| scholarly article | Q13442814 |
| P50 | author | Roberto Chiesa | Q55245142 |
| Heather M Lamb | Q90840890 | ||
| David A Harris | Q39486896 | ||
| Kevin A. Roth | Q42407889 | ||
| P2093 | author name string | Aimin Li | |
| Leanne R Stewart | |||
| Heather M Christensen | |||
| P2860 | cites work | Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection | Q24534939 |
| Doppel-induced cerebellar degeneration in transgenic mice | Q24555049 | ||
| Prions | Q24633319 | ||
| NMR solution structure of the human prion protein | Q27620845 | ||
| Two different neurodegenerative diseases caused by proteins with similar structures | Q27630179 | ||
| NMR structure of the human doppel protein | Q27640537 | ||
| Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel | Q28145970 | ||
| Anchorless prion protein results in infectious amyloid disease without clinical scrapie | Q28254406 | ||
| Human Doppel and prion protein share common membrane microdomains and internalization pathways | Q28267413 | ||
| Mammalian prion protein suppresses Bax-induced cell death in yeast | Q28594938 | ||
| Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC | Q57083651 | ||
| Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo | Q61463936 | ||
| Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment | Q72568587 | ||
| Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene | Q74126314 | ||
| Prions prevent brain damage after experimental brain injury: a preliminary report | Q75372604 | ||
| Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons | Q81623498 | ||
| NMR structure of the bovine prion protein isolated from healthy calf brains | Q34166383 | ||
| Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. | Q34273746 | ||
| A transmembrane form of the prion protein in neurodegenerative disease | Q34454961 | ||
| Prion protein accumulation and neuroprotection in hypoxic brain damage | Q35102832 | ||
| Trafficking, turnover and membrane topology of PrP. | Q35548978 | ||
| A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum. | Q35582041 | ||
| Mammalian prion biology: one century of evolving concepts | Q35639302 | ||
| Cellular prion protein neuroprotective function: implications in prion diseases | Q36006619 | ||
| Prion protein expression in different species: analysis with a panel of new mAbs | Q36222036 | ||
| New insights into prion structure and toxicity. | Q36468607 | ||
| Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein | Q36741703 | ||
| Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment | Q37074594 | ||
| A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells | Q38290309 | ||
| Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain | Q39714572 | ||
| Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia | Q39777445 | ||
| Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells | Q40431685 | ||
| Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis. | Q40450632 | ||
| A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. | Q40477785 | ||
| Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region | Q40508891 | ||
| Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death | Q40595404 | ||
| Prion protein protects human neurons against Bax-mediated apoptosis | Q40783610 | ||
| Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. | Q41064177 | ||
| Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein | Q43522858 | ||
| Lack of prion protein expression results in a neuronal phenotype sensitive to stress | Q43849051 | ||
| Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. | Q45983248 | ||
| A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform | Q46042531 | ||
| Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1. | Q46489954 | ||
| Role of caspase-3 in ethanol-induced developmental neurodegeneration | Q46520175 | ||
| 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal | Q47562788 | ||
| Prions prevent neuronal cell-line death. | Q48152328 | ||
| A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination | Q48180328 | ||
| Neurotoxicity of a prion protein fragment | Q48304223 | ||
| Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. | Q48308927 | ||
| Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites. | Q48333630 | ||
| Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions | Q48479400 | ||
| Truncated forms of the human prion protein in normal brain and in prion diseases | Q48807964 | ||
| Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells | Q48857384 | ||
| Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene | Q49010616 | ||
| Normal host prion protein necessary for scrapie-induced neurotoxicity | Q49160879 | ||
| The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species. | Q51820978 | ||
| A vector for expressing foreign genes in the brains and hearts of transgenic mice | Q54965153 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | prion protein family | Q24724413 |
| P304 | page(s) | 548-558 | |
| P577 | publication date | 2007-01-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125 | |
| P478 | volume | 26 |
| Q34397037 | A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes |
| Q41907406 | A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide |
| Q36686430 | A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein. |
| Q33882410 | A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death |
| Q37013751 | A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity |
| Q35626193 | A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation. |
| Q37459305 | A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein |
| Q39486840 | A nine amino acid domain is essential for mutant prion protein toxicity |
| Q33748230 | A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. |
| Q27301257 | Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. |
| Q37107407 | Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities. |
| Q91771298 | Altered distribution, aggregation, and protease resistance of cellular prion protein following intracranial inoculation |
| Q34800606 | An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity |
| Q47727920 | An inter-domain regulatory mechanism controls toxic activities of PrPC. |
| Q37080562 | Antagonistic roles of the N-terminal domain of prion protein to doppel |
| Q46611794 | Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein |
| Q33757721 | Beta-amyloid oligomers and cellular prion protein in Alzheimer's disease |
| Q36912518 | Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse |
| Q92649273 | Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease |
| Q22251089 | Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers |
| Q36432753 | Cellular prion protein: from physiology to pathology |
| Q41910140 | Common themes in PrP signaling: the Src remains the same |
| Q34922583 | Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion |
| Q39604213 | Conserved stress-protective activity between prion protein and Shadoo |
| Q33595425 | Context dependent neuroprotective properties of prion protein (PrP). |
| Q33999707 | Copper binding extrinsic to the octarepeat region in the prion protein |
| Q30485527 | De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis |
| Q37627076 | De novo mammalian prion synthesis |
| Q38279734 | Decoding the function of the N-terminal tail of the cellular prion protein to inspire novel therapeutic avenues for neurodegenerative diseases |
| Q36481861 | Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survival |
| Q33967960 | Dissociation of infectivity from seeding ability in prions with alternate docking mechanism |
| Q40650405 | Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells |
| Q40451562 | Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice |
| Q33675107 | Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells |
| Q35915982 | Doppel induces degeneration of cerebellar Purkinje cells independently of Bax |
| Q28910222 | Early onset prion disease from octarepeat expansion correlates with copper binding properties |
| Q30352829 | Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning. |
| Q37335792 | Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. |
| Q36744507 | Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein |
| Q33425420 | Fishing for prion protein function |
| Q34263032 | Five questions on prion diseases |
| Q33501189 | Functionally relevant domains of the prion protein identified in vivo |
| Q28597985 | Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory |
| Q37093469 | Generating Bona Fide Mammalian Prions with Internal Deletions |
| Q38734225 | Identification of Anti-prion Compounds using a Novel Cellular Assay. |
| Q33296885 | In vitro and in vivo neurotoxicity of prion protein oligomers. |
| Q93028769 | In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain |
| Q40071080 | Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases |
| Q36003628 | Integrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication |
| Q35918928 | Ion channels induced by the prion protein: mediators of neurotoxicity. |
| Q37627093 | Is, indeed, the prion protein a Harlequin servant of "many" masters? |
| Q28509844 | Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency |
| Q39250023 | Lysosomal Quality Control in Prion Diseases |
| Q30424667 | Mammalian prions: tolerance to sequence changes-how far? |
| Q38800950 | Mechanisms of prion-induced neurodegeneration. |
| Q30032301 | Memory impairment in transgenic Alzheimer mice requires cellular prion protein |
| Q92150816 | Mutations in Prion Protein Gene: Pathogenic Mechanisms in C-Terminal vs. N-Terminal Domain, a Review |
| Q38154145 | Myelin damage due to local quantitative abnormalities in normal prion levels: evidence from subacute combined degeneration and multiple sclerosis |
| Q48298632 | N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways. |
| Q27316068 | Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP |
| Q34074520 | Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells |
| Q36974937 | Neurotoxic species in prion disease: a role for PrP isoforms? |
| Q46734839 | Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies. |
| Q44706961 | Perturbation of T-cell development by insertional mutation of a PrP transgene. |
| Q34307236 | PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease? |
| Q38099068 | Prion disease: a tale of folds and strains |
| Q36767231 | Prion neurotoxicity: insights from prion protein mutants |
| Q37995916 | Prion potency in stem cells biology |
| Q38027947 | Prion processing: a double-edged sword? |
| Q35740063 | Prion protein at the crossroads of physiology and disease. |
| Q35094535 | Prion protein biosynthesis and its emerging role in neurodegeneration |
| Q34570047 | Prion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology |
| Q47271332 | Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. |
| Q42745830 | Prion protein lacks robust cytoprotective activity in cultured cells |
| Q35009728 | Prion protein misfolding |
| Q41970102 | Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice |
| Q38130627 | Probing early misfolding events in prion protein mutants by NMR spectroscopy. |
| Q34098028 | Protease-resistant prions selectively decrease Shadoo protein |
| Q35311053 | Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein |
| Q34101110 | Protein aggregation diseases: pathogenicity and therapeutic perspectives |
| Q46349859 | Proteolysis of prion protein by cathepsin S generates a soluble beta-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms |
| Q36796856 | Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation |
| Q34474868 | Review: contribution of transgenic models to understanding human prion disease. |
| Q37580683 | Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors? |
| Q27006904 | Shadoo/PrP (Sprn(0/0) /Prnp(0/0) ) double knockout mice: more than zeroes |
| Q39970242 | Stress-protective signalling of prion protein is corrupted by scrapie prions |
| Q92209952 | Structural Consequences of Copper Binding to the Prion Protein |
| Q61456169 | Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions |
| Q91800637 | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion |
| Q37746968 | Structural factors underlying the species barrier and susceptibility to infection in prion disease. |
| Q37035847 | Structural transitions in full-length human prion protein detected by xenon as probe and spin labeling of the N-terminal domain |
| Q40093030 | The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections |
| Q34043470 | The N-terminal, polybasic region is critical for prion protein neuroprotective activity |
| Q36208488 | The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc). |
| Q33793628 | The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. |
| Q36421728 | The cellular form of the prion protein is involved in controlling cell cycle dynamics, self-renewal, and the fate of human embryonic stem cell differentiation. |
| Q36003019 | The cellular prion protein (PrP(C)): its physiological function and role in disease |
| Q35624321 | The elusive role of the prion protein and the mechanism of toxicity in prion disease. |
| Q41990729 | The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β. |
| Q38826643 | The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion. |
| Q37397364 | The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells. |
| Q34200990 | The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells |
| Q37064056 | The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases |
| Q39804076 | Transient expressions of doppel and its structural analog prionDelta32-121 in SH-SY5Y cells caused cytotoxicity possibly by triggering similar apoptosis pathway |
| Q33531737 | Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations |
| Q39139955 | Unique structural properties associated with mouse prion Δ105-125 protein |
| Q36604907 | Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface |
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