Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

scientific article

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.401372
P8608Fatcat IDrelease_qbpktkub3velbodjmwjoz3wn5i
P932PMC publication ID3581406
P698PubMed publication ID23297410

P50authorJulijus BogomolovasQ30158959
Siegfried LabeitQ30159057
H.L. GranzierQ67484897
P2093author name stringBrian R Anderson
P2860cites workMutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathyQ24306039
Titins: giant proteins in charge of muscle ultrastructure and elasticityQ24312140
ModBase, a database of annotated comparative protein structure models, and associated resourcesQ24613729
Multiple sequence alignment with the Clustal series of programsQ24672842
Mechanical network in titin immunoglobulin from force distribution analysisQ27335952
A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chainQ27649593
Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticityQ27733375
Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratodermaQ28143046
Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineeringQ28203415
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitroQ28265173
Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathyQ28280387
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathyQ28288328
The Jpred 3 secondary structure prediction serverQ29547592
Stretching DNAQ30040484
Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.Q31078269
Mechanical unfolding intermediates in titin modules.Q31431985
Unfolding of titin immunoglobulin domains by steered molecular dynamics simulationQ32051091
Cardiovascular causes of sudden death in young individuals including athletesQ33698037
Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy studyQ33718324
Mechanical and chemical unfolding of a single protein: a comparisonQ33856547
Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).Q33910305
Order Statistics Theory of Unfolding of Multimeric ProteinsQ34134764
Truncations of titin causing dilated cardiomyopathy.Q34254460
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathyQ34331630
Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.Q34673137
Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tensionQ34688810
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromesQ35197101
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycleQ35224032
Titin-actin interaction: PEVK-actin-based viscosity in a large animalQ35582401
The giant protein titin: a major player in myocardial mechanics, signaling, and diseaseQ35672016
Atomic force microscopy reveals the mechanical design of a modular protein.Q35780683
Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segmentsQ36276684
Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequenceQ37281915
Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a not so rare "disease of the desmosome" with multiple clinical presentationsQ37389311
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffnessQ37394610
Titin-based mechanical signalling in normal and failing myocardiumQ37565374
Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatmentQ37670848
Cardiac titin: a multifunctional giantQ37755897
Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutationsQ41880757
Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.Q42445262
Poly-Ig tandems from I-band titin share extended domain arrangements irrespective of the distinct features of their modular constituentsQ46845764
Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial functionQ68105497
Point mutations alter the mechanical stability of immunoglobulin modulesQ73256929
Differential expression of cardiac titin isoforms and modulation of cellular stiffnessQ73333652
Quantitative determination of protein stability and ligand binding by pulse proteolysisQ81132673
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectheart diseaseQ190805
P304page(s)5303-5315
P577publication date2013-01-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleSingle molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism
P478volume288

Reverse relations

cites work (P2860)
Q36916032Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques
Q34407578Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Q52658660Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction.
Q30393558Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.
Q41880328Individual globular domains and domain unfolding visualized in overstretched titin molecules with atomic force microscopy
Q92858875Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity
Q30576327S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding
Q57374706Single-Molecule Force Spectroscopy Study on Modular Resilin Fusion Protein
Q91635522Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP
Q38699748The genetic basis of hypertrophic cardiomyopathy in cats and humans.
Q28246696Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy
Q92663455Titin mutations and muscle disease
Q64067919Unveiling the influence of device stiffness in single macromolecule unfolding
Q41478184Work Done by Titin Protein Folding Assists Muscle Contraction

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