A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence

scientific article

A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/ADM.0B013E31829623F4
P932PMC publication ID3914416
P698PubMed publication ID23728065

P50authorRobert L StoutQ47568798
Helen Marie PettinatiQ109580310
P2093author name stringAlan I Green
Mary F Brunette
Charles Scott
Daniel E Falk
Domenic A Ciraulo
Eric C Strain
Janet Ransom
Joanne B Fertig
Kelly E Dunn
Kyle Kampman
Megan L Ryan
Raye Z Litten
Bankole Johnson
Nassima A Tiouririne
Ofra Sarid-Segal
NCIG (National Institute on Alcohol Abuse and Alcoholism Clinical Investigations Group) Study Group
P2860cites workA comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.Q27860879
A power primerQ27861029
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptorsQ28245329
The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10Q29547745
The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance QuestionnaireQ29615435
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disordersQ29615543
Topiramate for treating alcohol dependence: a randomized controlled trialQ30444701
The genetic components of alcohol and nicotine co-addiction: from genes to behaviorQ30489302
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seekingQ30502320
Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J miceQ33709932
Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptorsQ33770793
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administrationQ33820862
Varenicline reduces alcohol self-administration in heavy-drinking smokersQ33825408
Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient dataQ34012163
Economic costs of excessive alcohol consumption in the U.S., 2006.Q34225570
Varenicline decreases alcohol consumption in heavy-drinking smokersQ34271996
Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?Q34306652
A simulation study of the number of events per variable in logistic regression analysisQ34411363
The relation between different dimensions of alcohol consumption and burden of disease: an overviewQ35835324
Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review.Q36039402
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictionsQ36137598
Medications development to treat alcohol dependence: a vision for the next decadeQ36357552
Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism.Q36764752
Alcohol's actions on neuronal nicotinic acetylcholine receptors.Q36764756
A preliminary investigation of varenicline for heavy drinking smokersQ36821304
Addiction and dependence in DSM-VQ37267779
Helping patients who drink too much: an evidence-based guide for primary care cliniciansQ37557570
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.Q38405712
Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control.Q41862387
Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcoholQ43940291
Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbensQ43940320
The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002.Q44934071
Epidemiology and alcohol policy in EuropeQ44973068
The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine systemQ46173380
Does effect size in naltrexone trials for alcohol dependence differ for single-site vs. multi-center studies?Q46565128
Involvement of nicotinic receptors in alcohol self-administration.Q52170503
Psychometric properties of the Penn Alcohol Craving Scale.Q52277465
Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study.Q52291108
Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J miceQ82634100
P433issue4
P921main subjecttartrateQ425046
alcohol dependenceQ4713263
placeboQ269829
vareniclineQ411330
placebo-controlled trialQ108853737
P304page(s)277-286
P577publication date2013-07-01
P1433published inJournal of Addiction MedicineQ15752435
P1476titleA double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence
P478volume7

Reverse relations

cites work (P2860)
Q33720707"Killing Two Birds with One Stone": Alcohol Use Reduction Interventions with Potential Efficacy in Enhancing Self-Control
Q54998102A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking.
Q30275691A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence
Q27312608A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration
Q34785056A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers
Q38940577Addiction, cognitive decline and therapy: seeking ways to escape a vicious cycle.
Q47182010Advances in Pharmacotherapy Development: Human Clinical Studies
Q90450428Advances in the science and treatment of alcohol use disorder
Q92312184Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder
Q48081263Alcohol medications development: advantages and caveats of government/academia collaborating with the pharmaceutical industry
Q38581812Alcohol use disorders.
Q49236388Alcohol-Induced Increases in Inflammatory Cytokines Are Attenuated by Nicotine in Region-Selective Manner in Male Rats
Q89314072Alterations in resting-state functional connectivity in substance use disorders and treatment implications
Q36103548An exploratory evaluation of Take Control: A novel computer-delivered behavioral platform for placebo-controlled pharmacotherapy trials for alcohol use disorder
Q104460866An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study
Q38839642An overview of alcohol and tobacco/nicotine interactions in the human laboratory
Q64983524Association of Syndemic Unhealthy Alcohol Use, Cigarette Use, and Depression With All-Cause Mortality Among Adults Living With and Without HIV Infection: Veterans Aging Cohort Study.
Q61822090Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Q30841324Automatic avoidance tendencies for alcohol cues predict drinking after detoxification treatment in alcohol dependence
Q92189687Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future
Q38594528Clinical neuroscience of addiction: similarities and differences between alcohol and other drugs
Q48148853Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking in Alcohol-Preferring (P) Rats.
Q34351761Cognitive control in alcohol use disorder: deficits and clinical relevance
Q38185313Combined pharmacotherapies for the management of alcoholism: rationale and evidence to date
Q36372867Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
Q36877440Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers
Q38181213Current pharmacological treatment approaches for alcohol dependence
Q90597805Developing neuroscience-based treatments for alcohol addiction: A matter of choice?
Q90308784Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice
Q37059221Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development
Q33929790Drug effects on multiple and concurrent schedules of ethanol- and food-maintained behaviour: context-dependent selectivity
Q36936258Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders
Q47275723Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial
Q37059266Effect of Varenicline Combined with High-Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings
Q48180557Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
Q50042559Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study
Q36363819Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers
Q49892752Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats
Q38732866Effects of varenicline on alcohol cue reactivity in heavy drinkers
Q38870727Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Q48124586Effects of varenicline on cognitive performance in heavy drinkers: Dose-response effects and associations with drinking outcomes
Q34940888Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization
Q36319552Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse
Q38689594Emerging pharmacotherapies for alcohol use disorder
Q92326041Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials
Q43195621Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: behavioral and electrophysiological findings.
Q38636469Feeding Two Birds with One Scone: The Case of Varenicline
Q52316006From gene networks to drugs: systems pharmacology approaches for AUD.
Q58591817Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial assessing Efficacy and Safety
Q34970821Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption
Q36231851Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision
Q99608705Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients
Q42623009Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates
Q47732515Letter to Editor in Response to Johnson's Commentary (2017) on the Witkiewitz and Colleagues (2017) Article
Q62729760Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking
Q37060159Management of Alcohol Use Disorder in Patients Requiring Liver Transplant
Q30399710Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum
Q38718932Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models
Q47942161Medications for alcohol use disorders: An overview
Q30871554Methods to analyze treatment effects in the presence of missing data for a continuous heavy drinking outcome measure when participants drop out from treatment in alcohol clinical trials
Q34048818MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells.
Q58131549Missed opportunities to test the neuropsychiatric safety--and efficacy--of varenicline among smokers with substance use disorders
Q35911952Moderators of Varenicline Treatment Effects in a Double-Blind, Placebo-Controlled Trial for Alcohol Dependence: An Exploratory Analysis
Q24185773Nicotine receptor partial agonists for smoking cessation
Q50065382Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence
Q35960331Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine
Q28087047Nicotinic receptor modulation to treat alcohol and drug dependence
Q39136644Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors
Q89402756Overcoming the "Valley of Death" in Medications Development for Alcohol Use Disorder
Q36294656Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers
Q37708082Pharmacological approaches to reducing craving in patients with alcohol use disorders
Q36684437Pharmacotherapy for alcohol use disorder: current and emerging therapies
Q36927085Pharmacotherapy of Co-Occurring Schizophrenia and Substance Use Disorders
Q43061723Pharmacotherapy of alcoholism - an update on approved and off-label medications
Q50317988Practical outpatient pharmacotherapy for alcohol use disorder
Q37059156Preclinical Medication Development: New Targets and New Drugs
Q92501996Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption
Q36440595Recruitment techniques for alcohol pharmacotherapy clinical trials: A cost-benefit analysis
Q47616924Reduced Drinking in Alcohol Dependence Treatment, What Is the Evidence?
Q41528453Relative potency of varenicline or fluvoxamine to reduce responding for ethanol versus food depends on the presence or absence of concurrently earned food
Q28083649Risk of neuropsychiatric adverse events associated with varenicline: systematic review and meta-analysis
Q41477480Safety and tolerability of as-needed nalmefene in the treatment of alcohol dependence: results from the Phase III clinical programme
Q58100058State-of-the-art behavioral and pharmacological treatments for alcohol use disorder
Q34096925Substance abuse among older adults
Q34247817Substance use in older HIV-infected patients
Q99581955Suicide Attempt in a 38-Year-Old Patient on Varenicline While Intoxicated With Alcohol
Q48305886The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?
Q47442429The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers.
Q48248956The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats
Q48143336The Glycine Receptor-A Functionally Important Primary Brain Target of Ethanol.
Q41392387The monoamine stabilizer (-)-OSU6162 counteracts downregulated dopamine output in the nucleus accumbens of long-term drinking Wistar rats
Q47550611The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption
Q35788371The role of varenicline on alcohol-primed self-administration and seeking behavior in rats
Q91649780Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking
Q26799819Translating Alcohol Research: Opportunities and Challenges
Q48004085Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats.
Q39196596Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens
Q33929766Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens
Q43188062Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats.
Q34097966Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals
Q50088319Varenicline for tobacco-dependence treatment in alcohol-dependent smokers: A randomized controlled trial
Q40491939Varenicline for treatment of alcohol dependence: a randomized, placebo-controlled trial
Q35219810Varenicline in the treatment of alcohol use disorders
Q88959955Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial
Q47373861Varenicline versus nicotine patch with brief advice for smokers with substance use disorders with or without depression: effects on smoking, substance use and depressive symptoms