Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes

scientific article

Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.186924
P932PMC publication ID3023515
P698PubMed publication ID21078668

P50authorAndrey V KajavaQ92961361
P2093author name stringCarol C Gregorio
Alla S Kostyukova
Brinda Desai
Lucy Kotlyanskaya
Robert Huynh
Stefanie M Novak
Takehiro Tsukada
P2860cites workEffect of the structure of the N terminus of tropomyosin on tropomodulin functionQ44683440
Actin dynamics at pointed ends regulates thin filament length in striated muscleQ46871996
Tropomodulin contains two actin filament pointed end-capping domainsQ46897924
Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation.Q52564686
Leiomodins: larger members of the tropomodulin (Tmod) gene family.Q55034758
Hormonal regulation of myosin heavy chain and alpha-actin gene expression in cultured fetal rat heart myocytesQ69906507
Domain structure of tropomodulin: distinct properties of the N-terminal and C-terminal halvesQ73072354
The shapes and sizes of two domains of tropomodulin, the P-end-capping protein of actin-tropomyosinQ73965331
Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulinQ24537515
Crystal structure of the C-terminal half of tropomodulin and structural basis of actin filament pointed-end cappingQ27639906
The leucine-rich repeat as a protein recognition motifQ28212461
Structural requirements of tropomodulin for tropomyosin binding and actin filament cappingQ28571101
Cytoplasmic nuclear transfer of the actin-capping protein tropomodulinQ28574406
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethalityQ28588176
Structure and tropomyosin binding properties of the N-terminal capping domain of tropomodulin 1.Q28909751
Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*Q29555850
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile miceQ30500685
Nebulin regulates actin filament lengths by a stabilization mechanism.Q33886832
Molecular basis of tropomyosin binding to tropomodulin, an actin-capping proteinQ36259368
The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytesQ36323337
Nebulin interacts with CapZ and regulates thin filament architecture within the Z-discQ36631194
Tropomodulins and tropomodulin/tropomyosin interactionsQ36983805
Tropomodulin binds two tropomyosins: a novel model for actin filament cappingQ37000615
Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin rulerQ37269778
Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic developmentQ37348318
Folding properties of functional domains of tropomodulinQ40186280
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytesQ43941100
E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulationQ44288613
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectactin filamentQ329638
P304page(s)2194-2204
P577publication date2010-11-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes
P478volume286

Reverse relations

cites work (P2860)
Q28512007Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy
Q38692012Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.
Q36620808Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes
Q42375826Cardiac leiomodin2 binds to the sides of actin filaments and regulates the ATPase activity of myosin
Q50972239Cooperative effects of tropomyosin on the dynamics of the actin filament.
Q30405662Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms.
Q30407577Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.
Q28119066How Leiomodin and Tropomodulin use a common fold for different actin assembly functions
Q34961638Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis
Q37365592Localization of the binding interface between leiomodin-2 and α-tropomyosin
Q27684814Mechanism of actin filament pointed-end capping by tropomodulin
Q39895735Mutations changing tropomodulin affinity for tropomyosin alter neurite formation and extension
Q37998785Refined views of multi-protein complexes in the erythrocyte membrane
Q90107379Role of intrinsic disorder in muscle sarcomeres
Q33598667Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes
Q37175795The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function.
Q26740620The Role of Leucine-Rich Repeat Containing Protein 10 (LRRC10) in Dilated Cardiomyopathy
Q91597359Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1.
Q26852179Tropomodulin capping of actin filaments in striated muscle development and physiology
Q37026817Tropomodulin isoforms utilize specific binding functions to modulate dendrite development
Q30625919Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
Q38791519Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles
Q36640510Tropomodulins and tropomyosins: working as a team
Q38001405Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.
Q37365595Tropomyosin-binding properties modulate competition between tropomodulin isoforms

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