Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

scientific article

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(15)00139-4
P932PMC publication ID4648082
P698PubMed publication ID26179201

P50authorCaroline DiveQ30119872
Alison BackenQ117194598
Juan ValleQ37830751
David CunninghamQ38803238
Srinivasan MadhusudanQ56435835
P2093author name stringJustin S Waters
Paul J Ross
Daniel H Palmer
D Alan Anthoney
Anthony Maraveyas
Harpreet Wasan
Charlotte Rees
Will P Steward
Karen Morris
Andre Lopes
Marian Duggan
Pippa Corrie
John A Bridgewater
Sandy Beare
P2860cites workMechanism of action and in vivo role of platelet-derived growth factorQ22010594
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancerQ28251373
A novel high-through-put assay for screening of pro-apoptotic drugsQ31105814
Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in JapanQ33390747
Sorafenib in patients with advanced biliary tract carcinoma: a phase II trialQ33620083
Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United StatesQ33949931
Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium studyQ34048813
‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial useQ58282597
Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cellsQ73075671
Vascular endothelial growth factor expression is an independent negative predictor in extrahepatic biliary tract carcinomasQ78204868
Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinomaQ80075002
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significanceQ82499254
Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancerQ34063503
A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.Q34241985
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancerQ34618537
Best supportive care compared with chemotherapy for unresectable gall bladder cancer: a randomized controlled studyQ34623625
Evaluation and validation of a robust single cell RNA-amplification protocol through transcriptional profiling of enriched lung cancer initiating cells.Q35060289
Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesisQ35711843
Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancerQ36385291
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinomaQ36614705
Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II studyQ36720049
Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer InQ37132598
Serum tumor markers in bile duct cancer--a review.Q38214343
Targeting PDGFR-β in CholangiocarcinomaQ39434606
Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapyQ39665887
Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 studyQ43237133
Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumorsQ43430750
Rising trends in cholangiocarcinoma: is the ICD classification system misleading us?Q44022677
Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomasQ44660500
Apoptosis generates stable fragments of human type I keratinsQ44865350
A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe.Q45045994
Optimisation of circulating biomarkers of cell death for routine clinical use.Q47884494
Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.Q48001140
Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programmeQ48058166
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system.Q55043149
Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanomaQ57569583
Circulating biomarkers in hepatocellular carcinomaQ58282111
Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung CancerQ58282332
Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung CancerQ58282415
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectplaceboQ269829
cisplatinQ412415
chemotherapyQ974135
???Q18556397
phase II clinical trialQ42824440
P304page(s)967-978
P577publication date2015-07-12
P1433published inLancet Oncology CommissionQ13747613
P1476titleCediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial
P478volume16

Reverse relations

cites work (P2860)
Q95843571A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer
Q35934963A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study
Q64134451A phase 2 trial of regorafenib as a single agent in patients with chemotherapy-refractory, advanced, and metastatic biliary tract adenocarcinoma
Q60961748Apatinib for treating advanced intrahepatic cholangiocarcinoma after failed chemotherapy: A case report and literature review
Q39289707Biliary cancer: intrahepatic cholangiocarcinoma vs. extrahepatic cholangiocarcinoma vs. gallbladder cancers: classification and therapeutic implications
Q60927301Biliary tract cancer: current challenges and future prospects
Q64101426Biliary tract cancers: current knowledge, clinical candidates and future challenges
Q57456582Cardiovascular Toxicities with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Meta-Analysis of 77 Randomized Controlled Trials
Q34520190Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.
Q85605167Chemotherapy and antiangiogenics in biliary tract cancer
Q36107068Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials
Q96817624Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Q89170919Circulating biomarkers during treatment in patients with advanced biliary tract cancer receiving cediranib in the UK ABC-03 trial
Q97419371Comprehensive molecular profiling of intrahepatic cholangiocarcinoma in the Chinese population and therapeutic experience
Q92591396Contemporary Tailored Oncology Treatment of Biliary Tract Cancers
Q40824695Correlations of survival with progression-free survival, response rate, and disease control rate in advanced biliary tract cancer: a meta-analysis of randomised trials of first-line chemotherapy
Q38830071Current Progress in Immunotherapy for the Treatment of Biliary Cancers
Q39453572Current biologics for treatment of biliary tract cancers
Q53814608Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma.
Q33440859Efficacy and safety of chemotherapy with or without targeted therapy in biliary tract cancer: A meta-analysis of 7 randomized controlled trials
Q33436600Efficacy and toxicities of adding molecular targeted agents to first-line chemotherapy in the treatment of advanced biliary tract cancer: a systematic review and meta-analysis
Q38642455Emerging molecular targets and therapy for cholangiocarcinoma
Q37631655From Clinical Standards to Translating Next-Generation Sequencing Research into Patient Care Improvement for Hepatobiliary and Pancreatic Cancers
Q55481891Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico.
Q57211742Gemcitabine-based chemotherapy for advanced biliary tract carcinomas
Q39040859HER2/HER3 pathway in biliary tract malignancies; systematic review and meta-analysis: a potential therapeutic target?
Q38703148Immunotherapeutic Approaches to Biliary Cancer
Q39186928Intrahepatic cholangiocarcinoma: current management and emerging therapies
Q92251015Landscape of distant metastasis mode and current chemotherapy efficacy of the advanced biliary tract cancer in the United States, 2010-2016
Q47429093MIR21 drives resistance to Heat Shock Protein 90 inhibition in cholangiocarcinoma
Q39385781Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells
Q39521003Meta-analysis of the incidence and risk of arterial and venous thromboembolic events associated with anti-EGFR agents in non-small-cell lung cancer patients
Q64085995Molecular Pathogenesis of Cholangiocarcinoma
Q92029922Molecular targets in cholangiocarcinoma
Q38619219New Horizons for Precision Medicine in Biliary Tract Cancers
Q90308323New and Emerging Systemic Therapeutic Options for Advanced Cholangiocarcinoma
Q54476966New molecular and immunotherapeutic approaches in biliary cancer.
Q38799963Novel investigational therapies for treating biliary tract carcinoma
Q37305538Pediatric Kawasaki Disease and Adult Human Immunodeficiency Virus Kawasaki-Like Syndrome Are Likely the Same Malady
Q58599860Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
Q48214785Predictive Value of Early Skin Rash in Cetuximab-Based Therapy of Advanced Biliary Tract Cancer.
Q48203761Prognostic and predictive role of EGFR pathway alterations in biliary cancer patients treated with chemotherapy and anti-EGFR.
Q57118798Ramucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open-Label, Phase I Trial (JVDF)
Q60910477Safety and efficacy of afatinib as add-on to standard therapy of gemcitabine/cisplatin in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, phase I trial with an extensive biomarker program
Q57463236Second-line chemotherapy in patients with advanced or recurrent biliary tract cancer: a single center, retrospective analysis of 294 cases
Q92460033Second-line therapies in advanced biliary tract cancers
Q33688577Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.
Q50526996Survival Benefits of Surgical Resection in Patients with Recurrent Biliary Tract Carcinoma.
Q49627919Systemic and Adjuvant Therapies for Intrahepatic Cholangiocarcinoma
Q64249982Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials
Q30398807Targeting Angiogenesis in Biliary Tract Cancers: An Open Option
Q60922992The Efficacy and Safety of First-line Chemotherapies for Advanced Biliary Tract Cancer: A Network Meta-analysis
Q92703974The Efficacy of Different Chemotherapy Regimens for Advanced Biliary Tract Cancer: A Systematic Review and Network Meta-Analysis
Q37393508The Wnt/β-catenin signaling pathway mechanism for pancreatic cancer chemoresistance in a three-dimensional cancer microenvironment
Q47139810The efficacy and safety of different pharmacological interventions for patients with advanced biliary tract cancer: A network meta-analysis
Q26751224The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets
Q33656860The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer
Q33621529Therapeutic options for intrahepatic cholangiocarcinoma
Q57073983Treatment with olaparib monotherapy for BRCA2-mutated refractory intrahepatic cholangiocarcinoma: a case report
Q90045641Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study

Search more.