Mucosal adjuvants

scientific article

Mucosal adjuvants is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2004.11.010
P698PubMed publication ID15734046

P2093author name stringClements JD
Freytag LC
P2860cites workCpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gammaQ24568172
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifsQ24644853
The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in miceQ74586019
Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccinesQ74733696
Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coliQ27730290
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteriaQ29619620
Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infectionQ30328172
Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigenQ33591055
Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strainQ33599389
Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigsQ33604018
Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsetsQ33611559
Antibody-dependent and -independent protection following intranasal immunization of mice with rotavirus particlesQ33649920
Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein.Q33649962
Functional mapping of protective domains and epitopes in the rotavirus VP6 proteinQ33812420
Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA.Q33840918
Collaboration of epithelial cells with organized mucosal lymphoid tissues.Q33955758
Oral administration of influenza vaccine in combination with the adjuvants LT-K63 and LT-R72 induces potent immune responses comparable to or stronger than traditional intramuscular immunizationQ33999182
Genetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvantsQ34001658
Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections.Q34002470
Differential biological and adjuvant activities of cholera toxin and Escherichia coli heat-labile enterotoxin hybridsQ34006327
Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infectionQ34007563
Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosisQ34122078
Mechanisms of monophosphoryl lipid A augmentation of host responses to recombinant HagB from Porphyromonas gingivalisQ34126807
Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challengeQ34130795
Genetically manipulated bacterial toxin as a new generation mucosal adjuvantQ34184890
Immunomodulation using bacterial enterotoxinsQ34184898
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.Q34189195
Vaccination against Helicobacter pylori in non-human primate models and humansQ34222750
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDELQ34289590
CpG motifs in bacterial DNA trigger direct B-cell activationQ34307394
Activation of the immune system by bacterial CpG-DNA.Q34579763
Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvantsQ34639828
Role of Innate Immune Factors in the Adjuvant Activity of Monophosphoryl Lipid AQ34933694
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvantQ35476128
Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expressionQ36367736
Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infectionQ36369774
Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in miceQ37584470
Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.Q38303976
Induction of systemic immune responses to measles virus synthetic peptides administered intranasallyQ39055934
The adjuvant effect of a non-toxic mutant of heat-labile enterotoxin of Escherichia coli for the induction of measles virus-specific CTL responses after intranasal co-immunization with a synthetic peptideQ39340710
Inhibition of T-cell response by Escherichia coli heat-labile enterotoxin-treated epithelial cells.Q39517330
Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvantsQ39538202
Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvantQ39684976
Epithelial cells as sensors for microbial infectionQ39786521
Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activityQ39821844
Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: mode of action and augmenting effect of inflammatory cytokines.Q40269379
Contribution of the ADP-ribosylating and receptor-binding properties of cholera-like enterotoxins in modulating cytokine secretion by human intestinal epithelial cellsQ40746380
Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activityQ40843925
The role of Th1 and Th2 cells for mucosal IgA responses.Q40976411
Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cellsQ41561732
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissuesQ41850548
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activityQ41855397
Cholera toxin is exported from microsomes by the Sec61p complexQ41861735
The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigensQ41915577
Phospholipase A2 activating protein and idiopathic inflammatory bowel diseaseQ42000831
Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL.Q42833971
Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felisQ43702777
Targeting polymerised liposome vaccine carriers to intestinal M cellsQ43745138
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.Q43981500
Immunization onto bare skin with synthetic peptides: immunomodulation with a CpG-containing oligodeoxynucleotide and effective priming of influenza virus-specific CD4+ T cellsQ44191604
Induction of intestinal IgA and IgG antibodies preventing adhesion of verotoxin-producing Escherichia coli to Caco-2 cells by oral immunization with liposomesQ44311804
Adjuvant activity of the heat-labile enterotoxin from enterotoxigenic Escherichia coli for oral administration of inactivated influenza virus vaccineQ45018054
Active immunity and T-cell populations in pigs intraperitoneally inoculated with baculovirus-expressed transmissible gastroenteritis virus structural proteinsQ45746948
Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responsesQ45754936
Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coliQ47773545
Effects of intranasal administration of cholera toxin (or Escherichia coli heat-labile enterotoxin) B subunits supplemented with a trace amount of the holotoxin on the brainQ49046324
LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.Q50131343
Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens.Q51187990
Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection.Q51546562
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.Q52540113
Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants.Q53949766
Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.Q54540479
Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1.Q54560579
Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.Q54593091
Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera ToxinQ57180002
The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activityQ67542118
Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxinQ71643281
Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxinQ72845022
Cholera toxin adjuvant greatly promotes antigen priming of T cellsQ72921086
The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)Q73028927
Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniaeQ73188461
Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G)Q73502942
Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administrationQ73594822
ARF binds the C-terminal region of the Escherichia coli heat-labile toxin (LTA1) and competes for the binding of LTA2Q73732822
Characterization of the antibody response to pneumococcal glycoconjugates and the effect of heat-labile enterotoxin on IGg subclasses after intranasal immunizationQ73799949
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responsesQ73959658
Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvantsQ73980726
Immunogenicity of anti-Haemophilus influenzae type b CRM197 conjugate following mucosal vaccination with oligodeoxynucleotide containing immunostimulatory sequences as adjuvantQ74092627
Cholera toxin induces maturation of human dendritic cells and licences them for Th2 primingQ74165263
Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccineQ74484589
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)1804-1813
P577publication date2005-03-01
P1433published inVaccineQ7907941
P1476titleMucosal adjuvants.
P478volume23

Reverse relations

cites work (P2860)
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Q45384700Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles
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Q42174414Salmonella ghosts expressing enterotoxigenic Escherichia coli k88ab, k88ac, k99, and fasa fimbrial antigens induce robust immune responses in a mouse model
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Q33323372Sub-nucleocapsid nanoparticles: a nasal vaccine against respiratory syncytial virus
Q50041664Sublingual vaccination with sonicated Salmonella proteins and mucosal adjuvant induces mucosal and systemic immunity and protects mice from lethal enteritis
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Q37628867The ABC of clinical and experimental adjuvants--a brief overview
Q57945015The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT
Q26798471The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity
Q34532223The adjuvant double mutant Escherichia coli heat labile toxin enhances IL-17A production in human T cells specific for bacterial vaccine antigens
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Q36844715The perfect mix: recent progress in adjuvant research
Q49105055The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection
Q37791415Topical immunization strategies
Q42061615Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae
Q37130475Type I interferons as vaccine adjuvants against infectious diseases and cancer
Q37647549U-Omp19 from Brucella abortus Is a Useful Adjuvant for Vaccine Formulations against Salmonella Infection in Mice
Q35155937Unexpected modulation of recall B and T cell responses after immunization with rotavirus-like particles in the presence of LT-R192G.
Q27311087Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins
Q34594874Vaccines against enterotoxigenic Escherichia coli
Q34369729Vaccines against gonorrhea: current status and future challenges.
Q39159453WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant

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