Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy.

scientific article published on 13 November 2017

Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy. is …
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scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2017.01544
P932PMC publication ID5694168
P698PubMed publication ID29181007

P50authorMariona CaboQ59548556
Federico RojoQ61766016
Miguel López-BotetQ46153132
Aura MuntasellQ46153170
P2093author name stringAna Rovira
Joan Albanell
Ignasi Tusquets
Sonia Servitja
María Martínez-García
P2860cites workCD56(dim)CD16(+) NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinasesQ79656747
Augmented HER-2 specific immunity during treatment with trastuzumab and chemotherapyQ81038993
Trastuzumab in the treatment of breast cancerQ81374982
Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillanceQ82193347
HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patientsQ82347187
Lapatinib enhances herceptin-mediated antibody-dependent cellular cytotoxicity by up-regulation of cell surface HER2 expressionQ84830887
Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cellsQ87674205
Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cellsQ24293644
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating moleculeQ24314704
Tumor-associated MICA is shed by ADAM proteasesQ24320055
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'Q24632192
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicityQ24651041
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cellsQ24675226
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicityQ24676938
Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancerQ24801183
NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?Q26746478
Newtonian cell interactions shape natural killer cell educationQ26797240
Adaptive Immune Resistance: How Cancer Protects from Immune AttackQ26798448
Interleukin 12: still a promising candidate for tumor immunotherapy?Q26861559
Trial Watch: Immunogenic cell death inducers for anticancer chemotherapyQ27004011
NK cells in the tumor microenvironmentQ27692606
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trialQ27851705
Association studies of Fcγ receptor polymorphisms with outcome in HER2+ breast cancer patients treated with trastuzumab in NCCTG (Alliance) Trial N9831Q27853035
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
NKG2D Ligands in Tumor Immunity: Two Sides of a CoinQ28083832
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyQ28088784
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cellsQ28145125
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancerQ28198153
KIR: diverse, rapidly evolving receptors of innate and adaptive immunityQ28203441
Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapyQ28235277
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response elementQ28508930
The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functionsQ28589215
Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor LigandsQ28972540
Fcgamma receptors as regulators of immune responsesQ29615584
Up on the tightrope: natural killer cell activation and inhibitionQ29619175
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humansQ33292180
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cellsQ33292289
Stromal gene expression predicts clinical outcome in breast cancerQ33330931
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancerQ33418729
Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trialQ33441996
Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast CancerQ33712476
Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort studyQ33739253
HLA-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared to HLA-Bw4-T-80 and HLA-A-Bw4 Isoforms in Rituximab or Dinutuximab-Based Cancer ImmunotherapyQ33785744
Targeting CD137 enhances the efficacy of cetuximab.Q33872482
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general populationQ33928216
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunityQ34073138
Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cellsQ34149109
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.Q34178128
Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancerQ34270064
Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune responseQ34314259
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancerQ34334333
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcomaQ37687323
IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).Q37709365
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell deathQ38011488
Combination strategies to enhance antitumor ADCC.Q38014085
Activating natural cytotoxicity receptors of natural killer cells in cancer and infectionQ38082002
Molecular determinants of trastuzumab efficacy: What is their clinical relevance?Q38096651
Cancer immunosurveillance and immunoediting by natural killer cellsQ38165687
The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.Q38178966
The immune system and response to HER2-targeted treatment in breast cancerQ38183569
Human NK cell response to pathogensQ38192286
Effect of tumor cells and tumor microenvironment on NK-cell function.Q38207947
Upmodulation by estrogen of HLA class I expression in breast tumor cell linesQ38312412
CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cellsQ38323397
Nectins and nectin-like molecules in development and diseaseQ38367019
Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2-Positive Breast Cancer: Analysis of the NSABP B-31 Trial.Q38385131
NK Cells and Cancer ImmunoeditingQ38508211
Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions.Q38542034
Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector FunctionsQ38542213
Human KIR repertoires: shaped by genetic diversity and evolutionQ38568881
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.Q38576510
Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells.Q38619194
Clinical relevance of host immunity in breast cancer: from TILs to the clinicQ38669465
Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing ParticlesQ38718440
Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T CellsQ38805640
Targeting natural killer cells in cancer immunotherapyQ38829849
NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.Q38852424
Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus.Q38911174
The genomic landscape of breast cancer and its interaction with host immunityQ38915694
Molecular Pathways: Targeting CD96 and TIGIT for Cancer ImmunotherapyQ38952555
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.Q39000284
PD-L1 expression and tumor infiltrating PD-1+ lymphocytes associated with outcome in HER2+ breast cancer patientsQ39036924
Targeting NK-cell checkpoints for cancer immunotherapyQ39150423
Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation.Q39162642
Type I Interferons and Natural Killer Cell Regulation in CancerQ39241784
Activation, coactivation, and costimulation of resting human natural killer cellsQ36652166
Taking license with natural killer cell maturation and repertoire developmentQ36652192
IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ productionQ36671364
Correlation between NK function and response to trastuzumab in metastatic breast cancer patientsQ36702442
Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition.Q36729376
Antibodies, Fc receptors and cancerQ36732841
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodiesQ36787500
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patientsQ36806268
NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17).Q36814614
Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion.Q36821168
Epirubicin pretreatment enhances NK cell-mediated cytotoxicity against breast cancer cells in vitroQ36841139
Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?Q36927830
IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomasQ37085973
Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer.Q37224577
Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patientsQ37292031
KIR Genes and Their Ligands Predict the Response to Anti-EGFR Monoclonal Antibodies in Solid Tumors.Q37471733
Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.Q48263702
Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade.Q50908445
PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors.Q51053344
First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors.Q51170722
E-cadherin expression in estrogen receptor-positive and negative breast carcinomas of postmenopausal women.Q53333139
Semiquantitative hormone receptor level influences response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancerQ54631094
Subtype-Specific Metagene-Based Prediction of Outcome after Neoadjuvant and Adjuvant Treatment in Breast Cancer.Q55041652
Imprint of human cytomegalovirus infection on the NK cell receptor repertoireQ56169020
Soluble MICA in malignant diseasesQ57257239
Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2Q62604205
Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2Q62604209
A HLA class I cis-regulatory element whose activity can be modulated by hormonesQ72804306
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumorsQ73400031
Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicityQ78469598
Regulation of perforin‐independent NK cell‐mediated cytotoxicityQ79092479
HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell linesQ39402352
Human breast tumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated and DNAM-mediated NK cell recognitionQ39470152
Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft modelsQ39519148
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumorsQ39546314
E-cadherin expression on human carcinoma cell affects trastuzumab-mediated antibody-dependent cellular cytotoxicity through killer cell lectin-like receptor G1 on natural killer cellsQ39579131
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRsQ39624540
Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with MyelomaQ39679967
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibodyQ39705098
CIS is a potent checkpoint in NK cell-mediated tumor immunityQ39744193
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor modelsQ39771295
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicityQ39908130
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.Q40001571
Control of Metastasis by NK CellsQ40092674
Human NK cell education by inhibitory receptors for MHC class I.Q40244934
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cellsQ40333010
Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.Q40425776
DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL inductionQ40446320
Paclitaxel probably enhances cytotoxicity of natural killer cells against breast carcinoma cells by increasing perforin production.Q40481593
A comparison of the in vitro and in vivo activities of IgG and F(ab')2 fragments of a mixture of three monoclonal anti-Her-2 antibodiesQ40552147
Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytesQ40568569
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.Q40616262
Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterizationQ40627446
Improved Survival of HER2+ Breast Cancer Patients Treated with Trastuzumab and Chemotherapy Is Associated with Host Antibody Immunity against the HER2 Intracellular DomainQ40745788
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor PromotionQ40912349
Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.Q40967373
Clinical significance of novel costimulatory molecule B7-H6 in human breast cancerQ41144481
Clinicopathologic Significance of the Intratumoral Heterogeneity of HER2 Gene Amplification in HER2-Positive Breast Cancer Patients Treated With Adjuvant TrastuzumabQ41344399
Serial killing of tumor cells by human natural killer cells--enhancement by therapeutic antibodiesQ41858652
IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced FunctionQ42134875
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapyQ42182888
Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linkerQ42221543
NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirusQ42270076
A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myelomaQ42609665
VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC.Q42723314
HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.Q42832247
ADAM10 and ADAM17: New players in trastuzumab tesistance.Q43106106
Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment.Q43185293
Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper functionQ43442797
Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cellsQ43760313
Classification of human natural killer cells based on migration behavior and cytotoxic response.Q44652404
Cellular immunity in breast cancer patients completing taxane treatmentQ44909385
Peripheral blood NK cells from breast cancer patients are tumor-induced composite subsets.Q45344093
HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic miceQ45736903
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.Q46108181
Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: a pilot study.Q47766707
Regulation of interferon-gamma production by IL-12 and IL-18.Q47933801
A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignanciesQ34376968
A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumabQ34382125
Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotypeQ34434169
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisQ34493341
Recognition of tumors by the innate immune system and natural killer cellsQ34496462
Natural killer cell memory in infection, inflammation and cancerQ34510646
Helper activity of natural killer cells during the dendritic cell-mediated induction of melanoma-specific cytotoxic T cellsQ34672927
Targeting the function of the HER2 oncogene in human cancer therapeuticsQ34766486
IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cellsQ34798580
Natural killer cells and dendritic cells: rendezvous in abused tissuesQ35014074
Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial.Q35102480
HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresiaQ35126397
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?Q35206311
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunityQ35208414
Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.Q35437978
Unravelling natural killer cell function: triggering and inhibitory human NK receptorsQ35611389
Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal EffectQ35639002
The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape.Q35740186
Prognostic and predictive value of PDL1 expression in breast cancerQ35741710
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancerQ35780315
Improved Natural Killer cell activity and retained anti-tumor CD8(+) T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapyQ35789363
Anti-HER2 CD4(+) T-helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancerQ35807188
Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding propertiesQ35889630
Mechanisms of resistance to TRAIL-induced apoptosis in cancerQ35954258
MHC class I molecules and KIRs in human history, health and survivalQ36047157
Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implicationsQ36088788
Progressive loss of anti-HER2 CD4(+) T-helper type 1 response in breast tumorigenesis and the potential for immune restorationQ36107949
Cancer immunoediting by the innate immune system in the absence of adaptive immunity.Q36278057
Resistance to Trastuzumab in Breast Cancer.Q36318226
Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expressionQ36388523
Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunityQ36500807
CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT.Q36540532
A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancerQ36547750
Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?Q36613598
Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanesQ36624237
P921main subjectimmunotherapyQ1427096
P304page(s)1544
P577publication date2017-11-13
P1433published inFrontiers in ImmunologyQ27723748
P1476titleInterplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy
P478volume8