Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants

scientific article published on 01 June 2001

Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0264-410X(01)00088-3
P698PubMed publication ID11395211

P2093author name stringJ D Clements
M J McCluskie
H L Davis
R D Weeratna
P2860cites workCpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gammaQ24568172
CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young miceQ33597242
Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routesQ33784161
Immunization against hepatitis B virus by mucosal administration of antigen-antibody complexesQ33857473
Mucosally induced immunoglobulin E-associated inflammation in the respiratory tractQ34003245
CpG motifs in bacterial DNA trigger direct B-cell activationQ34307394
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticityQ36377098
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunityQ36770993
Effective immunity to dental caries: enhancement of salivary anti-Streptococcus mutans antibody responses with oral adjuvantsQ37111929
Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.Q39570111
Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systemsQ40788029
Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen.Q40790811
TH2-type cytokines in asthmaQ41200649
Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigenQ45753076
CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virusQ45754574
Effect of MDP-Lys(L18) as a mucosal immunoadjuvant on protection of mucosal infections by Sendai virus and rotavirusQ45768651
Immunostimulatory DNA is a potent mucosal adjuvantQ46476023
Recombinant cholera toxin B subunit acts as an adjuvant for the mucosal and systemic responses of mice to mucosally co-administered bovine serum albuminQ48026935
LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.Q50131343
Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine.Q54627789
Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine.Q54636789
CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma☆☆☆★Q60147719
The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activityQ67542118
Oral adjuvants enhance IgA responses to Streptococcus mutansQ70303200
Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alphaQ70866576
Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxinQ71643281
The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)Q73028927
CpG DNA as mucosal adjuvantQ73042328
Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifsQ73407815
CpG DNA induces stronger immune responses with less toxicity than other adjuvantsQ73502903
Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12Q73561535
Stimulation of local immunity and protection in mice by intramuscular immunization with triple- or double-layered rotavirus particles and QS-21Q74401213
Mutational analysis of the role of ADP-ribosylation activity and GM1-binding activity in the adjuvant properties of the Escherichia coli heat-labile enterotoxin towards intranasally administered keyhole limpet hemocyaninQ74494513
Intranasal or subcutaneous co-administration of recombinant cholera toxin B subunit stimulates only a slight or no level of the specific IgE response in mice to tetanus toxoidQ74586086
Systemic and mucosal immune responses of mice to aluminium-adsorbed or aluminium-non-adsorbed tetanus toxoid administered intranasally with recombinant cholera toxin B subunitQ77132335
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P1104number of pages10
P304page(s)3759-3768
P577publication date2001-06-01
P1433published inVaccineQ7907941
P1476titleMucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants
P478volume19

Reverse relations

cites work (P2860)
Q33768109Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins
Q35585084CpG DNA: Trigger of Sepsis, Mediator of Protection, or Both?
Q37521856CpG adjuvant enhances the mucosal immunogenicity and efficacy of a Treponema pallidum DNA vaccine in rabbits
Q79847034CpG oligodeoxynucleotides and mobilization of innate mucosal immunity: tasks and tactics
Q57804907Crude saponins improve the immune response to an oral plant-made measles vaccine
Q41459314Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens
Q74765096Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODN
Q35671658Immunization with Heat Shock Protein A and γ-Glutamyl Transpeptidase Induces Reduction on the Helicobacter pylori Colonization in Mice
Q54492375Induction of serum and mucosal FIV-specific immune responses by intranasal immunization with p24Gag.
Q28744570Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection
Q40684882Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants
Q34572139Man the barrier! Strategic defences in the intestinal mucosa
Q33715999Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities
Q36055990Mucosal adjuvants
Q36517179Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity
Q44826911Multi-epitope DNA vaccine linked to the A2/B subunit of cholera toxin protect mice against Toxoplasma gondii
Q77526036Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccine
Q35689341Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants.
Q30394326Needle-free influenza vaccination.
Q37810816Progress towards a needle-free hepatitis B vaccine
Q33946563Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens.
Q44395938Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice.
Q34533990Robust immunity and heterologous protection against influenza in mice elicited by a novel recombinant NP-M2e fusion protein expressed in E. coli
Q35011950Study of capsular polysaccharide from Vibrio parahaemolyticus
Q35867213Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice

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