Drug penetration in solid tumours (scientific article (publication date: August 2006))

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Q92551431	Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment
Q36203093	Folic acid-conjugated soybean protein-based nanoparticles mediate efficient antitumor ability in vitro
Q37792592	Forcing form and function: biomechanical regulation of tumor evolution
Q94528700	Frontiers in Intravital Multiphoton Microscopy of Cancer
Q33746335	Frontiers in cancer nanomedicine: directing mass transport through biological barriers
Q57812848	Functional Nanoparticles for Tumor Penetration of Therapeutics
Q90331929	Functionalization of Cellulose Nanocrystals with PEG-Metal-Chelating Block Copolymers via Controlled Conjugation in Aqueous Media
Q58802900	Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core
Q48243945	Functionalized Nanoparticles Efficiently Enhancing the Targeted Delivery, Tumor Penetration, and Anticancer Activity of 7-Ethyl-10-Hydroxycamptothecin.
Q61804215	GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models
Q39694952	Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.
Q39511773	Gene therapy for lung cancer malignant pleural effusion: current and future nano-biotechnology
Q28548481	Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing
Q29248638	Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer
Q39255510	Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models
Q38244345	Glioma stem cells: markers, hallmarks and therapeutic targeting by metformin
Q36249040	HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter
Q33711448	Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration
Q37091887	Hedgehog signaling in prostate cancer and its therapeutic implication
Q37522770	Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging
Q58698483	Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment
Q41276800	Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors
Q37352425	High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy
Q50032174	High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer
Q48699259	Highly fluorescent, photostable, and ultrasmall silicon drug nanocarriers for long-term tumor cell tracking and in-vivo cancer therapy
Q36125886	Hydrogel Microwell Arrays Allow the Assessment of Protease-Associated Enhancement of Cancer Cell Aggregation and Survival.
Q55421651	Hydrogel microenvironments for cancer spheroid growth and drug screening.
Q64973993	Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells.
Q48347605	Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery
Q47762085	Hyperthermia-enhanced targeted drug delivery using magnetic resonance-guided focussed ultrasound: a pre-clinical study in a genetic model of pancreatic cancer.
Q39604676	Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs
Q41467964	Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models.
Q37084096	Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.
Q37418248	Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors
Q37730085	Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
Q38051286	Hypoxia-inducible factors as key regulators of tumor inflammation
Q61799902	Hypoxia-targeted drug delivery
Q38824983	Hypoxic tumor microenvironment: Opportunities to develop targeted therapies.
Q50003353	Identification of Staphylococcus aureus α-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells
Q90177176	Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment
Q38228652	Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles
Q33576048	Image-guided local delivery strategies enhance therapeutic nanoparticle uptake in solid tumors
Q36053235	Imaging Intratumoral Nanoparticle Uptake After Combining Nanoembolization with Various Ablative Therapies in Hepatic VX2 Rabbit Tumors.
Q38213988	Imaging hallmarks of cancer in living mice
Q35995175	Imaging mass spectrometry for the precise design of antibody-drug conjugates.
Q35903509	Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance
Q50190180	Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids
Q26781538	Immunotherapy for pancreatic ductal adenocarcinoma: an overview of clinical trials
Q37683464	Impact of Pressurized Intraperitoneal Aerosol Chemotherapy on Quality of Life and Symptoms in Patients with Peritoneal Carcinomatosis: A Retrospective Cohort Study
Q92129920	Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models
Q28543432	Impediments to enhancement of CPT-11 anticancer activity by E. coli directed beta-glucuronidase therapy
Q35699612	Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance
Q35712194	Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA.
Q36971132	Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT).
Q35101117	Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging
Q39324948	Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging.
Q34508475	Improved tumor vascular function following high-dose epidermal growth factor receptor tyrosine kinase inhibitor therapy
Q37381491	Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing.
Q27300853	Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization
Q64991848	Improving Payload Capacity and Anti-Tumor Efficacy of Mesenchymal Stem Cells Using TAT Peptide Functionalized Polymeric Nanoparticles.
Q34145464	Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan
Q37137443	In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma
Q37492164	In Vivo Feasibility of Electrostatic Precipitation as an Adjunct to Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC).
Q35053318	In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis
Q38990370	In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
Q89537182	In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer
Q33605281	In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer
Q39340648	In vivo controlled release and prolonged antitumor effects of 2-methoxyestradiol solid lipid nanoparticles incorporated into a thermosensitive hydrogel
Q53306641	In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels.
Q36568954	In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters
Q34133018	In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles
Q33560776	Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor
Q37845642	Influence of stress on extracellular matrix and integrin biology.
Q36262935	Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors
Q38012447	Inhaled chemotherapy in lung cancer: future concept of nanomedicine
Q64287480	Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis
Q29547558	Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
Q58214998	Inhibition of Radiation and Temozolomide-Induced Invadopodia Activity in Glioma Cells Using FDA-Approved Drugs
Q37246054	Inhibition of Rho-Associated Kinase 1/2 Attenuates Tumor Growth in Murine Gastric Cancer
Q99248250	Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma
Q90633526	Inhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma
Q35005290	Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.
Q36840074	Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
Q83389944	Integrating pharmacogenetics into gemcitabine dosing--time for a change?
Q27025653	Integrative models of vascular remodeling during tumor growth
Q50034069	Interleukin-2: Old and New Approaches to Enhance Immune-Therapeutic Efficacy
Q27310300	Interstitial fluid flow and drug delivery in vascularized tumors: a computational model
Q91811755	Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy
Q36366424	Intracellular-signaling tumor-regression modeling of the pro-apoptotic receptor agonists dulanermin and conatumumab
Q37594150	Intraperitoneal chemotherapy of peritoneal carcinomatosis using pressurized aerosol as an alternative to liquid solution: first evidence for efficacy.
Q49118164	Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence
Q38211694	Intratumor heterogeneity and its impact on drug distribution and sensitivity
Q35091415	Intratumoral drug delivery with nanoparticulate carriers
Q38662882	Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses
Q50010466	Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Q27319974	Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields
Q51833938	Intrinsic and induced drug resistance mechanisms: in silico investigations at the cellular and tissue scales.
Q27300805	Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia
Q35890731	Iontophoresis Improved Growth Reduction of Invasive Squamous Cell Carcinoma in Topical Photodynamic Therapy.
Q37479772	Iron chelators target both proliferating and quiescent cancer cells.
Q36952188	Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapy
Q42860816	Is nano too big?
Q33838696	Isolated system towards a successful radiotherapy treatment
Q47197354	Junction opener protein increases nanoparticle accumulation in solid tumors
Q41113421	Kanglaite inhibits the expression of drug resistance genes through suppressing PVT1 in cisplatin-resistant gastric cancer cells
Q89551966	Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome
Q39032035	King cobra (Ophiophagus hannah) venom L-amino acid oxidase induces apoptosis in PC-3 cells and suppresses PC-3 solid tumor growth in a tumor xenograft mouse model
Q51820438	Labile ruthenium(ii) complexes with extended phenyl-substituted terpyridyl ligands: synthesis, aquation and anticancer evaluation.
Q38590390	Layer-by-Layer Assemblies for Cancer Treatment and Diagnosis
Q38980782	Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment.
Q28553729	Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors
Q64996441	Limiting tumor seeding as a therapeutic approach for metastatic disease.
Q50004163	Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice
Q36217918	Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier.
Q36943978	Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma.
Q38759181	Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications
Q37107139	Liquid-based three-dimensional tumor models for cancer research and drug discovery
Q35983594	Local iontophoretic administration of cytotoxic therapies to solid tumors
Q89254122	Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft
Q34251745	Long-circulating 15 nm micelles based on amphiphilic 3-helix peptide-PEG conjugates
Q37300593	Long-term results of intraoperative electron beam radiation therapy for nonmetastatic locally advanced pancreatic cancer: Retrospective cohort study, 7-year experience with 247 patients at the National Cancer Center in China
Q92992671	Luminescent Probe Based Techniques for Hypoxia Imaging
Q47114407	MALDI mass spectrometry imaging of erlotinib administered in combination with bevacizumab in xenograft mice bearing B901L, EGFR-mutated NSCLC cells.
Q38946777	MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery
Q57179054	Macrophages as Drug Delivery Carriers for Acoustic Phase-Change Droplets
Q34130478	Macrophages homing to metastatic lymph nodes can be monitored with ultrasensitive ferromagnetic iron-oxide nanocubes and a 1.5T clinical MR scanner
Q38616007	Magnetic Resonance-Guided Drug Delivery
Q38129944	Magnetic resonance imaging of tumor oxygenation and metabolic profile
Q52626109	Magnetically assisted intraperitoneal drug delivery for cancer chemotherapy.
Q36741548	Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
Q92331037	Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer
Q36651667	Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors
Q26820859	Mass spectrometry imaging of therapeutics from animal models to three-dimensional cell cultures
Q40626318	Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors
Q57804227	Mathematical Modelling of a Hypoxia-regulated Oncolytic Virus Delivered by Tumour-associated Macrophages
Q38594401	Mathematical and computational models of drug transport in tumours.
Q38392523	Mathematical modeling analysis of intratumoral disposition of anticancer agents and drug delivery systems
Q27023583	Mathematical models of the steps involved in the systemic delivery of a chemotherapeutic to a solid tumor: From circulation to survival
Q36153295	Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice
Q27347800	Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells
Q34807025	Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment
Q42158682	Measurement of magnetic nanoparticle relaxation time
Q58132098	Mechanical Forces in Tumor Angiogenesis
Q33400987	Mechanics, malignancy, and metastasis: the force journey of a tumor cell
Q38947459	Mechanism of tumour vascularization in experimental lung metastases
Q33632105	Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response
Q37143641	Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements
Q44870836	Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location
Q39010041	Melanoma never says die.
Q37480184	Metastasis of ovarian cancer is mediated by kallikrein related peptidases
Q37593707	Methods for site-specific drug conjugation to antibodies
Q38871432	Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia
Q39324636	Metronomic chemotherapy in combination with antiangiogenic treatment induces mosaic vascular reduction and tumor growth inhibition in hepatocellular carcinoma xenografts
Q63547125	Microbubbles, Nanodroplets and Gas-Stabilizing Solid Particles for Ultrasound-Mediated Extravasation of Unencapsulated Drugs: An Exposure Parameter Optimization Study
Q39651338	Microcirculation of secondary bone tumors in vivo: The impact of minor surgery at a distal site
Q64997020	Microenvironment Cell Contribution to Lymphoma Immunity.
Q55424318	Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance.
Q37420604	Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance
Q36836602	Microenvironmental regulation of biomacromolecular therapies
Q37137850	Microfabricated polymeric vessel mimetics for 3-D cancer cell culture
Q37540653	Microfluidic 3D cell culture: potential application for tissue-based bioassays
Q35841479	Microfluidic device for recreating a tumor microenvironment in vitro
Q37141366	Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil
Q98907310	Microfluidics for interrogating live intact tissues
Q39415390	Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro.
Q47870424	Microscale Mass Spectrometry Analysis of Extracellular Metabolites in Live Multicellular Tumor Spheroids.
Q33879424	Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
Q36021883	Mini-pillar array for hydrogel-supported 3D culture and high-content histologic analysis of human tumor spheroids
Q33605145	Miniaturized pre-clinical cancer models as research and diagnostic tools
Q33599243	Modeling nasopharyngeal carcinoma in three dimensions
Q47653913	Modeling the Dynamics of Heterogeneity of Solid Tumors in Response to Chemotherapy.
Q89711398	Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma
Q50998666	Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors.
Q41248289	Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
Q92617950	Modelling drug transport during intraperitoneal chemotherapy
Q64963505	Modelling the transport of fluid through heterogeneous, whole tumours in silico.
Q56872060	Modular pore-forming immunotoxins with caged cytotoxicity tailored by directed evolution
Q35920685	Modulation of the tumor vasculature and oxygenation to improve therapy
Q53746575	Molecular and Pharmacological Mechanisms of Drug Resistance:An Evolving Paradigm.
Q30433423	Molecular imaging agents: impact on diagnosis and therapeutics in oncology
Q37367335	Molecular imaging and therapy of cancer with radiolabeled nanoparticles
Q33705108	Molecular mechanisms of hypoxia in cancer
Q42006859	Molecular pathways: involving microenvironment damage responses in cancer therapy resistance
Q38931516	Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging
Q37115798	Motility is critical for effective distribution and accumulation of bacteria in tumor tissue
Q38844101	Multi-modal magnetic resonance imaging and histology of vascular function in xenografts using macromolecular contrast agent hyperbranched polyglycerol (HPG-GdF).
Q57900919	Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney
Q33637214	Multicellular tumor spheroids as a model for assessing delivery of oligonucleotides in three dimensions
Q28486451	Multicellular tumor spheroids for evaluation of cytotoxicity and tumor growth inhibitory effects of nanomedicines in vitro: a comparison of docetaxel-loaded block copolymer micelles and Taxotere®
Q34241923	Multichannel imaging to quantify four classes of pharmacokinetic distribution in tumors
Q97422902	Multicolor fluorescence imaging using a single RGB-IR CMOS sensor for cancer detection with smURFP-labeled probiotics
Q41275697	Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation.
Q38848350	Multidrug resistance characterization in multicellular tumour spheroids from two human lung cancer cell lines.
Q39180827	Multifunctional albumin nanoparticles as combination drug carriers for intra-tumoral chemotherapy.
Q33894623	Multilayer spheroids to quantify drug uptake and diffusion in 3D.
Q58701299	Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
Q90177754	Multimodal Imaging of Amyloid Plaques: Fusion of the Single-Probe Mass Spectrometry Image and Fluorescence Microscopy Image
Q38517521	Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production
Q43226325	Multiscale kinetic modeling of liposomal Doxorubicin delivery quantifies the role of tumor and drug-specific parameters in local delivery to tumors
Q37263422	Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo
Q34572820	Multistage nanoparticle delivery system for deep penetration into tumor tissue
Q39901722	Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting
Q37600858	Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs
Q28740410	Multizone paper platform for 3D cell cultures
Q28078448	NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?
Q89103702	Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro
Q37798870	Nano to micro delivery systems: targeting angiogenesis in brain tumors
Q47121798	Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy
Q38128317	Nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma.
Q37564547	Nanodiamonds as vehicles for systemic and localized drug delivery
Q37857064	Nanomaterials: applications in cancer imaging and therapy.
Q38794563	Nanomedicine strategies for sustained, controlled and targeted treatment of cancer stem cells
Q33759991	Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence
Q36901928	Nanoparticle characterization: state of the art, challenges, and emerging technologies.
Q38131264	Nanopreparations to overcome multidrug resistance in cancer
Q91669651	Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) Enhances Intratumoral Transport of Nanomedicine
Q39255968	Nanoscale Biodegradable Organic-Inorganic Hybrids for Efficient Cell Penetration and Drug Delivery
Q36953404	Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer
Q36803827	Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities
Q35264028	Nanotechnology for energy-based cancer therapies
Q37686905	Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody
Q38701056	Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody
Q26746714	Neural regulation of cancer: from mechanobiology to inflammation
Q37344283	Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.
Q37396577	Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies
Q92874852	New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment
Q38645930	New therapeutic directions for advanced pancreatic cancer: cell cycle inhibitors, stromal modifiers and conjugated therapies
Q47144801	Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration
Q43733105	Non-nuclear localization of Ki-67 in human colorectal cancer cells grown as multicellular layers
Q33877554	Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue
Q38953677	Nonvascular drug-eluting stent coated with sodium caprate-incorporated polyurethane for the efficient penetration of paclitaxel into tumor tissue
Q39288497	Novel Insights into the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors
Q30466993	Novel Methods of Enhanced Retention in and Rapid, Targeted Release from Liposomes
Q46756188	Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel.
Q22000766	Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors
Q47117973	Novel peptide probes to assess the tensional state of fibronectin fibers in cancer
Q38114865	OCTN cation transporters in health and disease: role as drug targets and assay development
Q41953532	On-chip clearing of arrays of 3-D cell cultures and micro-tissues.
Q42046479	On-chip three-dimensional tumor spheroid formation and pump-less perfusion culture using gravity-driven cell aggregation and balanced droplet dispensing
Q38848223	Oncolytic Immunotherapy for Treatment of Cancer
Q38033591	Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets
Q36769180	Oncolytic viruses in cancer therapy
Q37926486	Oncolytic viruses: do they have a role in anti-cancer therapy?
Q51081589	One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance.
Q44348324	Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models.
Q26826863	Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Q92617961	Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model
Q37695345	Optimizing non-invasive radiofrequency hyperthermia treatment for improving drug delivery in 4T1 mouse breast cancer model
Q26801834	Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer: Normalization, Not Destruction
Q38703668	Ovarian cancer spheroid shrinkage following continuous exposure to cisplatin is a function of spheroid diameter
Q92255092	Overcoming Drug Resistance by Taking Advantage of Physical Principles: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Q36454792	Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors
Q53739678	Overcoming the tumor microenvironment: the role of nanohyperthermia.
Q38915770	Overexpression of CDX2 in gastric cancer cells promotes the development of multidrug resistance
Q35481434	Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistance
Q49804818	Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments.
Q40975802	Overexpression of the human antigen R suppresses the immediate paradoxical proliferation of melanoma cell subpopulations in response to suboptimal BRAF inhibition
Q42730647	Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases
Q26799981	Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid
Q91897152	Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy
Q60930267	P-glycoprotein-targeted photodynamic therapy boosts cancer nanomedicine by priming tumor microenvironment
Q42114642	PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses
Q34602948	Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment
Q33793966	Pancreatic adenocarcinoma response to chemotherapy enhanced with non-invasive radio frequency evaluated via an integrated experimental/computational approach.
Q35008942	Paper-supported 3D cell culture for tissue-based bioassays
Q47794249	Particle Targeting in Complex Biological Media
Q49628457	Particle morphology: an important factor affecting drug delivery by nanocarriers into solid tumors.
Q26752406	Pathophysiological Basis for the Formation of the Tumor Microenvironment
Q46044942	Pectin nanoparticle enhances cytotoxicity of methotrexate against HepG2 cells
Q35135650	Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
Q91857309	Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin
Q34294361	Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib
Q40578734	Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticles
Q52646682	Peptide Mediated In Vivo Tumor Targeting of Nanoparticles through Optimization in Single and Multilayer In Vitro Cell Models.
Q56889662	Peptides as drug delivery vehicles across biological barriers
Q27024850	Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery
Q52722299	Peri-tumor administration of 5-fluorouracil sol-gel using a hollow microneedle for treatment of gastric cancer.
Q47661007	Pharmacokinetic Considerations for Antibody-Drug Conjugates against Cancer.
Q43247519	Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy.
Q26752368	Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective
Q43147021	Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumors
Q33719284	Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression
Q46346802	Photocatalytic interaction of aminophylline-riboflavin leads to ROS-mediated DNA damage and cell death: A novel phototherapeutic mechanism for cancer
Q47301657	Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery.
Q37340860	Photoswitchable nanoparticles for in vivo cancer chemotherapy
Q84534127	Physical determinants of vascular network remodeling during tumor growth
Q34039413	Physicochemical properties of epidermal growth factor receptor inhibitors and development of a nanoliposomal formulation of gefitinib
Q34275537	Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
Q55515912	Physiological random processes in precision cancer therapy.
Q38248809	Plasma and cellular pharmacokinetic considerations for the development and optimization of antitumor block copolymer micelles
Q37262478	Platform for high-throughput testing of the effect of soluble compounds on 3D cell cultures
Q28085664	Polymer nanostructures synthesized by controlled living polymerization for tumor-targeted drug delivery
Q30372383	Polymeric Nanostructures for Imaging and Therapy
Q37739481	Polymeric drug delivery systems for localized cancer chemotherapy
Q36225509	Polymers for drug delivery systems
Q35579375	Potent and tumor specific: arming bacteria with therapeutic proteins
Q39525005	Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study
Q90236822	Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
Q52576799	Precision Medicine with Imprecise Therapy: Computational Modeling for Chemotherapy in Breast Cancer.
Q46013875	Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.
Q37816960	Preclinical development of molecular-targeted agents for cancer
Q35651085	Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin
Q38769753	Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin
Q37433585	Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation
Q38086778	Prediction of drug disposition on the basis of its chemical structure
Q28548074	Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma
Q36951951	Predictive models of diffusive nanoparticle transport in 3-dimensional tumor cell spheroids
Q91530150	Preparation of iron oxide mesoporous magnetic microparticles as novel multidrug carriers for synergistic anticancer therapy and deep tumor penetration
Q91572974	Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications
Q60955232	Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Gastric Cancer Patients with Peritoneal Metastasis (PM): Results of a Single-Center Experience and Register Study
Q27313250	Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with Low-Dose Cisplatin and Doxorubicin in Gastric Peritoneal Metastasis.
Q41822485	Pressurized intraperitoneal aerosol chemotherapy (PIPAC): occupational health and safety aspects.
Q61810585	Pressurized intraperitoneal aerosol chemotherapy procedure for nonresectable peritoneal carcinomatosis: First Indian study
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Q38168926	Prior exposure to chemotherapy: a marker of sensitivity and selection for antiangiogenic therapy in breast cancer?
Q37002730	Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
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Q35689902	Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy--the SpheroNEO study
Q36985913	Prospects and challenges of the development of lipoprotein-based formulations for anti-cancer drugs
Q47885456	Protein nanocages that penetrate airway mucus and tumor tissue
Q35070612	Protein transfection study using multicellular tumor spheroids of human hepatoma Huh-7 cells
Q42873690	Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics
Q39306543	Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities
Q30472417	Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids
Q30426788	Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors
Q91522252	Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1
Q90749231	Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models
Q34257226	Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Q35786026	Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results.
Q42275555	Quantitating drug-target engagement in single cells in vitro and in vivo
Q28547003	Quantitative Analysis of the Enhanced Permeation and Retention (EPR) Effect
Q92134774	Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib in Liver Metastases of Gastrointestinal Stromal Tumors
Q92927816	Quantitative Size-Based Analysis of Tumor Spheroids and Responses to Therapeutics
Q35181116	Quantitative determination of irinotecan and the metabolite SN-38 by nanoflow liquid chromatography-tandem mass spectrometry in different regions of multicellular tumor spheroids
Q90416601	Quantitative imaging of receptor-ligand engagement in intact live animals
Q44812154	Quantitative synchrotron X-ray fluorescence study of the penetration of transferrin-conjugated gold nanoparticles inside model tumour tissues
Q42799162	RGD-Modified Albumin Nanoconjugates for Targeted Delivery of a Porphyrin Photosensitizer.
Q37437680	Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody.
Q36938779	Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer
Q92618082	Randomized control trial comparing quality of life of patients with end-stage peritoneal metastasis treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC) and intravenous chemotherapy
Q36001035	Rapid Light-Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin-Phospholipids
Q35479808	Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy
Q48201946	Ratiometric in vivo auditioning of targeted silver nanoparticles
Q38987861	Real-time cell cycle imaging during melanoma growth, invasion, and drug response.
Q27306235	Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery
Q90398514	Recellularized Colorectal Cancer Patient-derived Scaffolds as in vitro Pre-clinical 3D Model for Drug Screening
Q37997512	Recent advances in drug delivery strategies for treatment of ovarian cancer
Q38179351	Regional chemotherapy of the lung: transpulmonary chemoembolization in malignant lung tumors
Q36909380	Renal and hepatic toxicities after pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Q62738057	Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction
Q90458713	Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture
Q35852614	Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp.
Q54343338	Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro.
Q42640884	Rethinking cancer nanotheranostics
Q37009280	Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation
Q39095784	Reversal of multidrug resistance in gastric cancer cells by E2F-1 downregulation in vitro and in vivo
Q30485754	Reversibility of apoptosis in cancer cells
Q28477221	Reversion of pH-induced physiological drug resistance: a novel function of copolymeric nanoparticles
Q33433283	Revisiting perioperative chemotherapy: the critical importance of targeting residual cancer prior to wound healing
Q35970782	Robotic production of cancer cell spheroids with an aqueous two-phase system for drug testing
Q33557865	Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing
Q40182201	SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53.
Q89638520	SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Q37651101	SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin
Q37347529	SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions
Q35880493	Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
Q28603646	Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma
Q34626314	Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses
Q30447871	Shedding light on nanomedicine.
Q58570176	Short duration cancer treatment: inspired by a fast bio-resorbable smart nano-fiber device containing NIR lethal polydopamine nanospheres for effective chemo-photothermal cancer therapy
Q40147264	Sickle cells produce functional immune modulators and cytotoxics
Q27324518	Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response
Q35051630	Significance of c-MET overexpression in cytotoxic anticancer drug-resistant small-cell lung cancer cells
Q39227476	Silicon-nanowire-based nanocarriers with ultrahigh drug-loading capacity for in vitro and in vivo cancer therapy
Q39839745	Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation
Q30607882	Single particle tracking reveals biphasic transport during nanorod magnetophoresis through extracellular matrix
Q59465667	Size-Dependent Gold Nanoparticle Interaction at Nano-Micro Interface Using Both Monolayer and Multilayer (Tissue-Like) Cell Models
Q89985210	Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
Q36017657	Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo
Q36971700	Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates
Q90212229	Small-Format Drug Conjugates: A Viable Alternative to ADCs for Solid Tumours?
Q38221776	Smart chemistry in polymeric nanomedicine.
Q28817755	Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers
Q30406257	Sonochemotherapy: from bench to bedside
Q52591101	Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability.
Q38612541	Sonoporation: Applications for Cancer Therapy
Q28544732	Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy
Q89638584	Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment
Q33952918	Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness
Q35745894	Spatio-Temporal Dynamics of Hypoxia during Radiotherapy
Q36056035	Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics
Q30368021	Spatiotemporal drug delivery using laser-generated-focused ultrasound system.
Q30052394	Spheroid-based drug screen: considerations and practical approach
Q37311025	Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin
Q33607808	Spheroids of HER2-Positive Breast Adenocarcinoma for Studying Anticancer Immunotoxins In Vitro
Q26852097	State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
Q33995719	Strategies for advancing cancer nanomedicine
Q38776676	Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy
Q37037950	Strategies to advance translational research into brain barriers
Q33815414	Stromal regulation of vessel stability by MMP14 and TGFbeta
Q37945297	Structural adaptation of normal and tumour vascular networks.
Q35049224	Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles
Q97425810	Studies of nanoparticle delivery with in vitro bio-engineered microtissues
Q30457441	Study of the UTMD-based delivery system to induce cervical cancer cell apoptosis and inhibit proliferation with shRNA targeting Survivin
Q35868868	Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors
Q39829826	Supramolecular Hydrogel from Nanoparticles and Cyclodextrins for Local and Sustained Nanoparticle Delivery
Q48188592	Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids.
Q36456892	Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids
Q64098755	Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers
Q38228362	Surfactant-based drug delivery systems for treating drug-resistant lung cancer
Q49023233	Sustained delivery of vincristine inside an orthotopic mouse sarcoma model decreases tumor growth
Q34676773	Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer
Q34040411	Synthesis and biological evaluation of water-soluble progesterone-conjugated probes for magnetic resonance imaging of hormone related cancers
Q33358222	Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells
Q28072904	Synthetic lethality in lung cancer and translation to clinical therapies
Q35565769	Synthetic tumor networks for screening drug delivery systems
Q33591632	TGF-β-independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC
Q37700855	TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.
Q33784625	TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
Q39250458	Tailored immunoconjugate therapy depending on a quantity of tumor stroma
Q55210424	Target-specific delivery of oxaliplatin to HER2-positive gastric cancer cells in vivo using oxaliplatin-au-fe3o4-herceptin nanoparticles.
Q28069354	Targeted Cancer Therapy Using Engineered Salmonella typhimurium
Q37220415	Targeted Cancer Therapy with Tumor Necrosis Factor-Alpha
Q61797466	Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency
Q28533782	Targeted drug delivery systems mediated by a novel Peptide in breast cancer therapy and imaging
Q37580230	Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment.
Q37010760	Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis
Q36786792	Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4
Q50890602	Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds.
Q52684332	Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling.
Q64274340	Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis
Q89761369	Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis
Q35845149	Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Q49167162	Targeting Pancreatic Cancer Cell Plasticity: The Latest in Therapeutics
Q54438434	Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells.
Q91565659	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
Q38927345	Targeting and microenvironment-responsive lipid nanocarrier for the enhancement of tumor cell recognition and therapeutic efficiency
Q50863499	Targeting curcumin to specific tumour cell environments: the influence of ancillary ligands.
Q29615491	Targeting hypoxia in cancer therapy
Q41656018	Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model.
Q38500320	Targeting of cancer stem cells by inhibitors of DNA and histone methylation.
Q37693328	Targeting of crosstalk between tumor and tumor microenvironment by β-D mannuronic acid (M2000) in murine breast cancer model.
Q33591876	Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies
Q38259982	Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference
Q26774750	Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
Q51746852	Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.
Q38880513	Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look
Q38230869	Targeting tumor microenvironment: crossing tumor interstitial fluid by multifunctional nanomedicines
Q38263008	Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Q52769266	The Continued Promise and Many Disappointments of Oncolytic Virotherapy in Gastrointestinal Malignancies.
Q37236019	The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs
Q51769661	The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.
Q38999221	The Role of Interventional Oncology in the Management of Lung Cancer.
Q26801843	The Role of Stroma in Tumor Development
Q38980088	The Tumor Microenvironment as a Barrier to Cancer Nanotherapy
Q41272286	The Volume of Three-Dimensional Cultures of Cancer Cells InVitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors
Q88809961	The challenge of drug resistance in cancer treatment: a current overview
Q27314606	The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy
Q39400527	The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials
Q39408049	The distribution and retention of paclitaxel and doxorubicin in multicellular layer cultures
Q33595085	The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors
Q98303485	The dose threshold for nanoparticle tumour delivery
Q38206349	The drug discovery by nanomedicine and its clinical experience
Q35946514	The dynamics of drug resistance: a mathematical perspective
Q34615075	The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors.
Q41828751	The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems
Q82676939	The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery
Q33289164	The effect of the histological properties of tumors on transfection efficiency of electrically assisted gene delivery to solid tumors in mice
Q33514437	The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma
Q36116601	The engineered Salmonella typhimurium inhibits tumorigenesis in advanced glioma
Q41678839	The impact of hypoxia on tumor-associated macrophages
Q38028791	The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies
Q38437281	The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.
Q89747982	The kinase polypharmacology landscape of clinical PARP inhibitors
Q37578813	The miR-106b~25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300.
Q35125060	The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
Q38816759	The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability
Q48193643	The renaissance of anti-neoplastic immunity from tumor cell demise
Q35862359	The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer
Q37403035	The reversal of drug-resistance in tumors using a drug-carrying nanoparticular system
Q38084705	The role of cell cycle in the efficiency and activity of cancer nanomedicines
Q50539312	The role of the microvascular network structure on diffusion and consumption of anticancer drugs.
Q36833440	The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study
Q28384148	The tumor microenvironment and strategies to improve drug distribution
Q39303258	The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models
Q28550211	Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill
Q43229406	Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes
Q42360479	Therapeutic properties of aerobic training after a cancer diagnosis: more than a one-trick pony?
Q37785480	Therapeutic targeting of the prostate cancer microenvironment
Q91143110	Therapy resistance beyond cellular dormancy
Q58762564	Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
Q38862089	Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs.
Q38724273	Three-dimensional cell culture models for anticancer drug screening: Worth the effort?
Q34225333	Three-dimensional in vitro tumor models for cancer research and drug evaluation.
Q38812773	Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.
Q46979399	Time-course-dependent microvascular alterations in a model of myeloid leukemia in vivo
Q36216452	Time-dependent pretreatment with bevacuzimab increases tumor specific uptake of cetuximab in preclinical oral cavity cancer studies.
Q27304804	Tissue distribution and efficacy of gold nanorods coupled with laser induced photoplasmonic therapy in ehrlich carcinoma solid tumor model
Q64122281	Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells
Q42358894	Toward Localized In Vivo Biomarker Concentration Measurements
Q39461289	Toward a 3D cellular model for studying in vitro the outcome of photodynamic treatments: accounting for the effects of tissue complexity.
Q41814813	Towards an integrated systems-based modelling framework for drug transport and its effect on tumour cells
Q59793133	Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework
Q53536921	Towards solid tumor treatment by irreversible electroporation: intrinsic redistribution of fields and currents in tissue.
Q27335464	Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations
Q91529633	Transcellular transfer of nanomedicine
Q59060386	Translating cancer research into targeted therapeutics
Q38950411	Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept
Q50082408	Transport of drugs from blood vessels to tumour tissue.
Q58595670	Transvenous pulmonary chemoembolization (TPCE) for palliative or neoadjuvant treatment of lung metastases
Q55318427	Treatment of patients with peritoneal metastases from gastric cancer.
Q35020097	Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating
Q57345703	Triggered Drug Release and Enhanced Drug Transport from Ultrasound-Responsive Nanoparticles
Q38155500	Triggered Nanoparticles as Therapeutics.
Q36326953	Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution
Q90633042	Tumor Drug Distribution after Local Drug Delivery by Hyperthermia, In Vivo
Q92295351	Tumor Priming by SMO Inhibition Enhances Antibody Delivery and Efficacy in a Pancreatic Ductal Adenocarcinoma Model
Q51846287	Tumor Restrictions to Oncolytic Virus.
Q28818440	Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy
Q34402422	Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1
Q38150356	Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents
Q52364631	Tumor oxygenation and cancer therapy-then and now.
Q36607749	Tumor platinum concentration following intraperitoneal administration of cisplatin versus carboplatin in an ovarian cancer model
Q36218165	Tumor priming by Apo2L/TRAIL reduces interstitial fluid pressure and enhances efficacy of liposomal gemcitabine in a patient derived xenograft tumor model
Q42374224	Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas
Q37224751	Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy
Q36784603	Tumor-stromal interactions in pancreatic cancer
Q30495528	Tumors as organs: complex tissues that interface with the entire organism
Q37424066	Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice.
Q57814095	Tuning Pharmacokinetics to Improve Tumor Accumulation of a PSMA-Targeted Phototheranostic Agent
Q33895572	Tuning payload delivery in tumour cylindroids using gold nanoparticles
Q42533211	Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia
Q88680187	Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy
Q30488681	Ultrasound mediated delivery of drugs and genes to solid tumors
Q51005224	Ultrasound-Enhanced siRNA Delivery Using Magnetic Nanoparticle-Loaded Chitosan-Deoxycholic Acid Nanodroplets.
Q30396815	Ultrasound-Propelled Nanocups for Drug Delivery.
Q47546974	Ultrasound-mediated cavitation does not decrease the activity of small molecule, antibody or viral-based medicines.
Q58746739	Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy
Q30422904	Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors
Q33690336	Understanding Drug Resistance in Breast Cancer with Mathematical Oncology
Q41860837	Understanding and overcoming major barriers in cancer nanomedicine
Q38060202	Use of PD biomarkers to drive dose selection and early clinical decision making
Q51532050	Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors.
Q39248906	Utilizing Salmonella to treat solid malignancies.
Q33763847	Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth
Q37373632	Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?
Q58788212	Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET
Q27853196	Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer
Q92129704	Zerumbone Induces Apoptosis in Breast Cancer Cells by Targeting αvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide
Q38794978	iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice
Q47262466	iTRAQ Quantitative Proteomic Profiling and MALDI-MSI of Colon Cancer Spheroids Treated with Combination Chemotherapies in a 3D Printed Fluidic Device.
Q39977210	mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids
Q91690065	pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance
Q33674412	sTRAIL-iRGD is a promising therapeutic agent for gastric cancer treatment
Q35652276	α-Enolase-binding peptide enhances drug delivery efficiency and therapeutic efficacy against colorectal cancer

review article	Q7318358
scholarly article	Q13442814

P6179	Dimensions Publication ID	1017162057
P356	DOI	10.1038/NRC1893
P3181	OpenCitations bibliographic resource ID	387455
P698	PubMed publication ID	16862189

P50	author	Ian F. Tannock	Q106114426
P2093	author name string	Minchinton AI
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		Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines	Q36741477
		Immunocytochemical analysis of cisplatin-induced platinum-DNA adducts with double-fluorescence video microscopy	Q36875580
		Characterization of acidic vesicles in multidrug-resistant and sensitive cancer cells by acridine orange staining and confocal microspectrofluorometry	Q36880608
		Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer	Q37219981
		Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells	Q37352783
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		Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy	Q40349161
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		In vivo labelling with halogenated pyrimidines of squamous cell carcinomas and adjacent non‐involved mucosa of head and neck region	Q42479114
		Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.	Q42859352
		Factors that influence the penetration of methotrexate through solid tissue	Q43517179
		Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases	Q43858371
		Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture	Q45040866
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		Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.	Q52225958
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		The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.	Q54058144
		Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo.	Q54327891
		Cytotoxic drug penetration studies in multicellular tumour spheroids.	Q54382720
		Immunocytochemical localisation of VP16-213 in normal and malignant tissues.	Q54398618
		Resistance to adriamycin in multicellular spheroids	Q54568238
		Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids.	Q55488965
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		Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation	Q57662899
		A Rapid Method for studying Tumour Blood Supply using Systemic Dyes	Q59057221
		Variability of tumor response to chemotherapy. II. Contribution of tumor heterogeneity	Q68485005
		Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient	Q70043174
		Variable radiobiological responses of spheroids	Q72125120
		Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial	Q72182720
		Measurement of material extravasation in microvascular networks using fluorescence video-microscopy	Q72623570
		Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation	Q73034285
		Multilayers of cells growing on a permeable support. An in vitro tumour model	Q73197827
		In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy	Q74122408
		Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer	Q74562306
		Interstitial fluid pressure in cervical carcinoma: within tumor heterogeneity, and relation to oxygen tension	Q74681606
		Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors	Q77636379
P433	issue	8
P407	language of work or name	English	Q1860
P304	page(s)	583-92
P577	publication date	2006-08-01
P1433	published in	Nature Reviews Cancer	Q641657
P1476	title	Drug penetration in solid tumours
P478	volume	6

Drug penetration in solid tumours

scientific article (publication date: August 2006)

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