T-type voltage-gated calcium channels as targets for the development of novel pain therapies

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T-type voltage-gated calcium channels as targets for the development of novel pain therapies is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01256.X
P932PMC publication ID3101611
P698PubMed publication ID21306582
P5875ResearchGate publication ID49822341

P50authorVesna Jevtovic-TodorovicQ60642341
P2093author name stringSlobodan M Todorovic
P2860cites workMolecular characterization of a neuronal low-voltage-activated T-type calcium channelQ24316054
Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channelsQ24316197
Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene familyQ24316347
The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.Q24676565
Structure and regulation of voltage-gated Ca2+ channelsQ28141138
T-type calcium channel regulation by specific G-protein betagamma subunitsQ28186366
Molecular physiology of low-voltage-activated t-type calcium channelsQ28200827
Attenuated pain responses in mice lacking Ca(V)3.2 T-type channelsQ28260743
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system functionQ28289375
Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neuronsQ28342691
Stimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C)Q28345043
Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamideQ28366316
Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channelsQ28369869
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channelsQ28567108
Regulation of T-type calcium channels by Rho-associated kinaseQ28568889
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesiaQ28582696
Specific properties of T-type calcium channels generated by the human alpha 1I subunit.Q47872006
A comparison of the burst activity of lateral thalamic neurons in chronic pain and non-pain patientsQ48202046
Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neuronsQ48327297
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activityQ48357310
Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variationsQ48557743
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxinQ48921080
Differences in Ca2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II.Q51496112
Hydrogen sulfide as a novel nociceptive messenger.Q53566710
Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurons differentiated by membrane properties.Q54158540
Role of T-Type Calcium Current in Identified D-Hair Mechanoreceptor Neurons Studied In VitroQ56980269
Low- and high-voltage-activated calcium currents in rat spinal dorsal horn neuronsQ67655338
T-type calcium channels: heterogeneous expression in rat sensory neurons and selective modulation by phorbol estersQ68453576
GABAA-receptor-activated current in dorsal root ganglion neurons freshly isolated from adult ratsQ68473432
Amiloride selectively blocks the low threshold (T) calcium channelQ69022800
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuliQ71228225
Voltage-dependent calcium currents are enhanced in dorsal root ganglion neurones from the Bio Bred/Worchester diabetic ratQ71513386
Myelinated afferent fibres responding specifically to noxious stimulation of the skinQ72291143
Presynaptic receptorsQ74578161
Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglionQ79368090
Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamusQ82816941
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channelsQ30303630
Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1).Q30309951
A mechanism for the direct regulation of T-type calcium channels by Ca2+/calmodulin-dependent kinase II.Q30311927
Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channelsQ30433407
A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptorsQ30433450
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesiaQ30433597
Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathwayQ30433716
Functional impact of alternative splicing of human T-type Cav3.3 calcium channelsQ30433971
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivoQ30434076
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob miceQ30434283
In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathyQ30434954
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channelsQ30435619
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroidsQ30436316
Protein kinase A activity controls the regulation of T-type CaV3.2 channels by Gbetagamma dimersQ30436711
5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic painQ30437972
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors.Q30438110
Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerveQ30439844
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamusQ30440317
Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neuronsQ30443224
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channelsQ30444180
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbateQ30444989
Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H.Q30447500
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathwayQ30452208
A T-type calcium channel required for normal function of a mammalian mechanoreceptorQ33187408
The vanilloid receptor: a molecular gateway to the pain pathwayQ33941065
Specificity of cold thermotransduction is determined by differential ionic channel expressionQ34113463
Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells.Q34237255
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channelsQ34278287
Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropaneQ34292344
Low-threshold calcium spike bursts in the human thalamus. Common physiopathology for sensory, motor and limbic positive symptomsQ34396629
Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agentsQ34451739
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxinQ34464493
On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.Q34472682
Synaptic amplifier of inflammatory pain in the spinal dorsal hornQ34538726
Posttranslational mechanisms of peripheral sensitizationQ35884837
Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neuronsQ36295971
Mechanism of arachidonic acid modulation of the T-type Ca2+ channel alpha1GQ36445341
Pharmacology and drug discovery for T-type calcium channelsQ36683558
Towards the discovery of novel T-type calcium channel blockers.Q36804457
Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat.Q37352328
Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface densityQ38508607
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.Q39671872
Structural and biophysical determinants of single Ca(V)3.1 and Ca(V)3.2 T-type calcium channel inhibition by N(2)O.Q39794785
Temperature-dependent modulation of CaV3 T-type calcium channels by protein kinases C and A in mammalian cells.Q40081052
A selective T-type Ca2+ channel blocker R(-) efonidipineQ40123411
Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.Q40126566
Alternatively spliced alpha(1G) (Ca(V)3.1) intracellular loops promote specific T-type Ca(2+) channel gating properties.Q40179790
Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels.Q40205455
Subunit-specific modulation of T-type calcium channels by zinc.Q40212704
A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsiesQ40339373
Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidenceQ40485751
Expression of T-type calcium channel splice variants in human glioma.Q40513808
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channelsQ40600165
Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.Q40653150
Differential inhibition of T-type calcium channels by neuroleptics.Q40757971
Redox modulation of T-type calcium channels in rat peripheral nociceptorsQ40787127
Arachidonic acid modulation of alpha1H, a cloned human T-type calcium channelQ40904445
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.Q40949695
Cloning and expression of a novel member of the low voltage-activated T-type calcium channel familyQ40969230
Low-threshold calcium currents in central nervous system neurons.Q41117703
T-type Ca2+ channels and pharmacological blockade: potential pathophysiological relevanceQ41725880
Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma.Q42628548
Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.Q42946191
Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic painQ43024302
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.Q43257249
Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in ratsQ43557368
L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in miceQ43640188
Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathyQ43701685
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channelsQ43702724
Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxideQ43705779
Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neuronsQ44346268
Reversal of experimental neuropathic pain by T-type calcium channel blockersQ44589954
Thalamic Control of Visceral Nociception Mediated by T-Type Ca 2+ ChannelsQ44606624
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathyQ44843038
State-dependent mibefradil block of Na+ channelsQ45161630
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.Q46000821
Luminal hydrogen sulfide plays a pronociceptive role in mouse colonQ46318763
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonistQ46550414
Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different sizeQ46939264
Correlation of cell body size, axon size, and signal conduction velocity for individually labelled dorsal root ganglion cells in the cat.Q47213232
Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.Q47400321
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectvoltageQ25428
P304page(s)484-495
P577publication date2011-06-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleT-type voltage-gated calcium channels as targets for the development of novel pain therapies
P478volume163

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cites work (P2860)
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