Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

scientific article

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2017.00125
P932PMC publication ID5432571
P698PubMed publication ID28559795

P50authorGalyna MaleevaQ84023366
Franck PeirettiQ37380786
P2093author name stringBoris S Zhorov
Piotr Bregestovski
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The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channelsQ28316466
Cyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channelsQ28369450
Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomersQ28378647
TMEM16A confers receptor-activated calcium-dependent chloride conductanceQ28590097
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemQ28623160
Magnesium gates glutamate-activated channels in mouse central neuronesQ29616237
Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?Q30461478
Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor.Q31121391
Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunitQ31886323
A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channelsQ31962028
Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric functionQ33527932
A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM dataQ33533542
Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.Q33560688
Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drugQ33967773
Monte Carlo-minimization approach to the multiple-minima problem in protein foldingQ34347829
Molecular structure and function of the glycine receptor chloride channelQ34350629
Glycine receptor antibodies in 2 cases of new, adult-onset epilepsy.Q34368647
Need to develop new nonsteroidal anti-inflammatory drug formulationsQ34400718
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.Q34407523
Strychnine binding associated with glycine receptors of the central nervous systemQ34737634
Electrophysiological properties of newborn and adult rat spinal cord glycine receptors expressed in Xenopus oocytes.Q35155261
Control of ethanol sensitivity of the glycine receptor α3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domainsQ35197866
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Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channelQ35626177
Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytesQ35873846
Enhancement of homomeric glycine receptor function by long-chain alcohols and anaestheticsQ35884602
Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium.Q36094250
Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channelsQ36176464
Ionic Blockage of Sodium Channels in NerveQ36388606
Inhibitory glycine receptors: an updateQ36418772
Glycine receptors: recent insights into their structural organization and functional diversityQ36521927
Ligand-gated ion channels in the brain: the amino acid receptor superfamilyQ36597573
Calibration and functional analysis of three genetically encoded Cl(-)/pH sensors.Q36774922
CLC chloride channels and transporters: a biophysical and physiological perspectiveQ36923173
Binding, activation and modulation of Cys-loop receptors.Q37680295
Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neuronesQ38179385
Efficacy and safety of morniflumate for the treatment of symptoms associated with soft tissue inflammationQ38447864
Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.Q39628706
Alpha2 subunit specificity of cyclothiazide inhibition on glycine receptors.Q40030131
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitizationQ40558217
Local anaesthetics transiently block currents through single acetylcholine-receptor channelsQ40676934
Short-term niflumic-acid-induced acute renal failure in children.Q40708559
Double-blind, placebo-controlled multicentre trial of the efficacy and tolerance of morniflumate suppositories in the treatment of tonsillitis in childrenQ40767856
Double-blind, placebo-controlled, multi-centre trial of the efficacy and tolerance of niflumic acid ('Nifluril') capsules in the treatment of tonsillitis in adultsQ40767902
Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor.Q40953630
Cloning, expression and electrophysiological characterization of glycine receptor alpha subunit from zebrafishQ40963009
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons.Q41659967
Selective potentiation of alpha 1 glycine receptors by ginkgolic acid.Q41997810
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptorsQ42206666
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.Q42428797
Access and binding of local anesthetics in the closed sodium channelQ42663202
Mechanisms for picrotoxin block of alpha2 homomeric glycine receptors.Q42675493
Functional geometry of the permeation pathway of Ca2+-activated Cl-channels inferred from analysis of voltage-dependent blockQ43560375
'Concentration-clamp' study of gamma-aminobutyric-acid-induced chloride current kinetics in frog sensory neurones.Q43811013
Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunitQ44585719
Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoidsQ45180302
Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structureQ46013119
Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumateQ46496890
Incidence of mucocutaneous reactions in children treated with niflumic acid, other nonsteroidal antiinflammatory drugs, or nonopioid analgesicsQ46522527
The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptorsQ46672123
Developmental expression of glycine receptor subunits in rat cerebellumQ46702969
Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolutionQ46815083
Light microscopic autoradiographic localisation of [3H]glycine and [3H]strychnine binding sites in rat brain.Q48319571
The distribution of glycine receptors in the human brain. A light microscopic autoradiographic study using [3H]strychnineQ48416958
Glycine receptor distribution in mouse CNS: autoradiographic localization of [3H]strychnine binding sitesQ48442690
TMEM16A alternative splicing isoforms in Xenopus tropicalis: distribution and functional properties.Q48605755
Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channelsQ49161290
P304page(s)125
P577publication date2017-05-16
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleVoltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
P478volume10

Reverse relations

cites work (P2860)
Q93072946A photoswitchable GABA receptor channel blocker
Q59335608Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons
Q98568568Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor

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