Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial

scientific article published on 19 June 2013

Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1006849305
P356DOI10.1007/S10549-013-2587-X
P698PubMed publication ID23780683
P5875ResearchGate publication ID239948249

P2093author name stringFrédérique Penault-Llorca
Patricia de Cremoux
Lise Roca
Véronique Diéras
Pierre Kerbrat
Henri Roché
Marc Spielmann
Anne-Laure Martin
Jean-Luc Canon
Laurent Cany
Jérôme Lemonnier
Emmanuelle Lappartient
Christel Mesleard
Stéphanie Chieze
P2860cites workLigand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941Q24321567
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study groupQ27824835
ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapyQ27851876
Molecular portraits of human breast tumoursQ28032461
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Trastuzumab-related cardiotoxicity: calling into question the concept of reversibilityQ28239961
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
A putative molecular-activation switch in the transmembrane domain of erbB2.Q30476898
Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomizedQ31089499
First-line trastuzumab plus epirubicin and cyclophosphamide therapy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: cardiac safety and efficacy data from the Herceptin, Cyclophosphamide, and Epirubicin (HQ33533553
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.Q33964848
Overexpression of class III beta tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy.Q34428153
Gene-expression signatures in breast cancerQ34948421
Adjuvant trastuzumab in HER2-positive breast cancerQ35710898
Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy aloneQ36006440
Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?Q36613598
Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patientsQ37292031
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune diseaseQ37371654
Interindividual variability of response to rituximab: from biological origins to individualized therapiesQ37826285
Gene expression profiling in breast cancer: classification, prognostication, and predictionQ37958156
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.Q40001571
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphomaQ40562102
Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial.Q42626922
The neu oncogene encodes an epidermal growth factor receptor-related proteinQ42812960
A multicenter randomized phase II study of sequential epirubicin/cyclophosphamide followed by docetaxel with or without celecoxib or trastuzumab according to HER2 status, as primary chemotherapy for localized invasive breast cancer patientsQ43060768
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallQ43180234
Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trialQ43241014
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer TrialQ43250043
Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cellsQ43760313
Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19,341 subjectsQ44179953
Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms.Q44239907
Identification and characterization of buried unpaired cysteines in a recombinant monoclonal IgG1 antibodyQ45396762
FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.Q45949257
Pre-operative systemic (neo-adjuvant) therapy with trastuzumab and docetaxel for HER2-overexpressing stage II or III breast cancer: results of a multicenter phase II trialQ46839548
Lack of replication for the association between HER2 I655V polymorphism and breast cancer risk: a systematic review and meta-analysis.Q51716563
Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.Q53412908
FcγR2A and 3A polymorphisms predict clinical outcome of trastuzumab in both neoadjuvant and metastatic settings in patients with HER2-positive breast cancerQ54630456
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)789-800
P577publication date2013-06-19
P1433published inBreast Cancer Research and TreatmentQ326085
P1476titleCorrelation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial
P478volume139

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cites work (P2860)
Q36139709Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.
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Q36413979FCGR2A, FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal cancer
Q57466758Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer
Q51816225Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial.
Q54111164Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies.
Q89802710Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity
Q37709365IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).
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Q38358816Pharmacogenetics and breast cancer management: current status and perspectives
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Q39163356Trastuzumab-associated cardiac events in the Persephone trial

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