| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2002PNAS...9915937F |
| P356 | DOI | 10.1073/PNAS.252640799 |
| P932 | PMC publication ID | 138543 |
| P698 | PubMed publication ID | 12461170 |
| P5875 | ResearchGate publication ID | 11009784 |
| P50 | author | Joseph Schlessinger | Q2908140 |
| Sarel J Fleishman | Q41625606 | ||
| Nir Ben-Tal | Q47333803 | ||
| P2860 | cites work | G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene | Q40507769 |
| A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling | Q40673334 | ||
| Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain | Q40782870 | ||
| Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation | Q42803794 | ||
| Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. | Q42811529 | ||
| The single transmembrane domains of ErbB receptors self-associate in cell membranes | Q43821697 | ||
| A point mutation in the neu oncogene mimics ligand induction of receptor aggregation | Q44611984 | ||
| Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. | Q52081092 | ||
| Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk. | Q53412908 | ||
| Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor | Q57103722 | ||
| A Novel Scoring Function for Predicting the Conformations of Tightly Packed Pairs of Transmembrane α-Helices | Q57207133 | ||
| Neu receptor dimerization | Q59087928 | ||
| A transmembrane helix dimer: structure and implications | Q27735013 | ||
| Cell signaling by receptor tyrosine kinases | Q27860474 | ||
| Signal transduction by receptors with tyrosine kinase activity | Q27860624 | ||
| Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices | Q28298420 | ||
| ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer | Q28678776 | ||
| The GxxxG motif: a framework for transmembrane helix-helix association | Q30839523 | ||
| Receptor signaling: when dimerization is not enough | Q33723925 | ||
| ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling | Q33886341 | ||
| A subdomain in the transmembrane domain is necessary for p185neu* activation | Q33937484 | ||
| The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification | Q34249785 | ||
| Helix to helix packing in proteins | Q34283185 | ||
| Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase | Q34769307 | ||
| Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene | Q36851389 | ||
| A sequence motif in the transmembrane region of growth factor receptors with tyrosine kinase activity mediates dimerization | Q37878779 | ||
| Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling | Q40015717 | ||
| An EcoRI polymorphism at the insulin receptor locus on a fragment comprising exons 4 to 8. | Q40507764 | ||
| P433 | issue | 25 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | transmembrane protein | Q424204 |
| P304 | page(s) | 15937-15940 | |
| P577 | publication date | 2002-12-02 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | A putative molecular-activation switch in the transmembrane domain of erbB2. | |
| P478 | volume | 99 |
| Q24810260 | A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer |
| Q37640954 | A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα-H hydrogen bonds. |
| Q92956374 | A lipophilicity-based energy function for membrane-protein modelling and design |
| Q47757344 | A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion |
| Q46139248 | A simple method for modeling transmembrane helix oligomers |
| Q37189482 | A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor |
| Q79103480 | A single nucleotide polymorphism in the transmembrane domain coding region of HER‐2 is associated with development and malignant phenotype of gastric cancer |
| Q35674768 | A structural perspective on the regulation of the epidermal growth factor receptor |
| Q93198405 | Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations |
| Q34488179 | Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model". |
| Q54310876 | Allosteric targeting of receptor tyrosine kinases. |
| Q30955555 | An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data |
| Q36923502 | Architecture and membrane interactions of the EGF receptor |
| Q53241143 | Association between the HER2 Ile655Val polymorphism and response to trastuzumab in women with operable primary breast cancer. |
| Q40212670 | Association of HER2 codon 655 polymorphism with ovarian cancer |
| Q31044283 | Association of transmembrane helices: what determines assembling of a dimer? |
| Q27680399 | Binding of MgtR, a Salmonella Transmembrane Regulatory Peptide, to MgtC, a Mycobacterium tuberculosis Virulence Factor: A Structural Study |
| Q47857232 | Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles |
| Q24797594 | Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study |
| Q98771763 | Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains |
| Q27336007 | Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations |
| Q24313122 | Conformational coupling across the plasma membrane in activation of the EGF receptor |
| Q43466172 | Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial |
| Q47877355 | Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer |
| Q35997942 | Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study |
| Q41842705 | Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation. |
| Q58112780 | Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands |
| Q42652187 | Direct resequencing of the complete ERBB2 coding sequence reveals an absence of activating mutations in ERBB2 amplified breast cancer |
| Q38101685 | Does mammographic density reflect the expression of breast cancer markers? |
| Q37263733 | Energetics of ErbB1 transmembrane domain dimerization in lipid bilayers |
| Q90886378 | Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics |
| Q24303562 | ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers |
| Q54694061 | Fast detection of single nucleotide polymorphisms (SNPs) by primer elongation with monitoring of supercritical-angle fluorescence. |
| Q46504860 | Focus on ERBB2. |
| Q34500998 | Functional Polymorphisms Associated with Disease-Free Survival in Resected Carcinoma of the Esophagus |
| Q90393213 | Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab |
| Q35342149 | GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors |
| Q36660906 | HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer |
| Q50125137 | HER2 Ile655Val polymorphism is negatively associated with breast cancer susceptibility. |
| Q33686182 | HER2 Pro1170Ala polymorphism is associated with decreased survival rate in HER2-negative breast cancer |
| Q35749374 | HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks |
| Q54111164 | Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies. |
| Q45252441 | Her2 genotype and breast cancer progression in Korean women |
| Q26741039 | Homeoviscous Adaptation and the Regulation of Membrane Lipids |
| Q34028470 | Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib |
| Q80951655 | Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search |
| Q37520862 | Interaction and conformational dynamics of membrane-spanning protein helices |
| Q27660088 | Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine Kinases |
| Q41872323 | Lipid-modulated sequence-specific association of glycophorin A in membranes |
| Q24309071 | Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment |
| Q35118815 | Mechanisms of integral membrane protein insertion and folding |
| Q28541111 | Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor |
| Q36993693 | Molecular basis for multimerization in the activation of the epidermal growth factor receptor |
| Q80657737 | Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly |
| Q40316579 | Molecular modeling of nearly full-length ErbB2 receptor. |
| Q38911211 | Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane |
| Q35378448 | N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes |
| Q37532615 | Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. |
| Q35414389 | Oncogenic HER2 fusions in gastric cancer |
| Q51143792 | PREDDIMER: a web server for prediction of transmembrane helical dimers. |
| Q35762279 | Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation |
| Q37917164 | Physical-chemical principles underlying RTK activation, and their implications for human disease |
| Q39886331 | Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase. |
| Q50949600 | Polymorphism and overexpression of HER2/neu among ovarian carcinoma women from Tiruchirapalli, Tamil Nadu, India. |
| Q43767305 | Polymorphisms of ERBB2 and breast cancer risk: a meta-analysis of 26 studies involving 35,088 subjects |
| Q36569264 | Prediction, refinement, and persistency of transmembrane helix dimers in lipid bilayers using implicit and explicit solvent/lipid representations: microsecond molecular dynamics simulations of ErbB1/B2 and EphA1. |
| Q37694979 | Receptor tyrosine kinase transmembrane domains: Function, dimer structure and dimerization energetics |
| Q37240717 | Reciprocal regulation of Abl and receptor tyrosine kinases |
| Q35597077 | Regulation of the catalytic activity of the EGF receptor. |
| Q34525985 | Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies |
| Q41151906 | Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer |
| Q35865954 | Sequence variants and haplotype analysis of cat ERBB2 gene: a survey on spontaneous cat mammary neoplastic and non-neoplastic lesions. |
| Q47382128 | Size and conformational features of ErbB2 and ErbB3 receptors: a TEM and DLS comparative study |
| Q91637215 | Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer |
| Q27651810 | Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1 |
| Q41855047 | Strong dimerization of wild-type ErbB2/Neu transmembrane domain and the oncogenic Val664Glu mutant in mammalian plasma membranes |
| Q33977508 | Structure elucidation of dimeric transmembrane domains of bitopic proteins |
| Q38606067 | Systems biology approaches to adverse drug effects: the example of cardio-oncology |
| Q26849417 | Ten things you should know about protein kinases: IUPHAR Review 14 |
| Q37360070 | The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency. |
| Q61809814 | The Effect of Single Nucleotide Polymorphisms on Cervical Cancer Susceptibility and Survival in a Chinese Population |
| Q55274551 | The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling. |
| Q42917676 | The effect of hydrophilic substitutions and anionic lipids upon the transverse positioning of the transmembrane helix of the ErbB2 (neu) protein incorporated into model membrane vesicles |
| Q33389608 | The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population |
| Q34493341 | The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis |
| Q34054213 | The role of HER2 in cancer therapy and targeted drug delivery |
| Q35729931 | The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function |
| Q44936803 | The transmembrane domain of Neu in a lipid bilayer: molecular dynamics simulations |
| Q26865109 | Transmembrane helix dimerization: beyond the search for sequence motifs |
| Q37704902 | Transmembrane helix-helix interactions involved in ErbB receptor signaling. |
| Q28539091 | Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations |
| Q30389866 | Understanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing? |
| Q36791927 | VEGFR-2 conformational switch in response to ligand binding. |
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