Tumor oxygenation and cancer therapy-then and now.

scientific article published on 7 March 2018

Tumor oxygenation and cancer therapy-then and now. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1259/BJR.20170955
P932PMC publication ID6435050
P698PubMed publication ID29513032

P50authorVeronica S HughesQ87821200
P2093author name stringDietmar W Siemann
Jennifer M Wiggins
P2860cites workComparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumorsQ77729027
Influence of the hypoxic subvolume on the survival of patients with head and neck cancerQ77936400
THE INFLUENCE OF ANEMIA ON THE RESULTS OF RADIOTHERAPY IN CARCINOMA OF THE CERVIXQ78291367
Some Aspects of the Effect of Ionizing Radiation on Tumors in Experimental AnimalsQ78911449
FDG--a marker of tumour hypoxia? A comparison with [18F]fluoromisonidazole and pO2-polarography in metastatic head and neck cancerQ79905758
The effect of smoking status on survival following radiation therapy for non-small cell lung cancerQ80081395
Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cellsQ80497165
Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trialQ83906570
VEGF-associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapyQ83917113
Acute versus chronic hypoxia: why a simplified classification is simply not enoughQ84387427
Longitudinal changes in tumor perfusion pattern during the radiation therapy course and its clinical impact in cervical cancerQ84582433
Hypoxic prostate/muscle PO2 ratio predicts for outcome in patients with localized prostate cancer: long-term resultsQ85069799
The role of pericytes in blood-vessel formation and maintenanceQ24683881
Relating oxygen partial pressure, saturation and content: the haemoglobin-oxygen dissociation curveQ26775258
The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?Q26823489
Immune Checkpoint Blockade in Cancer TherapyQ26830509
Targeting HIF-1 for cancer therapyQ27860504
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million AdultsQ28005550
Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiationQ28204294
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adductsQ28256408
Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology GroupQ28282755
Tirapazamine: a novel agent targeting hypoxic tumor cellsQ28302710
Drug penetration in solid tumoursQ29614404
Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensionsQ30449383
Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastasesQ30674169
Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical DataQ31112729
pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puQ33289243
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activationQ33569771
Hypoxia inducible factors in cancer stem cellsQ33708114
The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.Q33800899
Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetryQ33882791
Cardiovascular Late Effects and Exercise Treatment in Breast Cancer: Current Evidence and Future DirectionsQ33907581
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammationQ34028645
Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donationsQ34031084
Targeting hypoxic tumour cells to overcome metastasis.Q34086671
The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting AgentsQ34122191
RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of TsukubaQ34366604
Pro-inflammatory cytokines and adipose tissueQ34420482
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.Q34471121
Action of x-rays on mammalian cellsQ34648824
Hypoxia and radiation therapy: past history, ongoing research, and future promiseQ34986265
ARCON: a novel biology-based approach in radiotherapyQ35021325
OXYGEN TOXICITY.Q53978277
The Phenomenon of Reoxygenation and Its Implications for Fractionated RadiotherapyQ54193087
Role of Oxygen in Modifying the Radiosensitivity of E. Coli BQ59074413
Tumor Hypoxia Predicts Biochemical Failure following Radiotherapy for Clinically Localized Prostate CancerQ59363659
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survivalQ59647330
Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)Q64390275
Hypoxic cell sensitizers for radiotherapyQ67294358
Smoking: the influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiationQ67404508
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapyQ68327742
Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cellsQ69246621
A Posteffect of Oxygen in Irradiated Bacteria: A Submillisecond Fast Mixing StudyQ69260410
The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostateQ69599990
Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin CQ69974067
Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurementsQ70168020
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervixQ71545581
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neckQ71877350
Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathingQ72031099
The radiation response of KHT sarcomas following nicotinamide treatment and carbogen breathingQ72141361
Intercapillary distance, oxygen tension and local recurrence in cervix cancerQ72244042
Oxygen effect factor and tumor volume in the C3H mouse mammary carcinoma. A preliminary reportQ72753269
Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomasQ73223514
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapyQ73326377
Modification of Hypoxia-Induced Radioresistance in Tumors by the Use of Oxygen and SensitizersQ73548714
Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timingQ74019858
Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histographQ74434859
Definitive radiotherapy combined with high-dose-rate brachytherapy for Stage III carcinoma of the uterine cervix: retrospective analysis of prognostic factors concerning patient characteristics and treatment parametersQ74601281
The pivotal role of VEGF in tumor angiogenesis: molecular facts and therapeutic opportunitiesQ77402853
A model system for examining the radiosensitivity of metabolising layers of cellsQ39982756
The hypoxic tumor cell: a target for selective cancer chemotherapyQ40281971
Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. A reviewQ40405347
Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinomaQ40577663
Increased radiosensitivity with chronic hypoxia in four human tumor cell linesQ40697887
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroidsQ41248289
Mechanisms of transfusion-associated immunosuppressionQ41644441
Hypoxia regulates SOX2 expression to promote prostate cancer cell invasion and sphere formationQ41991455
Intratumoral pO2 predicts survival in advanced cancer of the uterine cervixQ42619534
Radiotherapy With Concurrent Carbogen and Nicotinamide in Bladder CarcinomaQ42855209
Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrodeQ42910923
Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferationQ43756144
Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.Q43760423
Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumoursQ44514473
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesisQ44975603
The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizersQ44986233
pO(2) Polarography versus positron emission tomography ([(18)F] fluoromisonidazole, [(18)F]-2-fluoro-2'-deoxyglucose). An appraisal of radiotherapeutically relevant hypoxiaQ45103730
The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2: 95% O2) on the in vivo radiation response of a murine sarcomaQ45105853
Pretreatment and midtreatment measurement of oxygen tension levels in head and neck cancersQ46076807
Repair of radiation induced damage--dependence on oxygen and energy statusQ46227545
Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervixQ46926510
Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancerQ47200841
Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer.Q48019142
Hypoxic prostate/muscle pO2 ratio predicts for biochemical failure in patients with prostate cancer: preliminary findingsQ49028556
Exercise and the Tumor Microenvironment: Potential Therapeutic ImplicationsQ49797060
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85.Q50561584
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.Q50649984
Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer.Q51795514
Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: results of a retrospective study of 386 patients.Q52542582
FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial.Q53136257
Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia.Q53204531
Carbogen breathing combined with radical radiotherapy in advanced head and neck cancer patients with severe co-morbidities.Q53605214
Immunohistochemical assessment of intrinsic and extrinsic markers of hypoxia in reproductive tissue: differential expression of HIF1α and HIF2α in rat oviduct and endometrium.Q35106512
Impact of hypoxia on the metastatic potential of human prostate cancer cellsQ35186588
Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.Q35259306
Hypoxic gene expression and metastasisQ35805259
Modulation of the tumor vasculature and oxygenation to improve therapyQ35920685
SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumoursQ35976983
Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring labelQ35992147
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivityQ36081569
Long-term results of radiation therapy oncology group 9903: a randomized phase 3 trial to assess the effect of erythropoietin on local-regional control in anemic patients treated with radiation therapy for squamous cell carcinoma of the head and necQ36311491
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
Hyperbaric oxygen therapy and cancer--a reviewQ36434876
Applicability of animal tumor data to cancer therapy in humansQ36445183
Intermittent blood flow in a murine tumor: radiobiological effectsQ36481293
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.Q36770262
Hypoxia and metastasis in breast cancer.Q36808477
Hypoxic radiosensitization: adored and ignoredQ36935082
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.Q37084096
Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistryQ37113797
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancerQ37299263
The relevance of a hypoxic tumour microenvironment in prostate cancerQ37627310
Modelling of the oxygen enhancement ratio for ion beam radiation therapyQ37871737
Imaging hypoxia to improve radiotherapy outcomeQ38059626
Prognostic factors in patients with bladder carcinoma treated with definitive irradiationQ38138805
Tumor hypoxia as a driving force in genetic instability.Q38155002
How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lectureQ38155899
Gene Expression Signatures as Biomarkers of Tumour HypoxiaQ38568536
Hypoxia and Predicting Radiation ResponseQ38588997
Antiangiogenic therapy in oncology: current status and future directionsQ38725587
Radiotherapy in the age of cancer immunology: Current concepts and future developments.Q38742020
Cancer Statistics, 2017.Q39038674
Tumor hypoxia and reoxygenation: the yin and yang for radiotherapyQ39061401
Tumor angiogenesis and vascular normalization: alternative therapeutic targetsQ39403862
Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probesQ39549694
Carbogen breathing during radiation therapy The radiation therapy oncology group studyQ39717134
The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanismsQ39725867
The histological structure of some human lung cancers and the possible implications for radiotherapyQ39979244
P433issue1093
P407language of work or nameEnglishQ1860
P304page(s)20170955
P577publication date2018-03-14
P1433published inBritish Journal of RadiologyQ15758529
P1476titleTumor oxygenation and cancer therapy-then and now
P478volume92

Reverse relations

cites work (P2860)
Q59791856Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer
Q56378964Hypoxia and IF₁ Expression Promote ROS Decrease in Cancer Cells
Q99630614Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
Q94293799Pushing the frontiers of radiobiology: A special feature in memory of Sir Oliver Scott and Professor Jack Fowler
Q94547387Signaling in and out: long-noncoding RNAs in tumor hypoxia
Q90449093The Different Routes to Metastasis via Hypoxia-Regulated Programs

Search more.