Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

scientific article published on 01 August 2019

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2019.07.034
P932PMC publication ID6711398
P698PubMed publication ID31412245

P50authorGabrielle BelzQ17517003
Stephen L. NuttQ42651674
Fernando Souza-Fonseca-GuimaraesQ56783216
Nicholas D HuntingtonQ59559817
Fanny LafouresseQ64495966
Lucy CooperQ90307295
Amania SheikhQ90307297
P2093author name stringJames J Moon
Kim L Good-Jacobson
Marc Pellegrini
Joanna R Groom
Brigette C Duckworth
Meiqi Feng
P2860cites workT-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B CellsQ91928248
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathwayQ24563655
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsQ24595285
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
Bcl6 mediates the development of T follicular helper cellsQ28252825
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileQ28508595
T-bet regulates IgG class switching and pathogenic autoantibody productionQ28588979
Protective neutralizing influenza antibody response in the absence of T follicular helper cellsQ30394708
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiationQ33829736
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) DifferentiationQ33851778
T-cell subsets in the germinal center.Q34327596
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cellsQ34973705
Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenzaQ35023393
The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosaQ35111225
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cellsQ35197906
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanismsQ35289219
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.Q35525803
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cellsQ35607142
Early Th1 cell differentiation is marked by a Tfh cell-like transitionQ35630458
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiationQ35991917
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORαQ35996123
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infectionQ36073682
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factorQ36082833
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.Q36229658
Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infectionQ36239323
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.Q36286032
IL-7 signalling represses Bcl-6 and the TFH gene program.Q36511197
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responsesQ37029283
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearanceQ37117949
Cytokine-secreting follicular T cells shape the antibody repertoireQ37270592
Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cellsQ37711709
Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory.Q38370894
T follicular helper cells in space-time.Q38940412
Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune SystemQ39171638
Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral InfectionQ39588420
c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody ResponsesQ40236309
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell DifferentiationQ40847543
ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6Q42136332
Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infectionQ45757704
STAT4 and T-bet control follicular helper T cell development in viral infections.Q47355847
The development and fate of follicular helper T cells defined by an IL-21 reporter mouseQ50499734
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitmentQ50736370
Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in HumansQ51636129
Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes.Q55030447
TCR signal strength controls the differentiation of CD4 effector and memory T cellsQ58194484
PD-1 Controls Follicular T Helper Cell Positioning and FunctionQ58730207
The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral InfectionQ64102236
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.Q64882534
Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-betQ77476285
Ki67 is a Graded Rather than a Binary Marker of Proliferation versus QuiescenceQ90691541
Transient T-bet expression functionally specifies a distinct T follicular helper subsetQ91553929
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)1758-1772.e4
P577publication date2019-08-01
P1433published inCell ReportsQ5058165
P1476titleContext-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
P478volume28

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Q100395393Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitmentcites workP2860

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