AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia

scientific article published on February 2013

AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2012.02174.X
P8608Fatcat IDrelease_u5c35wzyjbfariihwbthef45l4
P932PMC publication ID3579291
P698PubMed publication ID22924591

P2093author name stringYuka Aoki
Atsufumi Kawabata
Fumiko Sekiguchi
Daiki Kanaoka
Maho Tsubota-Matsunami
Maiko Nakagawa
Rumi Yamanaka
Shigeru Yoshida
Yuta Nishimoto
P2860cites workSensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandinsQ24806526
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A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1Q28568896
Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150Q28572544
TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agentQ30424352
T-type voltage-gated calcium channels as targets for the development of novel pain therapiesQ30426595
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathwayQ30432705
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesiaQ30433597
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob miceQ30434283
Protein kinase A activity controls the regulation of T-type CaV3.2 channels by Gbetagamma dimersQ30436711
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Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in miceQ36166689
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neuronsQ37094339
A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1Q37438112
Prostaglandin E2 and pain--an updateQ37908918
Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface densityQ38508607
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Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptorsQ39791140
Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channelsQ39909142
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Temperature-dependent modulation of CaV3 T-type calcium channels by protein kinases C and A in mammalian cells.Q40081052
CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic propertiesQ40134215
Subunit-specific modulation of T-type calcium channels by zinc.Q40212704
Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line.Q40710712
Redox modulation of T-type calcium channels in rat peripheral nociceptorsQ40787127
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.Q40949695
The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociceptionQ41424078
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cellsQ42442156
Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.Q42501246
Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motilityQ42529103
Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.Q42946191
Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic painQ43024302
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory painQ43062599
Modulation of Ca2+ channel current by mu opioid receptors in prefrontal cortex pyramidal neurons in rats.Q44338364
Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexinQ44381194
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Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.Q46000821
Luminal hydrogen sulfide plays a pronociceptive role in mouse colonQ46318763
Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.Q46540769
Differential regulation of N- and Q-type Ca2+ channels by cyclic nucleotides and G-proteinsQ48941398
Augmentation of Cav3.2 T-type calcium channel activity by cAMP-dependent protein kinase A.Q50651224
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.Q53246817
Hydrogen sulfide as a novel nociceptive messenger.Q53566710
Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons.Q54612135
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoidQ80737904
Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channelsQ83482372
ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitisQ83595241
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)734-745
P577publication date2013-02-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia
P478volume168

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cites work (P2860)
Q92857474Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
Q42449128Nitric oxide suppresses vascular voltage-gated T-type Ca2+ channels through cGMP/PKG signaling
Q38075143T-type Ca²⁺ channels in cerebral arteries: approaches, hypotheses, and speculation.
Q51115110Tacrolimus Triggers Transient Receptor Potential Vanilloid-1-Dependent Relapse of Pancreatitis-Related Pain in Mice.

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