Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers

scientific article (publication date: October 1993)

Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/J.1460-2075.1993.TB06050.X
P3181OpenCitations bibliographic resource ID426281
P932PMC publication ID413654
P698PubMed publication ID8404844

P2093author name stringLangosch D
Betz H
Bormann J
Rundström N
P2860cites workGlycine-gated chloride current in acutely isolated rat hypothalamic neuronsQ69408553
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genesQ24301903
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
Pharmacology of GABA receptor CI− channels in rat retinal bipolar cellsQ28297635
The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channelsQ28316466
Functional chloride channels by mammalian cell expression of rat glycine receptor subunitQ28340468
Glycine receptor heterogeneity in rat spinal cord during postnatal developmentQ28359896
Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptorQ28573573
Isoform-selective deficit of glycine receptors in the mouse mutant spasticQ28589353
Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.Q33560688
Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamerQ33653057
Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptorQ33919478
Structure and function of inhibitory glycine receptorsQ35168987
What confers specificity on glycine for its receptor site?Q35756521
Fibroblasts transfected with Torpedo acetylcholine receptor beta-, gamma-, and delta-subunit cDNAs express functional receptors when infected with a retroviral alpha recombinantQ36220753
Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neuronesQ38179385
Protein oligomerization in the endoplasmic reticulumQ38737584
Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brainQ41081995
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptorsQ42206666
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductanceQ43509560
A characterization of glycinergic receptors present in cultured rat medullary neuronsQ48649820
Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channelsQ49161290
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.Q50789819
A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptorQ50797685
Inhibition of motoneurones by iontophoresis of glycine.Q53813566
Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in cultureQ54079720
Structural determinants of ion flow through recombinant glutamate receptor channelsQ57378348
Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABAQ59069378
The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteinsQ64379058
Ion channel formation by synthetic transmembrane segments of the inhibitory glycine receptor — a model studyQ67686773
Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channelQ67687450
Single-channel currents underlying glycinergic inhibitory postsynaptic responses in spinal neuronsQ67707735
Characteristics of glycine-activated conductances in cultured medullary neurons from embryonic ratQ69335949
Conductance states activated by glycine and GABA in rat cultured spinal neuronesQ69352322
Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptorQ69366000
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)3729-3737
P577publication date1993-10-01
P1433published inThe EMBO JournalQ1278554
P1476titleResidues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers
P478volume12

Reverse relations

cites work (P2860)
Q34924018A model of the glycine receptor deduced from Brownian dynamics studies
Q36265297A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells
Q24676418A novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexia
Q24295137A novel recessive hyperekplexia allele GLRA1 (S231R): genotyping by MALDI-TOF mass spectrometry and functional characterisation as a determinant of cellular glycine receptor trafficking
Q44815985A role for ligand-gated ion channels in rod photoreceptor development
Q36663814A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter
Q43842875Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells
Q52543205Activation of Cl- channels by avermectin in rat cultured hippocampal neurons.
Q28354074Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA
Q44445948Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons.
Q35156856Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure
Q77694440Allosteric receptors after 30 years
Q48007244Allosteric transitions of the acetylcholine receptor.
Q60228296Altered development in GABA co-release shapes glycinergic synaptic currents in cultured spinal slices of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis
Q33832609An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populations
Q40978330Baculovirus‐driven expression and purification of glycine receptor α1 homo‐oligomers
Q40700542Binding site stoichiometry and the effects of phosphorylation on human alpha1 homomeric glycine receptors.
Q49151457Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive
Q57494023Characterization of the Zebrafish Glycine Receptor Family Reveals Insights Into Glycine Receptor Structure Function and Stoichiometry
Q46477072Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability
Q40963009Cloning, expression and electrophysiological characterization of glycine receptor alpha subunit from zebrafish
Q40953630Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor.
Q35126661Correlating structural and energetic changes in glycine receptor activation.
Q74271419Cross-modulation of glycine-activated Cl- channels by protein kinase C and cAMP-dependent protein kinase in the rat
Q28369450Cyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channels
Q24568268Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
Q30483303Defective glycinergic synaptic transmission in zebrafish motility mutants
Q26738425Defects of the Glycinergic Synapse in Zebrafish
Q73067738Dendritic and postsynaptic localizations of glycine receptor alpha subunit mRNAs
Q30428679Development of glycinergic innervation to the murine LSO and SPN in the presence and absence of the MNTB
Q36492400Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Q72696097Differential expression of glycine receptor subunits in the retina of the rat: a study using immunohistochemistry and in situ hybridization
Q28588906Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator
Q48509164Distribution of the glycine receptor β-subunit in the mouse CNS as revealed by a novel monoclonal antibody.
Q64054228Diverse small molecules prevent macrophage lysis during pyroptosis
Q35873846Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes
Q39628706Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.
Q36689745Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles.
Q30371246Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses
Q28360652Exonic Sp1 sites are required for neural-specific expression of the glycine receptor beta subunit gene
Q40950251Expression cloning of the epithelial sodium channel
Q71707622Expression of glycine receptor subunits and gephyrin in single bipolar cells of the rat retina
Q37630015Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density
Q44087149Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra
Q35123262Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family
Q71691690Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors
Q57612075Functional properties of spontaneous IPSCs and glycine receptors in rod amacrine (AII) cells in the rat retina
Q34294157GABAergic inhibition of crayfish deep extensor abdominal muscle exhibits a steep dose-response relationship and a high degree of cooperativity
Q63433153Glycine Receptors
Q44599992Glycine Receptors and Glycinergic Synaptic Input at the Axon Terminals of Mammalian Retinal Rod Bipolar Cells
Q58618037Glycine Receptors in Cultured Chick Sympathetic Neurons are Excitatory and Trigger Neurotransmitter Release
Q47833208Glycine and GABA receptors in the mammalian retina
Q37614296Glycine as a neurotransmitter in the forebrain: a short review.
Q73055863Glycine-activated whole cell and single channel currents in rat cerebellar granule cells in culture
Q41707937Heritable mutations in the glycine, GABAA, and nicotinic acetylcholine receptors provide new insights into the ligand-gated ion channel receptor superfamily.
Q30485581High intracellular chloride slows the decay of glycinergic currents
Q36415753Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit
Q39321689Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.
Q28379427Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel
Q58728657Impaired Glycine Receptor Trafficking in Neurological Diseases
Q24304967Importance of Arg-219 for correct biogenesis of alpha 1 homooligomeric glycine receptors
Q34787233In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain
Q48238207Incremental conductance levels of GABAA receptors in dopaminergic neurones of the rat substantia nigra pars compacta.
Q36418772Inhibitory glycine receptors: an update
Q40147171Investigation of the alpha(1)-glycine receptor channel-opening kinetics in the submillisecond time domain
Q31886323Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit
Q40627198Kinetic analysis of recombinant mammalian alpha(1) and alpha(1)beta glycine receptor channels.
Q40905699Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors
Q24656965Kinetic determinants of agonist action at the recombinant human glycine receptor
Q44584006Kinetic properties of the alpha2 homo-oligomeric glycine receptor impairs a proper synaptic functioning.
Q27670592Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
Q46517240Localization of glycine receptor alpha subunits on bipolar and amacrine cells in primate retina
Q28584786Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice
Q34173431M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective
Q35847677Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption.
Q34987540Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
Q37249405Molecular architecture of glycinergic synapses
Q41592911Molecular biology of glycinergic neurotransmission
Q30391650Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation
Q28476717Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids
Q48382349Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons
Q52559453Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors.
Q42690651Novel GLRA1 missense mutation (P250T) in dominant hyperekplexia defines an intracellular determinant of glycine receptor channel gating
Q36636926Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease
Q36445119Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound
Q43101052Overexpression and functional characterization of the extracellular domain of the human alpha1 glycine receptor
Q46163607Patch-clamp analysis of glycine-induced currents in chick ciliary ganglion neurons
Q41680102Postsynaptic gephyrin immunoreactivity exhibits a nearly one‐to‐one correspondence with gamma‐aminobutyric acid‐like immunogold‐labeled synaptic inputs to sympathetic preganglionic neurons
Q45105996Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area.
Q45968297Properties of glycine receptors underlying synaptic currents in presynaptic axon terminals of rod bipolar cells in the rat retina.
Q48943899Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes
Q34162038Reciprocal developmental regulation of presynaptic ionotropic receptors
Q37395290Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors containing alpha1-subunits.
Q28344621Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila melanogaster GABA receptor (RDL) stably expressed in a Drosophila cell line
Q85554746Single mechanosensitive and Ca²⁺-sensitive channel currents recorded from mouse and human embryonic stem cells
Q28576583Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens
Q40018208Single-channel properties of glycine receptors of juvenile rat spinal motoneurones in vitro
Q90562742Specific synaptic input strengths determine the computational properties of excitation-inhibition integration in a sound localization circuit
Q57612066Spontaneous IPSCs and glycine receptors with slow kinetics in wide-field amacrine cells in the mature rat retina
Q40969262Stable expression of human glycine alpha1 and alpha2 homomeric receptors in mouse L(tk-) cells
Q34271863Structural conservation of ion conduction pathways in K channels and glutamate receptors
Q53794394Synaptic control of glycine and GABA(A) receptors and gephyrin expression in cultured motoneurons.
Q40946709The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor.
Q28578353The activation mechanism of alpha1 homomeric glycine receptors
Q24297403The beta subunit determines the ligand binding properties of synaptic glycine receptors
Q33907903The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study
Q37569543The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
Q34424350The glycine receptor
Q34297102The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex
Q51046390The kinetic properties of the α3 rat glycine receptor make it suitable for mediating fast synaptic inhibition.
Q37703420The multiple phenotypes of allosteric receptor mutants
Q41542849The pharmacology of amino-acid responses in septal neurons.
Q64459939The role of tonic glycinergic conductance in cerebellar granule cell signalling and the effect of gain-of-function mutation
Q42633764The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors.
Q100464367Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs
Q43908355Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors
Q30355589Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
Q37601095What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor
Q57985789Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum
Q30475957Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit

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