Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin

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Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin is …
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scholarly articleQ13442814

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P356DOI10.1016/S0006-3495(02)75600-2
P8608Fatcat IDrelease_acgdnuae2jgz3nxmwy7jcfxpru
P932PMC publication ID1302047
P698PubMed publication ID11964245

P50authorVelia FowlerQ67189313
P2093author name stringNorma J Greenfield
P2860cites workSequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologsQ22011210
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Tropomodulin caps the pointed ends of actin filamentsQ24672951
Differential localization of tropomyosin isoforms in cultured nonmuscle cellsQ24679759
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
An Algorithm for Least-Squares Estimation of Nonlinear ParametersQ26778383
Deciphering the design of the tropomyosin moleculeQ27632998
Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric proteinQ27635078
Tropomodulin binding to tropomyosins. Isoform-specific differences in affinity and stoichiometryQ48497952
The stability of tropomyosin, a two-stranded coiled-coil protein, is primarily a function of the hydrophobicity of residues at the helix-helix interface.Q52320819
Analysis of the circular dichroism spectrum of proteins using the convex constraint algorithm: a practical guide.Q52421166
Quantitative analysis of protein far UV circular dichroism spectra by neural networksQ52423418
The structure of the amino terminus of tropomyosin is critical for binding to actin in the absence and presence of troponin.Q54750069
Altered actin and troponin binding of amino-terminal variants of chicken striated muscle alpha-tropomyosin expressed in Escherichia coli.Q54763296
Leiomodins: larger members of the tropomodulin (Tmod) gene family.Q55034758
The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)nQ67555188
Tropomyosin prevents depolymerization of actin filaments from the pointed endQ68618411
Identification and purification of a novel Mr 43,000 tropomyosin-binding protein from human erythrocyte membranesQ69222543
Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerizationQ69415388
Expression of smooth muscle and nonmuscle tropomyosins in Escherichia coli and characterization of bacterially produced tropomyosinsQ70622133
Determination of protein secondary structure in solution by vacuum ultraviolet circular dichroismQ71306178
Poly(pro)II helices in globular proteins: identification and circular dichroic analysisQ72130288
Alpha-helical coiled coils: more facts and better predictionsQ72730343
Domain structure of tropomodulin: distinct properties of the N-terminal and C-terminal halvesQ73072354
Tropomodulin increases the critical concentration of barbed end-capped actin filaments by converting ADP.P(i)-actin to ADP-actin at all pointed filament endsQ73212015
Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosinQ74431841
The structure of the N-terminus of striated muscle alpha-tropomyosin in a chimeric peptide: nuclear magnetic resonance structure and circular dichroism studiesQ27757862
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
Predicting coiled coils from protein sequencesQ27861097
Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding regionQ28199174
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathyQ28299243
The amino terminus of muscle tropomyosin is a major determinant for functionQ28306422
N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosinQ28567779
Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulationQ28568741
Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*Q29555850
The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.Q31443852
Putting a new twist on actin: ADF/cofilins modulate actin dynamicsQ33719401
Progress in protrusion: the tell-tale scar.Q33763335
Inherited disorders of sarcomeric proteinsQ33790253
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.Q33874993
Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5.Q33907210
Alteration of tropomyosin function and folding by a nemaline myopathy-causing mutation.Q34174588
Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin geneQ34328399
Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly.Q36235536
Conformational intermediates in the folding of a coiled-coil model peptide of the N-terminus of tropomyosin and alpha alpha-tropomyosinQ36278160
Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curvesQ36472087
Estimation of binding parameters of enzyme-ligand complex from fluorometric data by a curve fitting procedure: seryl-tRNA synthetase-tRNA Ser complexQ36521883
Nemaline myopathy rod bodies. Structure and compositionQ36627927
Methods to estimate the conformation of proteins and polypeptides from circular dichroism dataQ36824816
Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative RNA splicing and polyadenylationQ36898282
Alpha-helical coiled coils and bundles: how to design an alpha-helical proteinQ37918087
Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl groupQ38309278
Structure-function relationships in smooth muscle: the missing linksQ41078493
Thin filament-mediated regulation of cardiac contractionQ41117735
Tropomyosin isoforms in nonmuscle cells.Q41322774
Requirement of amino-terminal modification for striated muscle alpha-tropomyosin functionQ41441330
Predicting coiled-coil regions in proteinsQ41515819
The ends of tropomyosin are major determinants of actin affinity and myosin subfragment 1-induced binding to F-actin in the open state.Q42616670
Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actinQ42762718
The amino acid sequence of rabbit skeletal alpha-tropomyosin. The NH2-terminal half and complete sequenceQ43665623
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytesQ43941100
Isoform-specific interaction of tropomodulin with skeletal muscle and erythrocyte tropomyosins.Q44405927
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrilsQ46491655
Actin dynamics at pointed ends regulates thin filament length in striated muscleQ46871996
Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoformsQ48086775
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
P304page(s)2580-2591
P577publication date2002-05-01
P1433published inBiophysical JournalQ2032955
P1476titleTropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin
P478volume82

Reverse relations

cites work (P2860)
Q38692012Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.
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Q34487710Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres
Q37365592Localization of the binding interface between leiomodin-2 and α-tropomyosin
Q36259368Molecular basis of tropomyosin binding to tropomodulin, an actin-capping protein
Q47887165Myofibrillogenesis in the developing chicken heart: role of actin isoforms and of the pointed end actin capping protein tropomodulin during thin filament assembly
Q90107379Role of intrinsic disorder in muscle sarcomeres
Q47378513Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H.
Q34179208Structure and interactions of the carboxyl terminus of striated muscle alpha-tropomyosin: it is important to be flexible
Q43123353Structure and orientation of troponin in the thin filament
Q28909751Structure and tropomyosin binding properties of the N-terminal capping domain of tropomodulin 1.
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Q38667667The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics
Q36323337The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes
Q91597359Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1.
Q34570441Tropomodulin 3 binds to actin monomers
Q37000615Tropomodulin binds two tropomyosins: a novel model for actin filament capping
Q26852179Tropomodulin capping of actin filaments in striated muscle development and physiology
Q28589016Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
Q36640510Tropomodulins and tropomyosins: working as a team
Q38001405Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.
Q34181125Tropomyosin ends determine the stability and functionality of overlap and troponin T complexes
Q42926452Tropomyosin period 3 is essential for enhancement of isometric tension in thin filament-reconstituted bovine myocardium

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