Functionally relevant domains of the prion protein identified in vivo

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Functionally relevant domains of the prion protein identified in vivo is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.6707B
P356DOI10.1371/JOURNAL.PONE.0006707
P932PMC publication ID2733036
P698PubMed publication ID19738901
P5875ResearchGate publication ID26797722

P50authorAdriano AguzziQ375410
Jens PahnkeQ59540336
Markus TolnayQ47157920
P2093author name stringIvan Radovanovic
Markus Tolnay
Thomas Rülicke
Juliane Bremer
Frank Baumann
P2860cites workStress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotectionQ24534939
Doppel-induced cerebellar degeneration in transgenic miceQ24555049
NMR solution structure of the human prion proteinQ27620845
NMR structure of the human doppel proteinQ27640537
Perspectives: neurobiology. PrP's double causes troubleQ28138888
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppelQ28145970
Mice devoid of PrP are resistant to scrapieQ28249108
Anchorless prion protein results in infectious amyloid disease without clinical scrapieQ28254406
NEUROBIOLOGY:PrP's Double Causes TroubleQ29544375
Novel proteinaceous infectious particles cause scrapieQ29547678
Lethal recessive myelin toxicity of prion protein lacking its central domainQ30478899
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathwayQ30484021
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopesQ33390385
Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assayQ33455591
Absence of the prion protein homologue Doppel causes male sterilityQ34079215
NMR structure of the bovine prion protein isolated from healthy calf brainsQ34166383
Three-dimensional structures of prion proteinsQ34305023
Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPCQ57083651
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in VivoQ61463936
Pronuclear microinjection of mouse zygotesQ79820188
Prion protein attenuates excitotoxicity by inhibiting NMDA receptorsQ81339233
Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expressionQ34512335
Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.Q34536351
A cellular gene encodes scrapie PrP 27-30 proteinQ34557641
Cellular prion protein and caveolin-1 interaction in a neuronal cell line precedes Fyn/Erk 1/2 signal transduction.Q35016910
Three-dimensional structures of the prion protein and its doppelQ35122356
Games played by rogue proteins in prion disorders and Alzheimer's diseaseQ35573421
Mammalian prion biology: one century of evolving conceptsQ35639302
Prion-induced amyloid heart disease with high blood infectivity in transgenic miceQ35676392
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.Q36321586
The functional links between prion protein and copperQ36455641
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brainQ39714572
Canine MDCK cell lines are refractory to infection with human and mouse prionsQ39990591
Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in miceQ40451562
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' regionQ40508891
Prion protein is a component of the multimolecular signaling complex involved in T cell activation.Q40585109
Signal transduction through prion proteinQ40855079
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.Q41064177
The role of the octarepeat region in neuroprotective function of the cellular prion proteinQ42080796
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.Q42976640
Normal development and behaviour of mice lacking the neuronal cell-surface PrP proteinQ43522858
Identification of the heparan sulfate binding sites in the cellular prion proteinQ43908316
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradationQ44381518
Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survivalQ44391055
Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced NeurodegenerationQ44448848
A human prion protein peptide (PrP59–91) protects against copper neurotoxicityQ44600127
Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion proteinQ47351716
Axonal swellings and degeneration in mice lacking the major proteolipid of myelinQ48004959
A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelinationQ48180328
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesionsQ48479400
Nearly ubiquitous tissue distribution of the scrapie agent precursor proteinQ48595206
Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoformQ48767220
Cell biology. Prion toxicity: all sail and no anchorQ48872569
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP geneQ49010616
Normal host prion protein necessary for scrapie-induced neurotoxicityQ49160879
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectprion protein familyQ24724413
P304page(s)e6707
P577publication date2009-09-07
P1433published inPLOS OneQ564954
P1476titleFunctionally relevant domains of the prion protein identified in vivo
P478volume4

Reverse relations

cites work (P2860)
Q34800606An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity
Q46611794Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein
Q34538462Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI.
Q36432753Cellular prion protein: from physiology to pathology
Q34922583Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion
Q36481861Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survival
Q40650405Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells
Q37093469Generating Bona Fide Mammalian Prions with Internal Deletions
Q27308826Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains
Q46963608Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.
Q38154145Myelin damage due to local quantitative abnormalities in normal prion levels: evidence from subacute combined degeneration and multiple sclerosis
Q34074520Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells
Q47271332Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
Q27312168The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
Q42151993The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo
Q33531737Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations
Q39638073Unraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity
Q27302091ZyFISH: a simple, rapid and reliable zygosity assay for transgenic mice

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