H. Robert Horvitz

American biologist

DBpedia resource is: http://dbpedia.org/resource/H._Robert_Horvitz

Abstract is: Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM (born May 8, 1947) is an American biologist best known for his research on the nematode worm Caenorhabditis elegans, for which he was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis of many diseases".

Born 1947-05-08 in Chicago (Q1297)

H. Robert Horvitz is …
instance of (P31):
humanQ5

External links are
P2381Academic Tree ID2848
P5019Brockhaus Enzyklopädie online IDhorvitz-robert-howard
P8179Canadiana Name Authority IDncf11618101
P11496CiNii Research ID1140000791687676800
P8313Den Store Danske IDH._Robert_Horvitz
P10565Encyclopedia of China (Third Edition) ID535313
P1417Encyclopædia Britannica Online IDbiography/H-Robert-Horvitz
P3219Encyclopædia Universalis IDrobert-horvitz
P2163FAST ID203666
P2070Fellow of the Royal Society ID11645
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P227GND ID1219888729
P12385Gran Enciclopèdia Catalana IDh.-robert-horvitz
P1296Gran Enciclopèdia Catalana ID (former scheme)0277147
P2924Great Russian Encyclopedia Online ID (old version)4696995
P7982Hrvatska enciklopedija ID68156
P269IdRef ID084997745
P213ISNI0000000053776858
P1438Jewish Encyclopedia ID (Russian)15822
P244Library of Congress authority IDn87846820
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P10242Lur Encyclopedic Dictionary ID02891/eu_h_2798/h2798
P549Mathematics Genealogy Project ID204394
P1284Munzinger person ID00000024292
P271NACSIS-CAT author IDDA09511020
P5380National Academy of Sciences member ID59418
P8189National Library of Israel J9U ID987007350808305171
P3222NE.se IDh-robert-horvitz
P691NL CR AUT IDxx0076956
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P1263NNDB people ID864/000135459
P8024Nobel Laureate API ID751
P856official websitehttp://web.mit.edu/horvitz/www/
P7305Online PWN Encyclopedia ID3912800
P496ORCID iD0000-0002-9964-9613
P7293PLWABN ID9810584610205606
P8349Proleksis enciklopedija ID2218
P1153Scopus author ID7007006983
P906SELIBR ID240043
P4342Store norske leksikon IDHoward_Robert_Horvitz
P214VIAF ID29510812
P7666Visuotinė lietuvių enciklopedija IDhoward-robert-horvitz
P10832WorldCat Entities IDE39PBJv8KY9xtRty6Pv3rPbmVC

P512academic degreeDoctor of PhilosophyQ752297
P6424affiliation stringMIT - Department of Biology
P166award receivedNobel Prize in Physiology or MedicineQ80061
March of Dimes Prize in Developmental BiologyQ175384
Paul Ehrlich and Ludwig Darmstaedter PrizeQ458338
Gruber Prize in GeneticsQ477467
Louisa Gross Horwitz PrizeQ899039
Grand Prix Charles-Leopold MayerQ904645
Alfred P. Sloan, Jr. PrizeQ964506
NAS Award in Molecular BiologyQ975308
Genetics Society of America MedalQ980337
Canada Gairdner International AwardQ1031994
Rosenstiel AwardQ1577949
Wiley PrizeQ2571006
W. Alden Spencer AwardQ7945315
Novartis-Drew AwardQ5119206
Harvard Centennial MedalQ5676302
Foreign Member of the Royal SocietyQ14906020
Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience ResearchQ30123933
Hans Sigrist PrizeQ30127637
Fellow of the American Academy of Arts and SciencesQ52382875
honorary doctor of the University of MiamiQ110471679
Mendel MedalQ63638576
P27country of citizenshipUnited States of AmericaQ30
P1343described by sourceEncyclopædia BritannicaQ455
MedvikQ99413897
P1889different fromRobert HorvitzQ112376927
P184doctoral advisorJames D. WatsonQ83333
Walter GilbertQ217486
Sydney BrennerQ234463
P185doctoral studentGary RuvkunQ504021
Victor AmbrosQ983858
Cornelia BargmannQ5042508
Junying YuanQ15893961
Barbara ConradtQ21255101
Ronald EllisQ41529107
Michael R. KoelleQ42356909
Andrew ChisholmQ42602483
Gillian M StanfieldQ46713857
Joshua M KaplanQ88008569
Peter W ReddienQ88073376
Gian GarrigaQ88397797
Melissa M HarrisonQ89694778
Paul W. SternbergQ55778919
Yi-Chun WuQ56481269
Erik C AndersenQ57159442
Matthias C TruttmannQ57329979
Niels RingstadQ57339778
Erik JørgensenQ57413029
Scott G. ClarkQ57714197
Dengke K MaQ61089107
Joshua LevinQ67487196
Shunji NakanoQ77373092
Yishi JinQ78210842
Iva Susan GreenwaldQ85940999
Shai ShahamQ87419436
P69educated atHarvard UniversityQ13371
Massachusetts Institute of TechnologyQ49108
Massachusetts Institute of Technology School of ScienceQ6784300
Niles East High SchoolQ15262345
P108employerMassachusetts Institute of TechnologyQ49108
Howard Hughes Medical InstituteQ1512226
P2021Erdős number4
P172ethnic groupwhite peopleQ235155
P734family nameHorvitzQ1630278
HorvitzQ1630278
HorvitzQ1630278
P101field of workcell biologyQ7141
molecular biologyQ7202
developmental biologyQ213713
apoptotic processQ14599311
P735given nameHowardQ3595959
HowardQ3595959
RobertQ4927937
RobertQ4927937
P1412languages spoken, written or signedEnglishQ1860
P463member ofRoyal SocietyQ123885
National Academy of SciencesQ270794
American Academy of Arts and SciencesQ463303
National Academy of MedicineQ4352382
P106occupationphysicianQ39631
biologistQ864503
university teacherQ1622272
geneticistQ3126128
P1344participant inWorld Economic Forum Annual Meeting 2014Q114717230
P551residenceUnited States of AmericaQ30
P21sex or gendermaleQ6581097
P91sexual orientationheterosexualityQ1035954
P26spouseMartha Constantine-PatonQ6774368

Reverse relations

doctoral advisor (P184)
Q42602483Andrew Chisholm
Q21255101Barbara Conradt
Q5042508Cornelia Bargmann
Q61089107Dengke K Ma
Q57159442Erik C Andersen
Q57413029Erik Jørgensen
Q504021Gary Ruvkun
Q88397797Gian Garriga
Q46713857Gillian M Stanfield
Q85940999Iva Susan Greenwald
Q67487196Joshua Levin
Q88008569Joshua M Kaplan
Q15893961Junying Yuan
Q57329979Matthias C Truttmann
Q89694778Melissa M Harrison
Q42356909Michael R. Koelle
Q57339778Niels Ringstad
Q55778919Paul W. Sternberg
Q88073376Peter W Reddien
Q41529107Ronald Ellis
Q57714197Scott G. Clark
Q87419436Shai Shaham
Q77373092Shunji Nakano
Q983858Victor Ambros
Q56481269Yi-Chun Wu
Q78210842Yishi Jin

author (P50)
Q37998192"Joy of the worm".
Q342790873-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Q55177522A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.
Q45065055A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans
Q42025406A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant
Q36161991A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans
Q34649473A first insight into the molecular mechanisms of apoptosis
Q47068763A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons
Q47069318A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.
Q58477872A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia
Q33520198A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans
Q44833513A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling
Q33316428A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants
Q33954502A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans
Q40625715A uniform genetic nomenclature for the nematode Caenorhabditis elegans
Q41786814A visible allele of the muscle gene sup-10X of C. elegans
Q33436384Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans
Q47069554Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans
Q42692754Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.
Q35638842Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
Q47069492An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
Q37107003An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways
Q47069461An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor
Q35121211Axons degenerate in the absence of mitochondria in C. elegans
Q69364970Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase
Q27304973Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
Q27324230Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans
Q38356322C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development
Q46567733C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
Q47069185C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates
Q35878894C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability
Q47068907C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
Q34322094C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
Q29618334C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
Q29616437C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
Q24336487C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
Q33952266C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle
Q47069350CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
Q39749591CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
Q30510542CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans
Q47068839Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
Q44450082Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis
Q28299039Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
Q38567060Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33
Q33955219Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying
Q46113273Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles.
Q59067261Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction
Q36764398Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans
Q42155894Cell interactions coordinate the development of the C. elegans egg-laying system
Q37843934Chemosensory cell function in the behavior and development of Caenorhabditis elegans
Q33239290Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans
Q46477072Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability
Q27340320Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex
Q60716053Chronic bleeding secondary to an unresectable duodenal adenocarcinoma controlled with sucralfate and famotidine
Q44183240Control by bacteriophage T4 of two sequential phosphorylations of the alpha subunit of Escherichia coli RNA polymerase
Q48110372Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
Q70121859Control of larval development by chemosensory neurons in Caenorhabditis elegans
Q47069020Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
Q41680627Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein
Q46474852Correction: Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans.
Q37671643Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans
Q35757652DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans
Q52535811Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.
Q40514184Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization
Q70993637Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities
Q44279919Dinucleotide repeat polymorphisms (D21S223 and D21S224) at 21q22.1
Q35987554Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans
Q42957894Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans.
Q31066332Dopamine signaling is essential for precise rates of locomotion by C. elegans
Q42579625EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans
Q28272431EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
Q52449851Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.
Q33949428Egg-laying defective mutants of the nematode Caenorhabditis elegans
Q28303406Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis
Q34236310FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans
Q74300098Fate of the nuclear lamina during Caenorhabditis elegans apoptosis
Q34604972Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase
Q45264157Gene linkage in familial amyotrophic lateral sclerosis: a progress report.
Q35241035Genes involved in two Caenorhabditis elegans cell-signaling pathways
Q42468230Genes necessary for directed axonal elongation or fasciculation in C. elegans
Q47069025Genes required for GABA function in Caenorhabditis elegans
Q33958436Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
Q64996881Genetic Control of Programmed Cell Death in C. Elegans.
Q72802873Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21
Q39586304Genetic control of Caenorhabditis elegans cell lineage
Q47069195Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
Q34196702Genetic control of programmed cell death in the nematode C. elegans.
Q54016389Genetic control of programmed cell death in the nematode Caenorhabditis elegans.
Q48123063Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers
Q40835187Genetics of programmed cell death in C. elegans: past, present and future.
Q42961179Genetics society of america program and abstracts.
Q70941967Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage
Q52272168Heterochronic mutants of the nematode Caenorhabditis elegans.
Q56535212Hypoxia-inducible factor cell non-autonomously regulates stress responses and behavior via a nuclear receptor
Q36530509IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway
Q33950952Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans
Q33971515Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans
Q34895771Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development
Q42673100Identification of three novel mutations in the gene for Cu/Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis
Q33905231Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis
Q48082210Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis
Q35567487In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans
Q38291375Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
Q34283104Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans
Q35512446LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans
Q35844907LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes
Q42399248Ligand-gated chloride channels are receptors for biogenic amines in C. elegans
Q35534485Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons
Q73031723Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22
Q38254339MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans
Q40839397MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
Q30493862Many families of C. elegans microRNAs are not essential for development or viability
Q52682512Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans.
Q28261655Mechanisms and Functions of Cell Death
Q36749996Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
Q28507645Members of the miRNA-200 family regulate olfactory neurogenesis
Q28253126MicroRNA expression in zebrafish embryonic development
Q28032481MicroRNA expression profiles classify human cancers
Q21092878Microarray analysis of microRNA expression in the developing mammalian brain
Q46532458Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins
Q34461607Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
Q21563452Most Caenorhabditis elegans microRNAs are individually not essential for development or viability
Q52236554Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.
Q36837043Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates
Q34608399Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.
Q36328437Mutations in synaptojanin disrupt synaptic vesicle recycling
Q27348703Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo
Q30999262Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine.
Q28236796Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
Q34250181Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans
Q28270636Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis
Q44883331Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans
Q34282331Mutations that lead to reiterations in the cell lineages of C. elegans
Q74581602Mutations that perturb vulval invagination in C. elegans
Q33952261Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans
Q40442315NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis
Q37046214Nematode postembryonic cell lineages.
Q70379907Neurone differentiation in cell lineage mutants of Caenorhabditis elegans
Q34617669New Genes That Interact With lin-35 Rb to Negatively Regulate the let-60 ras Pathway in Caenorhabditis elegans
Q58190028No association ofDYNC1H1with sporadic ALS in a case‐control study of a northern European derived population: A tagging SNP approach
Q48350282Nobel lecture. Worms, life and death.
Q34605661Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.
Q47069339Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.
Q30350701Obituary: Stanley J. Korsmeyer (1950-2005).
Q36766643Odorant-selective genes and neurons mediate olfaction in C. elegans.
Q34290559Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.
Q47069525PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans.
Q28304067Pattern formation during vulval development in C. elegans
Q48070743Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3.
Q47069455Phagocytosis promotes programmed cell death in C. elegans
Q35792598Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans
Q41075568Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro
Q69286428Polypeptide Bound to the Host RNA Polymerase is Specified by T4 Control Gene 33
Q29547748Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
Q70479333Postembryonic nongonadal cell lineages of the nematode Panagrellus redivivus: description and comparison with those of Caenorhabditis elegans
Q41477059Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans
Q57939597Programmed cell death in Caenorhabditis elegans
Q36157242Programmed elimination of cells by caspase-independent cell extrusion in C. elegans
Q34472107Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans
Q30528880Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans
Q28943310Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
Q28296399Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33
Q27932881Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.
Q112717509Replication stress promotes cell elimination by extrusion
Q35791458Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans
Q34524707SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function
Q34550044SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans
Q35037849SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose
Q71603559Serotonin and octopamine in the nematode Caenorhabditis elegans
Q36471871Signal transduction during C. elegans vulval induction
Q34100473Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans
Q35130721Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex
Q33990403Studies of mutations in T4 control genes 33 and 55
Q72169651Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis
Q37483933Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure
Q27861103The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Q28204737The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway
Q47068900The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
Q28256420The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
Q33876675The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein
Q42650881The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors
Q47950933The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway
Q47069049The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
Q47069338The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein
Q34266474The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO
Q36151083The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.
Q28272159The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
Q46412377The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage
Q37493976The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome
Q47068783The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates.
Q48062874The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.
Q34214723The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
Q47068684The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
Q48068478The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway
Q43696096The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates
Q47069050The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein
Q47068876The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor
Q47069175The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions
Q72189612The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK
Q27332402The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing
Q48061840The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein
Q42536961The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.
Q24312342The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation
Q34306496The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
Q40671009The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase
Q35105757The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.
Q33963399The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins
Q34047933The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
Q27335341The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF
Q33961013The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions.
Q30982840The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction.
Q34392836The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated
Q39890232The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior
Q36765041The GABAergic nervous system of Caenorhabditis elegans
Q37608546The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain
Q34714971The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination
Q24540364The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development
Q38321297The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene
Q33908341The ced-8 gene controls the timing of programmed cell deaths in C. elegans.
Q46563375The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans
Q35912786The engulfment process of programmed cell death in caenorhabditis elegans
Q40201354The genetic control of cell lineage during nematode development
Q40431225The genetics of programmed cell death in the nematode Caenorhabditis elegans.
Q40585908The ins and outs of programmed cell death during C. elegans development
Q28609145The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
Q28270307The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans
Q41701405The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
Q34264575The lin-12 locus specifies cell fates in Caenorhabditis elegans
Q28302778The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events
Q28140045The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
Q42961253The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.
Q35020039The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
Q28611298The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
Q27314756The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans
Q47069113Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.
Q42964179Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9.
Q48897272Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis.
Q22008748Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway
Q34388176Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.
Q47069246Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death
Q47069598Two C. elegans genes control the programmed deaths of specific cells in the pharynx
Q47069021Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development
Q48151994Two independent dinucleotide repeat polymorphisms at the D21S235 locus (21q22.1)
Q42654395Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system
Q22010144UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development
Q45939572US immigration order strikes against biotech.
Q37090072Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
Q41499175Wnt and EGF pathways act together to induce C. elegans male hook development
Q48235550Worms, life, and death (Nobel lecture).
Q24307778Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells
Q35200613clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
Q43681650dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development
Q45943348lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions.
Q40983720lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Q34589802lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein
Q34941722sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination
Q47069194unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration
Q33994593unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype

winner (P1346)
Q964506Alfred P. Sloan, Jr. Prize
Q30123933Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research
Q899039Louisa Gross Horwitz Prize
Q975308NAS Award in Molecular Biology
Q458338Paul Ehrlich and Ludwig Darmstaedter Prize

Q83333James D. Watsondoctoral studentP185
Q6774368Martha Constantine-PatonspouseP26
Q112376927Robert Horvitzdifferent fromP1889

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