Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo

scientific article published on 22 July 2014

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1028092699
P356DOI10.1038/ICB.2014.60
P698PubMed publication ID25047644

P2093author name stringNick Carpino
Satya P Kunapuli
Alexander Y Tsygankov
Doina Ganea
Elisabetta Liverani
Elitza Ivanova
Fayez Safadi
Gian L Russo
Tiffanny N Newman
P2860cites workTyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckQ22009540
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RQ24297906
A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in plateletsQ24336773
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing proteinQ24540267
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligoQ24629443
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunityQ24642507
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3Q24644978
A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR SignalingQ27646954
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and traffickingQ28208563
c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPasesQ28213787
Interleukin-12 and Th1 immune response in Crohn's disease: pathogenetic relevance and therapeutic implicationQ28265856
Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cellsQ28288275
TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast functionQ28586059
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2Q28587191
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsQ28609046
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared lociQ28943258
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetesQ29417127
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Innate lymphoid cells--a proposal for uniform nomenclatureQ29617431
Phenotypic and functional features of human Th17 cellsQ29619323
Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.Q30009882
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinasesQ30164059
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitinQ30164133
Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domainsQ30168322
Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profileQ33301251
Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 SubstrateQ33645197
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activationQ33890664
Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contactQ34008299
Targeting delivery of anti-TNFalpha oligonucleotide into activated colonic macrophages protects against experimental colitisQ43232770
T-cell regulation of neutrophil infiltrate at the early stages of a murine colitis modelQ43284324
Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat.Q43568780
Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responsesQ44081504
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitisQ44247183
Galectin-1 suppresses experimental colitis in miceQ44429812
Analysis of the T cell receptor V beta repertoire in 2,4,6-trinitrobenzenesulfonic acid induced colitis in miceQ44508604
Intracellular Phospho-Flow cytometry reveals novel insights into TCR proximal signaling events. A comparison with Western blotQ44540296
Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitisQ45242443
The presentation of haptenated proteins and activation of T cells in the mesenteric lymph nodes by dendritic cells in the TNBS colitis rat.Q45245012
All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.Q45991876
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cellsQ46043684
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.Q46257713
Detrimental role for CD4+ T lymphocytes in murine diffuse peritonitis due to inhibition of local bacterial eliminationQ46927831
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.Q47777664
Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis.Q51825944
FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.Q51983634
Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells.Q51986019
Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.Q54074094
IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo.Q54388635
Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.Q54471973
Predominant pathogenic role of tumor necrosis factor in experimental colitis in miceQ59276550
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis PatientsQ61885691
Preincubation with anti-CD4 influences activation of human T cells by subsequent co-cross-linking of CD4 with CD3Q63859664
Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in miceQ73098249
Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitisQ74303616
Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signalingQ74485131
The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axisQ80428039
Mouse models of inflammatory bowel diseaseQ81158539
Critical role of IL-17 receptor signaling in acute TNBS-induced colitisQ83276931
Translating inflammatory bowel disease research into clinical medicineQ84573739
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell helpQ34064488
Therapeutic and prophylactic thalidomide in TNBS-induced colitis: synergistic effects on TNF-alpha, IL-12 and VEGF productionQ34098863
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseasesQ34181228
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cellsQ34299001
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.Q34321127
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid miceQ34321778
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitisQ34575334
T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosisQ34665121
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Effect of a CD4-depleting antibody on the development of Cryptococcus neoformans-induced allergic bronchopulmonary mycosis in miceQ34721178
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathwaysQ34963266
Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association studyQ34980995
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.Q36229731
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.Q36362779
Antibodies to interleukin 12 abrogate established experimental colitis in miceQ36365464
Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevanceQ36809886
Induction and regulation of inflammatory bowel disease in immunodeficient mice by distinct CD4+ T-cell subsets.Q36944574
The histidine phosphatase superfamily: structure and functionQ37037661
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitisQ37098695
Multidomain STS/TULA proteins are novel cellular regulatorsQ37111363
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cellsQ37242180
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.Q37280352
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanismQ37325464
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.Q37448373
TULA-family proteins: an odd coupleQ37544376
Intestinal effector T cells in health and disease.Q37600191
Regulatory T cells reinforce intestinal homeostasisQ37600194
Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel diseaseQ37633430
TULA-family proteins: a new class of cellular regulatorsQ38017998
Innate lymphoid cells--how did we miss them?Q38071916
Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent apoptosis of T lymphocytesQ40579458
Modulation of neutrophil motility by curcumin: implications for inflammatory bowel diseaseQ41858578
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.Q41904687
Interleukin-23 drives intestinal inflammation through direct activity on T cellsQ42083897
Chemically induced mouse models of intestinal inflammationQ42510602
P433issue10
P304page(s)837-850
P577publication date2014-07-22
P1433published inImmunology & Cell BiologyQ13731918
P1476titleMembers of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo
P478volume92

Reverse relations

cites work (P2860)
Q55510136Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.
Q33427174Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
Q64360608Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins
Q39178438Genetics of primary sclerosing cholangitis and pathophysiological implications
Q90006694Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach
Q64991646Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.
Q93092263TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists
Q28854385TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
Q48290135UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-κB Signaling
Q97643346UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice

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