| scholarly article | Q13442814 |
| P50 | author | Adriano Aguzzi | Q375410 |
| Mathias Heikenwalder | Q43369827 | ||
| Markus Tolnay | Q47157920 | ||
| Thomas Rülicke | Q57549501 | ||
| Jens Pahnke | Q59540336 | ||
| P2093 | author name string | Markus Tolnay | |
| Hartmut H Niemann | |||
| Frank Baumann | |||
| Ulrich Kloz | |||
| Alexander Bürkle | |||
| Christine Brabeck | |||
| P2860 | cites work | Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection | Q24534939 |
| Perspectives: neurobiology. PrP's double causes trouble | Q28138888 | ||
| Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel | Q28145970 | ||
| Mice devoid of PrP are resistant to scrapie | Q28249108 | ||
| NEUROBIOLOGY:PrP's Double Causes Trouble | Q29544375 | ||
| Novel proteinaceous infectious particles cause scrapie | Q29547678 | ||
| Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation | Q34069408 | ||
| The black cat/white cat principle of signal integration in bacterial promoters | Q34166888 | ||
| Three-dimensional structures of prion proteins | Q34305023 | ||
| A transmembrane form of the prion protein in neurodegenerative disease | Q34454961 | ||
| A cellular gene encodes scrapie PrP 27-30 protein | Q34557641 | ||
| Mammalian prion biology: one century of evolving concepts | Q35639302 | ||
| The role of PrP in health and disease | Q35881598 | ||
| COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform | Q36039920 | ||
| Cellular prion protein transduces neuroprotective signals | Q39644937 | ||
| Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain | Q39714572 | ||
| Prion protein is a component of the multimolecular signaling complex involved in T cell activation. | Q40585109 | ||
| Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies | Q40689387 | ||
| Prion protein protects human neurons against Bax-mediated apoptosis | Q40783610 | ||
| Signal transduction through prion protein | Q40855079 | ||
| Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. | Q41064177 | ||
| Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein | Q43522858 | ||
| Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol | Q44184139 | ||
| Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation | Q44279170 | ||
| Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels | Q44626756 | ||
| Prions prevent neuronal cell-line death. | Q48152328 | ||
| A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination | Q48180328 | ||
| No superoxide dismutase activity of cellular prion protein in vivo | Q48185616 | ||
| Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions | Q48479400 | ||
| Nearly ubiquitous tissue distribution of the scrapie agent precursor protein | Q48595206 | ||
| Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity | Q48670908 | ||
| Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease | Q48691137 | ||
| Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform | Q48767220 | ||
| Normal host prion protein necessary for scrapie-induced neurotoxicity | Q49160879 | ||
| A vector for expressing foreign genes in the brains and hearts of transgenic mice | Q54965153 | ||
| Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC | Q57083651 | ||
| Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo | Q61463936 | ||
| Pronuclear microinjection of mouse zygotes | Q79820188 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | toxicity | Q274160 |
| prion protein family | Q24724413 | ||
| P304 | page(s) | 538-547 | |
| P577 | publication date | 2007-01-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | Lethal recessive myelin toxicity of prion protein lacking its central domain | |
| P478 | volume | 26 |
| Q34397037 | A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes |
| Q41907406 | A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide |
| Q36686430 | A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein. |
| Q33882410 | A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death |
| Q35626193 | A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation. |
| Q37459305 | A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein |
| Q39486840 | A nine amino acid domain is essential for mutant prion protein toxicity |
| Q33748230 | A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. |
| Q24656032 | A systems approach to prion disease |
| Q91771298 | Altered distribution, aggregation, and protease resistance of cellular prion protein following intracranial inoculation |
| Q34800606 | An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity |
| Q37080562 | Antagonistic roles of the N-terminal domain of prion protein to doppel |
| Q46611794 | Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein |
| Q34094490 | Axonal prion protein is required for peripheral myelin maintenance |
| Q33757721 | Beta-amyloid oligomers and cellular prion protein in Alzheimer's disease |
| Q92649273 | Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease |
| Q34391341 | Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity |
| Q22251089 | Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers |
| Q33768032 | Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease |
| Q36432753 | Cellular prion protein: from physiology to pathology |
| Q57372680 | Characterization of the Properties and Trafficking of an Anchorless Form of the Prion Protein |
| Q34922583 | Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion |
| Q39604213 | Conserved stress-protective activity between prion protein and Shadoo |
| Q33595425 | Context dependent neuroprotective properties of prion protein (PrP). |
| Q30485527 | De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis |
| Q37627076 | De novo mammalian prion synthesis |
| Q38279734 | Decoding the function of the N-terminal tail of the cellular prion protein to inspire novel therapeutic avenues for neurodegenerative diseases |
| Q36481861 | Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survival |
| Q33967960 | Dissociation of infectivity from seeding ability in prions with alternate docking mechanism |
| Q40650405 | Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells |
| Q40451562 | Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice |
| Q33675107 | Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells |
| Q35915982 | Doppel induces degeneration of cerebellar Purkinje cells independently of Bax |
| Q48379992 | Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion |
| Q39245173 | Dual role of cellular prion protein in normal host and Alzheimer's disease |
| Q28910222 | Early onset prion disease from octarepeat expansion correlates with copper binding properties |
| Q30352829 | Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning. |
| Q37335792 | Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. |
| Q33912630 | Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view |
| Q56763705 | Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP) into Pathogenic Prion Protein (PrP) |
| Q36744507 | Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein |
| Q33425420 | Fishing for prion protein function |
| Q34263032 | Five questions on prion diseases |
| Q33501189 | Functionally relevant domains of the prion protein identified in vivo |
| Q37093469 | Generating Bona Fide Mammalian Prions with Internal Deletions |
| Q38734225 | Identification of Anti-prion Compounds using a Novel Cellular Assay. |
| Q33296885 | In vitro and in vivo neurotoxicity of prion protein oligomers. |
| Q47099606 | Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. |
| Q40071080 | Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases |
| Q36856446 | Insights into prion strains and neurotoxicity |
| Q36003628 | Integrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication |
| Q27308826 | Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains |
| Q35918928 | Ion channels induced by the prion protein: mediators of neurotoxicity. |
| Q37627093 | Is, indeed, the prion protein a Harlequin servant of "many" masters? |
| Q33834732 | Loss of prion protein induces a primed state of type I interferon-responsive genes. |
| Q39250023 | Lysosomal Quality Control in Prion Diseases |
| Q30424667 | Mammalian prions: tolerance to sequence changes-how far? |
| Q38800950 | Mechanisms of prion-induced neurodegeneration. |
| Q46963608 | Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice. |
| Q30032301 | Memory impairment in transgenic Alzheimer mice requires cellular prion protein |
| Q36481434 | Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice |
| Q38154145 | Myelin damage due to local quantitative abnormalities in normal prion levels: evidence from subacute combined degeneration and multiple sclerosis |
| Q27316068 | Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP |
| Q34074520 | Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells |
| Q36974937 | Neurotoxic species in prion disease: a role for PrP isoforms? |
| Q28535083 | Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein |
| Q44706961 | Perturbation of T-cell development by insertional mutation of a PrP transgene. |
| Q34307236 | PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease? |
| Q38099068 | Prion disease: a tale of folds and strains |
| Q36767231 | Prion neurotoxicity: insights from prion protein mutants |
| Q37995916 | Prion potency in stem cells biology |
| Q38027947 | Prion processing: a double-edged sword? |
| Q38340595 | Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP. |
| Q38200475 | Prion protein and cancers |
| Q35740063 | Prion protein at the crossroads of physiology and disease. |
| Q35094535 | Prion protein biosynthesis and its emerging role in neurodegeneration |
| Q47271332 | Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. |
| Q42745830 | Prion protein lacks robust cytoprotective activity in cultured cells |
| Q37290904 | Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein |
| Q41970102 | Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice |
| Q38064769 | Prions, prionoids and pathogenic proteins in Alzheimer disease |
| Q34098028 | Protease-resistant prions selectively decrease Shadoo protein |
| Q35311053 | Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein |
| Q34101110 | Protein aggregation diseases: pathogenicity and therapeutic perspectives |
| Q46349859 | Proteolysis of prion protein by cathepsin S generates a soluble beta-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms |
| Q37745468 | Regulation of RhoA activity by the cellular prion protein |
| Q36796856 | Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation |
| Q34474868 | Review: contribution of transgenic models to understanding human prion disease. |
| Q89762189 | RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity |
| Q37580683 | Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors? |
| Q38081918 | Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration. |
| Q39970242 | Stress-protective signalling of prion protein is corrupted by scrapie prions |
| Q92209952 | Structural Consequences of Copper Binding to the Prion Protein |
| Q52602016 | Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein. |
| Q91800637 | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion |
| Q37035847 | Structural transitions in full-length human prion protein detected by xenon as probe and spin labeling of the N-terminal domain |
| Q40093030 | The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections |
| Q26782895 | The Cellular Prion Protein: A Player in Immunological Quiescence |
| Q34043470 | The N-terminal, polybasic region is critical for prion protein neuroprotective activity |
| Q33793628 | The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. |
| Q90227644 | The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer's Disease (AD) |
| Q33623592 | The biological function of the cellular prion protein: an update |
| Q33408170 | The comprehensive native interactome of a fully functional tagged prion protein |
| Q35624321 | The elusive role of the prion protein and the mechanism of toxicity in prion disease. |
| Q39680946 | The hydrophobic core region governs mutant prion protein aggregation and intracellular retention |
| Q38826643 | The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion. |
| Q34412881 | The prion hypothesis: from biological anomaly to basic regulatory mechanism |
| Q37397364 | The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells. |
| Q37080450 | The prion protein knockout mouse: a phenotype under challenge |
| Q35137829 | The sheddase ADAM10 is a potent modulator of prion disease. |
| Q34200990 | The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells |
| Q27685314 | The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein |
| Q37064056 | The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases |
| Q33531737 | Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations |
| Q39139955 | Unique structural properties associated with mouse prion Δ105-125 protein |
| Q36604907 | Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface |
| Q27302091 | ZyFISH: a simple, rapid and reliable zygosity assay for transgenic mice |
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