Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study.

scientific article

Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BPJ.2014.03.013
P932PMC publication ID4008790
P698PubMed publication ID24739167
P5875ResearchGate publication ID261747783

P50authorBen CorryQ41048411
Alice VrielinkQ57064314
P2093author name stringNatalie E Smith
Paul V Attwood
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Biological channeling of a reactive intermediate in the bifunctional enzyme DmpFG.Q35770014
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channelingQ43109869
Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI.Q43961131
Catalytic properties of a bacterial acylating acetaldehyde dehydrogenase: evidence for several active oligomeric states and coenzyme A activation upon binding.Q45181830
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation pathway.Q45922898
Peptide mimetics as enzyme inhibitors: use of free energy perturbation calculations to evaluate isosteric replacement for amide bonds in a potent HIV protease inhibitor.Q46016087
Mechanism of the dehydrogenase reaction of DmpFG and analysis of inter-subunit channeling efficiency and thermodynamic parameters in the overall reactionQ50930849
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.Q53186942
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI.Q53259775
Application of free energy simulations to the binding of a transition-state-analogue inhibitor to HTV proteaseQ68207882
Free energy calculations by computer simulationQ69004087
Rational design of stereoselectivity in the class II pyruvate aldolase BphIQ82496235
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmolecular dynamics simulationQ901663
P304page(s)1681-1690
P577publication date2014-04-01
P1433published inBiophysical JournalQ2032955
P1476titleBinding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study.
P478volume106

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cites work (P2860)
Q61444627Can enzyme proximity accelerate cascade reactions?
Q36289808Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?
Q58042970In Silico Studies of Small Molecule Interactions with Enzymes Reveal Aspects of Catalytic Function

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