Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.

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Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3. is …
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scholarly articleQ13442814

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P356DOI10.1002/CM.21179
P932PMC publication ID4347929
P698PubMed publication ID24922351
P5875ResearchGate publication ID263053069

P50authorVelia FowlerQ67189313
P2093author name stringDavid S Gokhin
Sawako Yamashiro
Raymond A Lewis
P2860cites workTropomyosin requires an intact N-terminal coiled coil to interact with tropomodulinQ24537515
Tropomodulin caps the pointed ends of actin filamentsQ24672951
Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motilityQ24675095
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Tropomodulin capping of actin filaments in striated muscle development and physiologyQ26852179
Latrunculin alters the actin-monomer subunit interface to prevent polymerizationQ27624918
Tropomyosin isoforms: divining rods for actin cytoskeleton functionQ28256249
Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscleQ28300662
Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liverQ28504865
Structural requirements of tropomodulin for tropomyosin binding and actin filament cappingQ28571101
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethalityQ28588176
Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiologyQ28589016
Structure and tropomyosin binding properties of the N-terminal capping domain of tropomodulin 1.Q28909751
Actin: protein structure and filament dynamics.Q30381954
Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms.Q30405662
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeletonQ30496964
Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibersQ30560184
In vitro and in vivo characterization of four fibroblast tropomyosins produced in bacteria: TM-2, TM-3, TM-5a, and TM-5b are co-localized in interphase fibroblastsQ33198936
Tropomyosin prevents depolymerization of actin filaments from the pointed endQ68618411
Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag periodQ68780226
Identification and purification of a novel Mr 43,000 tropomyosin-binding protein from human erythrocyte membranesQ69222543
Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerizationQ69415388
Purification of muscle actinQ70410249
Erythrocyte membrane tropomyosin. Purification and propertiesQ71327471
21 Preparation and identification of α- and β-tropomyosinsQ72952643
Tropomodulin increases the critical concentration of barbed end-capped actin filaments by converting ADP.P(i)-actin to ADP-actin at all pointed filament endsQ73212015
Tropomyosin exon 6b is troponin-specific and required for correct acto-myosin regulationQ75366742
Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesionsQ77124233
Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscleQ81517487
Systematic analysis of tropomodulin/tropomyosin interactions uncovers fine-tuned binding specificity of intrinsically disordered proteinsQ84127722
Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryoQ33651020
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.Q33874993
Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5.Q33907210
Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities.Q34236824
Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletonsQ34325825
Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytesQ34503247
Tmod3 regulates polarized epithelial cell morphologyQ34700120
Tropomyosin-based regulation of the actin cytoskeleton in time and spaceQ34736000
Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibersQ35102445
Molecular basis of tropomyosin binding to tropomodulin, an actin-capping proteinQ36259368
The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytesQ36323337
Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytesQ36620808
Tropomodulins and tropomodulin/tropomyosin interactionsQ36983805
Tropomodulin binds two tropomyosins: a novel model for actin filament cappingQ37000615
Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegansQ37041560
Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic developmentQ37348318
Disease severity and thin filament regulation in M9R TPM3 nemaline myopathy.Q37351987
Tropomyosin: function follows structureQ37390505
Cooperative binding of tropomyosin to actin.Q37390512
Tropomodulin/tropomyosin interactions regulate actin pointed end dynamics.Q37390558
Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.Q38001405
Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl groupQ38309278
Expression and biological activity of Baculovirus generated wild-type human slow alpha tropomyosin and the Met9Arg mutant responsible for a dominant form of nemaline myopathyQ40712861
Requirement of amino-terminal modification for striated muscle alpha-tropomyosin functionQ41441330
Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filamentsQ41523947
Inhibition of actin polymerization by latrunculin A.Q42217562
Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actinQ42762718
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytesQ43941100
Isoform-specific interaction of tropomodulin with skeletal muscle and erythrocyte tropomyosins.Q44405927
Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D.Q44614660
Effect of the structure of the N terminus of tropomyosin on tropomodulin functionQ44683440
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrilsQ46491655
Actin dynamics at pointed ends regulates thin filament length in striated muscleQ46871996
Tropomodulin contains two actin filament pointed end-capping domainsQ46897924
Tropomodulin binding to tropomyosins. Isoform-specific differences in affinity and stoichiometryQ48497952
Altered actin and troponin binding of amino-terminal variants of chicken striated muscle alpha-tropomyosin expressed in Escherichia coli.Q54763296
Equilibrium of the actin-tropomyosin interactionQ66974075
Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosinQ67288786
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)395-411
P577publication date2014-07-02
P1433published inCytoskeletonQ2196987
P1476titleFunctional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.
P478volume71