TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent

scientific article

TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/MOL.111.073205
P932PMC publication ID3198916
P698PubMed publication ID21821734
P5875ResearchGate publication ID51552207

P50authorWon Joo ChoeQ42355498
Vesna Jevtovic-TodorovicQ60642341
Veit-Simon EckleQ88088249
P2093author name stringSlobodan M Todorovic
Reza Salajegheh
Aleksandar Obradovic
Emily Leach
Richard B Messinger
P2860cites workMolecular characterization of a neuronal low-voltage-activated T-type calcium channelQ24316054
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Molecular physiology of low-voltage-activated t-type calcium channelsQ28200827
Attenuated pain responses in mice lacking Ca(V)3.2 T-type channelsQ28260743
Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neuronsQ28342691
Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blockerQ30309941
Potent analgesic effects of anticonvulsants on peripheral thermal nociception in ratsQ30311218
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesiaQ30433597
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivoQ30434076
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob miceQ30434283
In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathyQ30434954
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors.Q30438110
The role of peripheral T-type calcium channels in pain transmissionQ30440753
Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neuronsQ30443224
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channelsQ30444180
Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H.Q30447500
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathwayQ30452208
Ion channels of nociception.Q33547278
Diabetic neuropathy: mechanisms to managementQ33554384
Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agentsQ34451739
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxinQ34464493
On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.Q34472682
Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.Q35688088
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.Q35824087
Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neuronsQ36295971
Pharmacology and drug discovery for T-type calcium channelsQ36683558
Towards the discovery of novel T-type calcium channel blockers.Q36804457
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.Q39671872
Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.Q40653150
Redox modulation of T-type calcium channels in rat peripheral nociceptorsQ40787127
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)windowQ40873132
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.Q40949695
Cloning and expression of a novel member of the low voltage-activated T-type calcium channel familyQ40969230
Properties of Ba2+ currents arising from human alpha1E and alpha1Ebeta3 constructs expressed in HEK293 cells: physiology, pharmacology, and comparison to native T-type Ba2+ currentsQ40991791
Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker.Q41711953
Reversal of experimental neuropathic pain by T-type calcium channel blockersQ44589954
Thalamic Control of Visceral Nociception Mediated by T-Type Ca 2+ ChannelsQ44606624
Rapid onset pain induced by intravenous streptozotocin in the ratQ44658686
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonistQ46550414
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activityQ48357310
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.Q48666040
Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic painQ48905791
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxinQ48921080
Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.Q49012811
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.Q51338352
Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants.Q51395959
Role of T-Type Calcium Current in Identified D-Hair Mechanoreceptor Neurons Studied In VitroQ56980269
Amiloride selectively blocks the low threshold (T) calcium channelQ69022800
Mechanisms of neuropathic painQ79173262
P433issue5
P304page(s)900-910
P577publication date2011-08-05
P1433published inMolecular PharmacologyQ1943386
P1476titleTTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent
P478volume80

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