Varenicline reduces alcohol self-administration in heavy-drinking smokers

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Varenicline reduces alcohol self-administration in heavy-drinking smokers is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BIOPSYCH.2009.01.029
P932PMC publication ID2863311
P698PubMed publication ID19249750
P5875ResearchGate publication ID24144419

P50authorSherry A McKeeQ92194846
Jeanette M. TetraultQ113470629
Marina PicciottoQ40057362
Suchitra Krishnan-SarinQ47498682
P2093author name stringJulia Shi
Stephanie S O'Malley
Ismene L Petrakis
Emily L R Harrison
Erika Balchunas
Naralys Estevez
P2860cites workVarenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessationQ28250054
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitizationQ28588299
Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens.Q48329536
Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamineQ48346302
Signs and symptoms of tobacco withdrawalQ49016637
Mortality following inpatient addictions treatment. Role of tobacco use in a community-based cohort.Q51036884
Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking.Q51906284
Involvement of nicotinic receptors in alcohol self-administration.Q52170503
Subjective responses to alcohol in sons of alcoholics and control subjects.Q52272959
The biological bases of nicotine and alcohol co-addiction.Q52290406
Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer.Q53964001
SAFTEE: a technique for the systematic assessment of side effects in clinical trialsQ69649764
Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatmentQ71865726
The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamineQ72723449
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotineQ28589593
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seekingQ30502320
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administrationQ33820862
Smoking status as a clinical indicator for alcohol misuse in US adultsQ33848797
Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trialQ33997418
Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanolQ34002764
Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinomaQ34554393
Neurochemical and behavioral studies on ethanol and nicotine interactionsQ35690515
Nicotine addiction and comorbidity with alcohol abuse and mental illnessQ36298360
Nicotine and non-nicotine smoking cessation pharmacotherapiesQ36403207
Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism.Q36764752
Alcohol's actions on neuronal nicotinic acetylcholine receptors.Q36764756
Cancer risk associated with alcohol and tobacco use: focus on upper aero-digestive tract and liver.Q36764761
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.Q38405712
Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.Q38407349
Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settingsQ39420790
Development and initial validation of a measure of drinking urges in abstinent alcoholicsQ39474611
Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbensQ41706616
Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexoneQ42454703
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis.Q43893915
Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcoholQ43940291
Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbensQ43940320
Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in miceQ44292703
A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefeneQ44374802
Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkersQ44453598
Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinkingQ44727564
Varenicline in the routine treatment of tobacco dependence: a pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illnessQ44834253
Mecamylamine and ethanol preference in healthy volunteersQ45227006
Age at smoking onset and its association with alcohol consumption and DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic SurveyQ45240544
The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine systemQ46173380
Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat.Q46618419
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectvareniclineQ411330
P304page(s)185-190
P577publication date2009-02-27
P1433published inBiological PsychiatryQ4914961
P1476titleVarenicline reduces alcohol self-administration in heavy-drinking smokers
P478volume66

Reverse relations

cites work (P2860)
Q33720707"Killing Two Birds with One Stone": Alcohol Use Reduction Interventions with Potential Efficacy in Enhancing Self-Control
Q54998102A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking.
Q34552358A Critical Review of the Effects of Nicotine and Alcohol Coadministration in Human Laboratory Studies
Q30412161A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence
Q34038943A human alcohol self-administration paradigm to model individual differences in impaired control over alcohol use.
Q36821304A preliminary investigation of varenicline for heavy drinking smokers
Q37602654A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self-administration
Q34137278Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption
Q34516895Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task
Q47182010Advances in Pharmacotherapy Development: Human Clinical Studies
Q34411076Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment
Q91994135Alcohol, tobacco, and marijuana consumption is associated with increased odds of same-day substance co- and tri-use
Q104460866An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study
Q38839642An overview of alcohol and tobacco/nicotine interactions in the human laboratory
Q36185892Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats
Q37698964Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults
Q41636544Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Q92189687Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future
Q36781037CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Q37259110Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats
Q36133717Cigarette smoking predicts differential benefit from naltrexone for alcohol dependence
Q38594528Clinical neuroscience of addiction: similarities and differences between alcohol and other drugs
Q34351761Cognitive control in alcohol use disorder: deficits and clinical relevance
Q34183988Cognitive enhancers in the treatment of substance use disorders: clinical evidence
Q35689017Combined varenicline and naltrexone treatment reduces smoking topography intensity in heavy-drinking smokers.
Q42149212Combining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism.
Q36372867Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
Q36877440Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers
Q41938714Developing a model of limited-access nicotine consumption in C57Bl/6J mice.
Q90308784Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice
Q52639267Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.
Q36936258Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders
Q47275723Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial
Q37059266Effect of Varenicline Combined with High-Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings
Q50042559Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study
Q36363819Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers
Q94155051Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome
Q36963775Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats
Q43121435Effects of systemic nicotine, alcohol or their combination on cholinergic markers in the frontal cortex and hippocampus of rat.
Q49892752Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats
Q38732866Effects of varenicline on alcohol cue reactivity in heavy drinkers
Q38870727Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Q48124586Effects of varenicline on cognitive performance in heavy drinkers: Dose-response effects and associations with drinking outcomes
Q41808636Effects of varenicline on ethanol- and food-maintained responding in a concurrent access procedure
Q34940888Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization
Q36319552Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse
Q35429740Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys
Q37766239Emerging drugs to treat alcoholism
Q33818913Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes
Q43195621Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: behavioral and electrophysiological findings.
Q38856407Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research
Q48666297Fatality following a suicidal overdose with varenicline
Q22242633Future pharmacological treatments for substance use disorders
Q36872261Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats
Q54205394Gene Editing Vectors for Studying Nicotinic Acetylcholine Receptors in Cholinergic Transmission.
Q34970821Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption
Q36231851Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision
Q30441131How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use?
Q34205530Human laboratory paradigms in alcohol research.
Q35124169Incremental efficacy of adding bupropion to the nicotine patch for smoking cessation in smokers with a recent history of alcohol dependence: results from a randomized, double-blind, placebo-controlled study
Q90566716Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial
Q62729760Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking
Q36724460Longitudinal associations between smoking cessation medications and alcohol consumption among smokers in the International Tobacco Control Four Country survey
Q28263028Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders
Q47667884Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Q30399710Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum
Q38718932Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models
Q47942161Medications for alcohol use disorders: An overview
Q58131549Missed opportunities to test the neuropsychiatric safety--and efficacy--of varenicline among smokers with substance use disorders
Q35911952Moderators of Varenicline Treatment Effects in a Double-Blind, Placebo-Controlled Trial for Alcohol Dependence: An Exploratory Analysis
Q30475871Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice
Q34383928Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration
Q52684297Muscarinic M5 receptors modulate ethanol seeking in rats.
Q35091293N-methyl-D-aspartate receptor antagonism has differential effects on alcohol craving and drinking in heavy drinkers
Q38768062Naltrexone for the treatment of comorbid tobacco and pornography addiction
Q34809762Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence
Q37473457Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders
Q34342747Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence
Q36137598Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions
Q37722622Nicotine administration in the cholinergic basal forebrain increases alcohol consumption in C57BL/6J mice.
Q47960292Nicotine administration in the wake-promoting basal forebrain attenuates sleep-promoting effects of alcohol
Q35034473Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors
Q24234860Nicotine receptor partial agonists for alcohol dependence
Q26472086Nicotine receptor partial agonists for alcohol dependence
Q52305793Nicotine-induced locomotor sensitization: pharmacological analyses with candidate smoking cessation aids.
Q35079043Nicotinic acetylcholine receptors containing the α4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption
Q35850223Nicotinic acetylcholine receptors containing the α4 subunit modulate alcohol reward
Q35591662Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward-related behaviours
Q28087047Nicotinic receptor modulation to treat alcohol and drug dependence
Q26853630Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation
Q27324817Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice
Q89402756Overcoming the "Valley of Death" in Medications Development for Alcohol Use Disorder
Q34661812Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats
Q28655227Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in rodents
Q36294656Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers
Q37708082Pharmacological approaches to reducing craving in patients with alcohol use disorders
Q36684437Pharmacotherapy for alcohol use disorder: current and emerging therapies
Q43061723Pharmacotherapy of alcoholism - an update on approved and off-label medications
Q42583506Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence
Q36039402Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review.
Q34359231Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system
Q51084128Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models.
Q92501996Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption
Q36581617Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism
Q41528453Relative potency of varenicline or fluvoxamine to reduce responding for ethanol versus food depends on the presence or absence of concurrently earned food
Q37400844Results from a pilot clinical trial of varenicline for the treatment of alcohol dependence
Q36821822Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers
Q28083649Risk of neuropsychiatric adverse events associated with varenicline: systematic review and meta-analysis
Q36342934Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research
Q37193626Rodent models for compulsive alcohol intake
Q28109507Role of appetite-regulating peptides in the pathophysiology of addiction: implications for pharmacotherapy
Q35690145Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders
Q33855987SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
Q58100058State-of-the-art behavioral and pharmacological treatments for alcohol use disorder
Q34079637Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking
Q38685941Subjective Response to Alcohol as a Research Domain Criterion.
Q99581955Suicide Attempt in a 38-Year-Old Patient on Varenicline While Intoxicated With Alcohol
Q37942053The CHRNA5-A3-B4 gene cluster in nicotine addiction
Q91796599The Cholinergic System as a Treatment Target for Opioid Use Disorder
Q48305886The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?
Q47442429The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers.
Q92297287The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory
Q47403081The Nicotinic α6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats
Q37401674The effect of smoking on allogeneic transplant outcomes.
Q37404736The effects of varenicline on alcohol seeking and self-administration in baboons.
Q36892785The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes
Q34336464The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice
Q47550611The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption
Q33949792The predicted impact of reducing the nicotine content in cigarettes on alcohol use
Q34959736The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity
Q35788371The role of varenicline on alcohol-primed self-administration and seeking behavior in rats
Q37514878The α5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice
Q30442195The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse
Q37043526Treatment of tobacco dependence in people with mental health and addictive disorders
Q48004085Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats.
Q39196596Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens
Q50235992Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats
Q38129470Varenicline and neuronal nicotinic acetylcholine receptors: a new approach to the treatment of co-occurring alcohol and nicotine addiction?
Q36687594Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons.
Q41862387Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control.
Q34271996Varenicline decreases alcohol consumption in heavy-drinking smokers
Q33929766Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens
Q43188062Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats.
Q34097966Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals
Q34190097Varenicline for tobacco dependence: panacea or plight?
Q50088319Varenicline for tobacco-dependence treatment in alcohol-dependent smokers: A randomized controlled trial
Q40491939Varenicline for treatment of alcohol dependence: a randomized, placebo-controlled trial
Q35219810Varenicline in the treatment of alcohol use disorders
Q47676125Varenicline modulates ethanol and saccharin consumption in adolescent male and female C57BL/6J mice
Q30454909Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements
Q88959955Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial
Q47373861Varenicline versus nicotine patch with brief advice for smokers with substance use disorders with or without depression: effects on smoking, substance use and depressive symptoms
Q35046256Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats
Q34167551Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings.
Q35195302Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings.
Q34157977Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study
Q36532722Α4β2 and α7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision-making tasks

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