Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity (scientific article)

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

Q24646764

DrugBank: a knowledgebase for drugs, drug actions and drug targets

Q24650300

CBP/p300-mediated acetylation of histone H3 on lysine 56

Q24657910

Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues

Q27683746

Chromatin modifications and their function

Q27861067

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

Q28118359

Duration of nuclear NF-kappaB action regulated by reversible acetylation

Q28215080

Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate

Q28278215

Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate

Q28343291

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

Q28609842

Inhibition of NF-kappa B by sodium salicylate and aspirin

Q29614708

Andromeda: a peptide search engine integrated into the MaxQuant environment

Q29615816

Type 2 diabetes as an inflammatory disease

Q29617184

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

Q29617188

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

Q29617192

Chemoproteomic profiling of lysine acetyltransferases highlights an expanded landscape of catalytic acetylation

Q34489555

Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins

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The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

Q35111527

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

Q35650662

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation.

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Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of

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Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids

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A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance

Q37101773

Histone acetyl transferases as emerging drug targets.

Q37540911

Life and death of transcriptional co-activator p300.

Q37897823

Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells

Q38288860

Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat

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AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300.

Q39469473

An electrophoretic mobility shift assay for the identification and kinetic analysis of acetyl transferase inhibitors

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24 Large-scale synthesis of coenzyme A esters

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NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants

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Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays

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Regulation of the p300 HAT domain via a novel activation loop.

Q42458138

CBP/p300 histone acetyl-transferase activity is important for the G1/S transition

Q42801428

Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: models for the 'second hit' hypothesis

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Regulation of activity of the transcription factor GATA-1 by acetylation

Q42823439

Small molecule modulators of histone acetyltransferase p300.

Q44353899

Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector

Q45864375

In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans.

Q51940716

Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding.

Q52171368

p300 is required for orderly G1/S transition in human cancer cells.

Q52572534

Pharmacokinetics of diflunisal in patients

Q70150437

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration

Q71059480

Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs

Q74097807

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

Q74614681

P407

language of work or name

English

Q1860

P921

main subject

salicylic acid

Q193572

P577

publication date

2016-05-31

P1433

published in

eLife

Q2000008

P1476

title

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

P478

volume

Reverse relations

cites work (P2860)

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