Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection

scientific article (publication date: 29 November 2010)

Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...513972W
P356DOI10.1371/JOURNAL.PONE.0013972
P3181OpenCitations bibliographic resource ID2164670
P932PMC publication ID2993933
P698PubMed publication ID21124769
P5875ResearchGate publication ID49651838

P50authorBaozhong WangQ50995570
Richard W. CompansQ45412816
P2093author name stringLi Wang
Rui Xu
Sang-Moo Kang
Fu-Shi Quan
P2860cites workThe evolution of human influenza virusesQ24522380
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Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza virusesQ46737829
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.Q50060542
Synthetic recombinant influenza vaccine induces efficient long-term immunity and cross-strain protectionQ50140873
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivoQ56904232
Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvantsQ73980726
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motilityQ28185475
Activation of interleukin-1 receptor-associated kinase by gram-negative flagellinQ28201436
Regulation of interferon-gamma during innate and adaptive immune responsesQ28256001
Cross-protection against lethal H5N1 challenge in ferrets with an adjuvanted pandemic influenza vaccineQ30229190
Heterosubtypic immunity against human influenza A viruses, including recently emerged avian H5 and H9 viruses, induced by FLU-ISCOM vaccine in mice requires both cytotoxic T-lymphocyte and macrophage functionQ30233581
Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infectionQ30328172
Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice.Q30332972
Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus.Q30359424
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Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses.Q30372024
MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization.Q30382567
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Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.Q35277985
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Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B.Q36464264
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Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virusQ39584981
Hemagglutination-inhibition: rapid assay for neuraminic acid-containing virusesQ40632706
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexesQ40641430
Flagellin fusion proteins as adjuvants or vaccines induce specific immune responsesQ40763973
Murine model for evaluation of protective immunity to influenza virusQ45774092
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectimmunizationQ1415366
P304page(s)e13972
P577publication date2010-11-29
P1433published inPLOS OneQ564954
P1476titleIntranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection
P478volume5

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