The genesis of Zelboraf: targeting mutant B-Raf in melanoma

scientific article published on October 2012

The genesis of Zelboraf: targeting mutant B-Raf in melanoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.201205167
P932PMC publication ID3461519
P698PubMed publication ID23027900
P5875ResearchGate publication ID231742521

P50authorJoseph SchlessingerQ2908140
P2093author name stringMatthew J Davis
P2860cites workThe protein kinase complement of the human genomeQ24324497
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalingQ24337017
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibQ24594790
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirusQ24595462
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
A census of human cancer genesQ24647081
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activityQ24652600
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profilingQ27851628
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Mutations of the BRAF gene in human cancerQ27860760
Sorafenib in advanced clear-cell renal-cell carcinomaQ28282767
Characterization of murine A-raf, a new oncogene related to the v-raf oncogeneQ28592226
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
MAP kinase signalling pathways in cancerQ29615542
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)Q29620033
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug designQ31145317
MAP kinase pathwaysQ33650641
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapyQ35920288
Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistanceQ36489360
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsQ37048053
B-raf, a new member of the raf family, is activated by DNA rearrangementQ40650163
Molecular cloning of the avian acute transforming retrovirus MH2 reveals a novel cell-derived sequence (v-mil) in addition to the myc oncogeneQ41466238
BRAFMutation in Metastatic Colorectal CancerQ61481269
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)15-19
P577publication date2012-10-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe genesis of Zelboraf: targeting mutant B-Raf in melanoma
P478volume199

Reverse relations

cites work (P2860)
Q41906937Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Q42545907Cell biology: at the center of modern biomedicine
Q42095882Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth
Q35033532Extracellular metabolic energetics can promote cancer progression

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