lamb
Robin Stephens
Agathe Lang
Philip Spence
P2860cites workInterleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNAQ57339917
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaQ57339973
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of ColitisQ61779891
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansionQ81111400
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cellsQ81578755
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28Q22001503
Interleukin-10 and the interleukin-10 receptorQ24290912
Interleukin-10 determines viral clearance or persistence in vivoQ27486832
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malariaQ28476346
Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ28591931
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
The regulation of IL-10 production by immune cellsQ29615479
Mechanisms of foxp3+ T regulatory cell-mediated suppressionQ29615842
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.Q30438825
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infectionQ33327498
Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malariaQ33426367
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.Q33540173
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopNQ33590435
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretionQ33604905
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infectionQ33624096
CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivoQ33775493
IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infectionQ33882890
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitisQ33966409
A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in miceQ34001680
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfacesQ34590015
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cellsQ34609504
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitisQ34713380
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasisQ34792941
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseQ34995059
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expressionQ35474954
Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10-deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodiesQ35801788
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigensQ36228356
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasisQ36229713
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAEQ36340416
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian childrenQ36345204
Advances in understanding the anti-inflammatory properties of IL-27.Q37124028
IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infectionQ37359046
Nonredundant roles for B cell-derived IL-10 in immune counter-regulationQ37409360
Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy conQ37523995
IL-21 is an immune activator that also mediates suppression via IL-10.Q37822815
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.Q39004614
B lymphocyte-specific, Cre-mediated mutagenesis in miceQ39719513
Interleukin-10 production by effector T cells: Th1 cells show self controlQ41916760
Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.Q42024502
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human bloodQ42572213
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritationQ42971196
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.Q44554898
Low plasma concentrations of interleukin-10 in severe malarial anaemia compared with cerebral and uncomplicated malaria.Q46508015
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cellsQ46798648
Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigensQ46823479
Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.Q47889064
Migrating monocytes recruited to the spleen play an important role in control of blood stage malariaQ47916546
Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infectionQ48034047
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.Q51765584
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetesQ56904806
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Q56930023
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
P304page(s)1178-1190
P577publication date2011-12-28
P1433published inJournal of ImmunologyQ3521441
P1476titleIL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
P478volume188

Reverse relations

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