IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).

scientific article

IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.13159
P932PMC publication ID5356837
P698PubMed publication ID27835865

P50authorFalk NimmerjahnQ1394084
Gero BrockhoffQ50638431
P2093author name stringFlorian Weber
Alexander Kroemer
Olaf Ortmann
Gero Brockhoff
Anja K Wege
P2860cites workImmunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.Q40001571
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Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancerQ40073275
Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistanceQ40109415
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Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphomaQ40562102
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Phenotypic and functional separation of memory and effector human CD8+ T cellsQ42951823
Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trialQ43466172
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trialQ43951696
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.Q46117208
Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: a pilot study.Q47766707
CD27 defines phenotypically and functionally different human NK cell subsetsQ49167535
Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2Q62604205
Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2Q62604209
ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapyQ27851876
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancerQ33418729
Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patientsQ33644305
Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivoQ33760403
Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activityQ34016504
Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotypeQ34434169
Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man?Q35906275
IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.Q35979037
Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguityQ36014411
Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.Q36139709
Resistance to Trastuzumab in Breast Cancer.Q36318226
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptorQ36363861
Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?Q36613598
Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapyQ36646476
Correlation between NK function and response to trastuzumab in metastatic breast cancer patientsQ36702442
IL-15 trans-presentation promotes human NK cell development and differentiation in vivoQ37061837
Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patientsQ37292031
Safety and immunologic effects of IL-15 administration in nonhuman primatesQ37352474
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune diseaseQ37371654
Regulatory T cells and breast cancer: implications for immunopathogenesisQ37787092
Activity and resistance of trastuzumab according to different clinical settings.Q37897395
The immune system and response to HER2-targeted treatment in breast cancerQ38183569
Natural and therapy-induced immunosurveillance in breast cancerQ38601420
CD44 expression contributes to trastuzumab resistance in HER2-positive breast cancer cells.Q38875316
Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophagesQ38896842
Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxideQ39456593
Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific growth factorsQ39501392
Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapyQ39547654
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibodyQ39705098
Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1.Q39901596
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)2731-2744
P577publication date2016-11-07
P1433published inOncotargetQ1573155
P1476titleIL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).
P478volume8

Reverse relations

cites work (P2860)
Q47277628Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Q40049630Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent
Q47156322Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy.

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