Targeting Angiogenesis in Biliary Tract Cancers: An Open Option

scientific article

Targeting Angiogenesis in Biliary Tract Cancers: An Open Option is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS18020418
P932PMC publication ID5343952
P698PubMed publication ID28212293

P50authorNicola SilvestrisQ87916808
Marc PeetersQ38324454
Christian RolfoQ51069805
Domenico RibattiQ59681775
Oronzo BrunettiQ39379387
Eugenio MaioranoQ43298248
Antonio RussoQ46653000
P2093author name stringMario Testini
Aldo Scarpa
Luigi Lupo
Vito Longo
Amalia Azzariti
Valeria Simone
Michele Simone
P2860cites workExome sequencing of liver fluke-associated cholangiocarcinomaQ84073724
Prognostic impact of vascular endothelial growth factor-A expression in resected gallbladder carcinomaQ84792092
Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ88406073
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
Evading anti-angiogenic therapy: resistance to anti-angiogenic therapy in solid tumorsQ26773795
Cholangiocarcinoma: Current Knowledge and New DevelopmentsQ28076098
Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasisQ28216758
Guidelines for the diagnosis and treatment of cholangiocarcinoma: an updateQ28273143
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesQ29547633
Tumorigenesis and the angiogenic switchQ29619849
Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published dataQ31033443
A phase II study of sunitinib as a second-line treatment in advanced biliary tract carcinoma: a multicentre, multinational studyQ33398787
Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinomaQ33605089
Sorafenib in patients with advanced biliary tract carcinoma: a phase II trialQ33620083
Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium studyQ34048813
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitorsQ34104493
Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesisQ34344162
Vascular endothelial growth factor: basic science and clinical progressQ34549887
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancerQ34618537
Clinical diagnosis and staging of cholangiocarcinomaQ34631337
Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancersQ35023456
FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinomaQ35078039
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathwaysQ35190775
Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinomaQ35629462
HCC and angiogenesis: possible targets and future directionsQ35698574
Tumor necrosis factor-α promotes the lymphangiogenesis of gallbladder carcinoma through nuclear factor-κB-mediated upregulation of vascular endothelial growth factor-C.Q35713318
Nuclear factor-kappaB: the enemy withinQ35893620
Prognostic significance of microRNA-203 in cholangiocarcinomaQ36095393
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesisQ36111400
HIF-1α pathway: role, regulation and intervention for cancer therapyQ36238647
Circulating miR-106a is a Novel Prognostic and Lymph Node Metastasis Indicator for CholangiocarcinomaQ36245788
Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trialQ36287599
SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinomaQ36376264
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinomaQ36614705
Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancersQ36677934
Tumour-associated angiogenesis in human colorectal cancer.Q36689348
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomesQ36759538
Preclinical evaluation of sorafenib-eluting stent for suppression of human cholangiocarcinoma cellsQ36822722
A phase II study of gemcitabine and cisplatin plus sorafenib in patients with advanced biliary adenocarcinomas.Q37111209
Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinomaQ37177871
Drug resistance associated with antiangiogenesis therapyQ37518288
Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma.Q37588461
S0941: a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder carcinoma or cholangiocarcinomaQ37594373
Role of tumour-associated macrophages in cancer-related inflammationQ37853003
CD146, a multi-functional molecule beyond adhesionQ38069744
Histamine and histamine receptor regulation of gastrointestinal cancersQ38196813
Guidelines for the diagnosis and management of intrahepatic cholangiocarcinomaQ38200403
Differences in immunohistochemical biomarkers between intra- and extrahepatic cholangiocarcinoma: a systematic review and meta-analysisQ38208583
Angiogenesis in esophageal and gastric cancer: a paradigm shift in treatmentQ38216461
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinomaQ38804116
YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors.Q50577910
Genomic spectra of biliary tract cancer.Q53390123
Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras ActivationQ58450934
Tumor induction of VEGF promoter activity in stromal cellsQ77349243
Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesisQ77668037
Vascular endothelial growth factor expression is an independent negative predictor in extrahepatic biliary tract carcinomasQ78204868
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significanceQ82499254
Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinomaQ83080823
Lymphangiogenic and angiogentic microvessel density in gallbladder carcinomaQ83923681
Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation.Q38992520
Axitinib (AG-013736), an oral specific VEGFR TKI, shows potential therapeutic utility against cholangiocarcinomaQ39001956
Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo.Q39017898
miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF).Q39162380
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinomaQ39179249
Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinomaQ39325255
Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancerQ39445782
Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cellsQ39589946
Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma.Q39693531
H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.Q39787871
Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapyQ39995898
Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesisQ40582589
A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation modelQ40636256
A randomized, multicenter, phase II study of vandetanib monotherapy versus vandetanib in combination with gemcitabine versus gemcitabine plus placebo in subjects with advanced biliary tract cancer: the VanGogh studyQ41652822
Cholangiocarcinoma pathogenesis: Role of the tumor microenvironmentQ42029380
The prometastatic microenvironment of the liverQ42203607
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cellsQ42815794
Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 studyQ43237133
Tumor-associated angiogenesis and lymphangiogenesis correlate with progression of intrahepatic cholangiocarcinomaQ43846474
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesisQ44602053
Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomasQ44660500
Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomasQ44911533
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancersQ45704144
Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylaseQ46301097
Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programmeQ48058166
Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinomaQ50151361
Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinomaQ50176110
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttargeted therapyQ492646
angiogenesis inhibitorQ574834
neovascularizationQ1281049
biliary tract neoplasmQ18553364
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2017-02-15
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleTargeting Angiogenesis in Biliary Tract Cancers: An Open Option
P478volume18

Reverse relations

cites work (P2860)
Q95843571A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer
Q99580546A review of systemic therapy in biliary tract carcinoma
Q58605334Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell
Q90411340Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment
Q89835342Role of VEGFs/VEGFR-1 Signaling and its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models
Q50129481Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo
Q38654867The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer.
Q99352179Therapy of Primary Liver Cancer
Q47169336Tumor Microenvironment and Metabolism.

Search more.