Joseph Schlessinger

American biochemist

DBpedia resource is: http://dbpedia.org/resource/Joseph_Schlessinger

Abstract is: Joseph Schlessinger (born Josip Schlessinger; 26 March 1945) is a Yugoslav-born Israeli-American biochemist and biophysician. He is chair of the Pharmacology Department at Yale University School of Medicine in New Haven, Connecticut, as well as the founding director of the school's new Cancer Biology Institute. His area of research is signaling through tyrosine phosphorylation, which is important in many areas of cellular regulation, especially growth control and cancer. Schlessinger's work has led to an understanding of the mechanism of transmembrane signaling by receptor tyrosine kinases and how the resulting signals control cell growth and differentiation.

Born 1945-03-26 in Topusko (Q2457438)

Joseph Schlessinger is …
instance of (P31):
humanQ5

External links are
P2381Academic Tree ID22571
P268Bibliothèque nationale de France ID16957283b
P8179Canadiana Name Authority IDncf11652500
P11496CiNii Research ID1140282266684825216
P646Freebase ID/m/03clkd7
P213ISNI0000000022250773
P8189J9U ID987009748011205171
P244Library of Congress authority IDn00122476
P2798Loop ID21321
P271NACSIS-CAT author IDDA09440647
P5380National Academy of Sciences member ID3009519
P856official websitehttp://www.med.yale.edu/pharm/chairman/biography.htm
P496ORCID iD0000-0002-5085-5969
P3368Prabook ID70807
P5504RISM IDpeople/30033006
P214VIAF ID8625880
P10832WorldCat Entities IDE39PBJw8Yt3xVymYPF3qjkrjG3

P512academic degreeDoctor of PhilosophyQ752297
P166award receivedDan David PrizeQ1158951
Keith R. Porter LectureQ1738081
BBVA Foundation Frontiers of Knowledge AwardQ6085042
Novartis-Drew AwardQ5119206
EMBO MembershipQ26268243
J. Allyn Taylor International Prize in MedicineQ56072830
Fellow of the AACR AcademyQ61636373
P27country of citizenshipUnited States of AmericaQ30
IsraelQ801
P69educated atMassachusetts Institute of TechnologyQ49108
Hebrew University of JerusalemQ174158
P108employerNew York UniversityQ49210
Yale UniversityQ49112
P734family nameSchlessingerQ7431702
SchlessingerQ7431702
SchlessingerQ7431702
P101field of workbiochemistryQ7094
biophysicsQ7100
P735given nameJosephQ471788
JosephQ471788
P463member ofAmerican Academy of Arts and SciencesQ463303
National Academy of SciencesQ270794
P1559name in native languageJoseph "Josip" Schlessinger
P106occupationchemistQ593644
researcherQ1650915
biochemistQ2919046
P21sex or gendermaleQ6581097
P937work locationWeizmann Institute of ScienceQ4182

Reverse relations

author (P50)
Q46847122'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages
Q28204617A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
Q31145317A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Q28272683A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases
Q28609913A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
Q41091475A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction
Q30476898A putative molecular-activation switch in the transmembrane domain of erbB2.
Q24312845A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
Q35730035A structure-based model for ligand binding and dimerization of EGF receptors
Q24310428A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
Q35227172Activation and regulation of the insulin receptor kinase
Q24323778Activation of Pyk2 by stress signals and coupling with JNK signaling pathway
Q36530938Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity
Q41063499Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.
Q30176542Activation of the JNK pathway is essential for transformation by the Met oncogene
Q30159764Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli
Q42069677Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase
Q50097689Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.
Q28626012All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor
Q44111116All signaling is local?
Q34812867Aryl Extensions of Thienopyrimidinones as Fibroblast Growth Factor Receptor 1 Kinase Inhibitors
Q24298413Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
Q34113008Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases
Q36435120Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions
Q46968375Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
Q41758716Autoregulatory mechanisms in protein-tyrosine kinases
Q30194769BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
Q41092861Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites
Q36251141Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region
Q29616451Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
Q24598357Cell signaling by receptor tyrosine kinases
Q24597152Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Q24302929Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
Q45165242Common and distinct elements in cellular signaling via EGF and FGF receptors
Q73924701Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain
Q24317755Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin
Q36693847Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
Q28574537Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways
Q27730747Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin
Q24290400Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
Q33889677Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
Q27620743Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta
Q27654624Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Q22254157Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
Q40819546Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors
Q28602870Data publication with the structural biology data grid supports live analysis
Q36119294Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice
Q112700471Design of protein-binding proteins from the target structure alone
Q34390266Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities
Q27658996Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Q27659340Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening
Q24652600Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Q37200035Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition
Q36646666Early and multiple origins of metastatic lineages within primary tumors
Q24529941Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
Q28143349Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src
Q42025518Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells
Q37028299Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
Q24607661Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Q35549802FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis
Q103802263FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho
Q39855504FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma
Q24531227FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Q34314559FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
Q34373879FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells
Q24306912Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro
Q24611910GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
Q41739529Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity
Q29618315Growth factor signaling by receptor tyrosine kinases
Q54295628Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
Q54246457Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
Q24305821Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
Q24554522Identification of a new Pyk2 target protein with Arf-GAP activity
Q22008764Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein
Q24308600Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
Q54246428Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity
Q47652834Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Q41024344Improved survival of patients with hypermutation in uterine serous carcinoma
Q24306449Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2
Q57947452Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1
Q36238299Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration
Q24305380Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
Q59079619Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes
Q67916386Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors
Q33584471Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae
Q38307028Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
Q50938192JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules
Q41092869Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites
Q28637863Kit receptor dimerization is driven by bivalent binding of stem cell factor
Q39807619Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway
Q36637663Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
Q28646134Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
Q37161750Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms
Q24306895Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal
Q112575182Mechanism for the activation of the anaplastic lymphoma kinase receptor
Q41846083Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants
Q37379877Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition
Q39746901Mutations in different components of FGF signaling in LADD syndrome
Q27632592Novel recognition mode between Vav and Grb2 SH3 domains
Q54215704Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.
Q36612419Nuclear signaling by receptor tyrosine kinases: the first robin of spring
Q34595942On the nature of low- and high-affinity EGF receptors on living cells
Q57270016PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation
Q40996433PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface
Q40023501Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.
Q42806503Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
Q38326603Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
Q28286087Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells
Q30195382Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor
Q34136306Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate
Q24307776Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions
Q28610859Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
Q35640945Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection
Q27675701RAC1P29S is a spontaneously activating cancer-associated GTPase
Q30540520Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development
Q38193038Receptor tyrosine kinases: legacy of the first two decades
Q41360988Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis
Q37470078Regression of Chemotherapy-Resistant Polymerase ε (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab
Q40922726Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?
Q40592846Regulation of signal transduction and signal diversity by receptor oligomerization
Q57044276Reminiscences on the "Classic" 1976 FRAP Article in Biophysical Journal
Q57947494Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases
Q35178872SH2 and PTB domains in tyrosine kinase signaling
Q30195496SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma
Q41756065SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
Q103802284Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association
Q37144170Scanning electron microscopy of cells and tissues under fully hydrated conditions
Q54003856Scratching the surface with the PH domain.
Q42832582Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells
Q57270013Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain
Q58450633Signal Transduction by Epidermal Growth Factor Receptor
Q27860624Signal transduction by receptors with tyrosine kinase activity
Q24598414Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes
Q44429540Signal transduction. Autoinhibition control
Q35676722Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.
Q30168465Solution structure of Grb2 reveals extensive flexibility necessary for target recognition
Q34736828Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy
Q27618450Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide
Q77813531Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide
Q39731307Spatial control of EGF receptor activation by reversible dimerization on living cells
Q33777007Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
Q24314456Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
Q42613837Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells
Q38309484Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond
Q55045564Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.
Q22010544Structural basis for FGF receptor dimerization and activation
Q27680371Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region
Q24323270Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
Q27649204Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation
Q28296195Structural basis for the activity of drugs that inhibit phosphodiesterases
Q46702120Structural biology of receptor tyrosine kinase kit
Q36463372Structural diversity and binding of FGF receptors
Q27733279Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
Q27732194Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
Q37571141Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers
Q50001768Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling
Q35849511Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
Q36793907The Dark Side of Cell Signaling: Positive Roles for Negative Regulators
Q38201344The EGFR family: not so prototypical receptor tyrosine kinases
Q35926480The biochemical response of the heart to hypertension and exercise
Q37635718The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation
Q28609622The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
Q35140672The docking protein FRS2α is a critical regulator of VEGF receptors signaling
Q41296343The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway
Q24799816The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
Q72658016The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system
Q42545786The genesis of Zelboraf: targeting mutant B-Raf in melanoma
Q24307577The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
Q37370492The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations
Q40949624The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases
Q24322529The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
Q38600953The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer
Q35729931The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function
Q54246424Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif
Q48145602Tony Pawson (1952-2013).
Q34245285Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains
Q47835044Transmembrane signaling by receptor oligomerization
Q41718624Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.
Q33885990Two EGF molecules contribute additively to stabilization of the EGFR dimer
Q24311075Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor
Q27673339Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
Q24669865Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling
Q24336399Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

Q7204909Plexxikonfounded byP112

The articles in Wikimedia projects and languages

azbجوزف شلسینقرwikipedia
      Joseph Schlessingerwikipedia
      Joseph Schlessingerwikipedia
Persian (fa / Q9168)جوزف شسیلینگرwikipedia
      יוסף שלזינגרwikipedia
      Joseph Schlessingerwikipedia
      Шлессингер, Джозефwikipedia

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