Unraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity

scientific article published on July 2012

Unraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/PRI.19639
P932PMC publication ID3399533
P698PubMed publication ID22437735
P5875ResearchGate publication ID221904287

P50authorJosé Antonio Del RíoQ38319564
P2093author name stringFranc Llorens
P2860cites workMetabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.Q51035911
Developmental expression of the prion protein gene in glial cellsQ52209886
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.Q53314398
Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.Q53664270
Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPCQ57083651
Altered circadian activity rhythms and sleep in mice devoid of prion proteinQ59071240
Generalized convulsive status epilepticus in Creutzfeldt–Jakob diseaseQ59416825
Increased Sensitivity to Seizures in Mice Lacking Cellular Prion ProteinQ59683939
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in VivoQ61463936
Periodic lateralized epileptiform complexes (PLEDs) in Creutzfeldt-Jakob diseaseQ72137438
Epilepsia partialis continua in Creutzfeldt-Jakob diseaseQ73317185
Is loss of function of the prion protein the cause of prion disorders?Q73580418
Expression of Prnp mRNA (prion protein gene) in mouse spermatogenic cellsQ80930975
Threshold for epileptiform activity is elevated in prion knockout miceQ83322867
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersQ22251089
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotectionQ24534939
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewalQ24541459
PrionsQ24633319
Insoluble cellular prion protein and its association with prion and Alzheimer diseasesQ27012706
Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant miceQ27337373
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferationQ28138890
Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neuronsQ28245704
Physiology of the prion proteinQ28275220
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperonesQ28476253
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 geneQ28507982
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient miceQ28586796
PrPC directly interacts with proteins involved in signaling pathwaysQ28592791
Memory impairment in transgenic Alzheimer mice requires cellular prion proteinQ30032301
Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampusQ30160089
Prion protein attenuates excitotoxicity by inhibiting NMDA receptorsQ30481829
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion proteinQ32035009
Molecular cloning of a candidate chicken prion proteinQ33191659
Gene expression alterations in brains of mice infected with three strains of scrapieQ33243428
In vitro and in vivo neurotoxicity of prion protein oligomers.Q33296885
Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genesQ33322227
The comprehensive native interactome of a fully functional tagged prion proteinQ33408170
Functionally relevant domains of the prion protein identified in vivoQ33501189
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoringQ33539797
Context dependent neuroprotective properties of prion protein (PrP).Q33595425
Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathyQ33769602
Proteomics approach to identify the interacting partners of cellular prion protein and characterization of Rab7a interaction in neuronal cellsQ33908948
Copper binding extrinsic to the octarepeat region in the prion proteinQ33999707
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTORQ34059200
Axonal prion protein is required for peripheral myelin maintenanceQ34094490
Prion protein and Abeta-related synaptic toxicity impairmentQ34233877
Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.Q34299079
Hippocampal synaptic plasticity in mice devoid of cellular prion proteinQ34365739
Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout miceQ34699394
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brainQ34868772
Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators.Q35006483
Cellular prion protein: implications in seizures and epilepsyQ35018699
Prion protein accumulation and neuroprotection in hypoxic brain damageQ35102832
Cellular prion protein function in copper homeostasis and redox signalling at the synapseQ35177466
The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.Q35184662
Unaltered prion protein expression in Alzheimer disease patientsQ35194930
Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms.Q35205306
Towards cellular receptors for prionsQ35588133
Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapyQ36050610
Prions and exosomes: from PrPc trafficking to PrPsc propagationQ36229154
Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitroQ36282990
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.Q36321586
The prion protein and lipid raftsQ36447789
Cellular prion protein signaling in serotonergic neuronal cellsQ36779221
Cellular prion protein electron microscopy: attempts/limits and clues to a synaptic trait. Implications in neurodegeneration processQ37072501
The prion protein knockout mouse: a phenotype under challengeQ37080450
NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.Q37088888
New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein.Q37518038
Prion protein: orchestrating neurotrophic activities.Q37600568
Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampusQ37693769
Sporadic Creutzfeldt-Jakob disease presenting as nonconvulsive status epilepticus case report and review of the literatureQ37739628
JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative AbnormalitiesQ37793978
The role of lipid rafts in prion protein biologyQ37825134
Genetics of prion diseaseQ37870102
Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 bindingQ38274565
Cellular prion protein transduces neuroprotective signalsQ39644937
CREB-dependent gene regulation by prion protein: impact on MMP-9 and beta-dystroglycan.Q39948509
Dose-dependent, prion protein (PrP)-mediated facilitation of excitatory synaptic transmission in the mouse hippocampusQ40797634
Signal transduction through prion proteinQ40855079
Scrapie and cellular PrP isoforms are encoded by the same chromosomal geneQ41982232
Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob diseaseQ42050382
All quiet on the neuronal front: NMDA receptor inhibition by prion proteinQ42091975
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizureQ43289017
Mild cognitive deficits associated to neocortical microgyria in mice with genetic deletion of cellular prion protein.Q43516326
Normal development and behaviour of mice lacking the neuronal cell-surface PrP proteinQ43522858
Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampusQ43798516
Lack of prion protein expression results in a neuronal phenotype sensitive to stressQ43849051
Depressive-like behaviour of mice lacking cellular prion proteinQ44190777
Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survivalQ44391055
Specific pathophysiological functions of JNK isoforms in the brainQ45240068
Amyloid-beta oligomers increase the localization of prion protein at the cell surfaceQ45827724
Asynchronous kidney allograft loss after simultaneous pancreas-kidney transplantation: impact on pancreas allograft outcome at a single center.Q45958472
Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient miceQ46214671
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusionQ46727662
Prion protein potentiates acetylcholine release at the neuromuscular junctionQ46779822
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normalQ47562788
Prion protein (PrPc) immunocytochemistry and expression of the green fluorescent protein reporter gene under control of the bovine PrP gene promoter in the mouse brainQ47723535
Microglial expression of the prion proteinQ47959261
Prion protein is necessary for normal synaptic functionQ48087355
Prions prevent neuronal cell-line death.Q48152328
Expression of proteins linked to exocytosis and neurotransmission in patients with Creutzfeldt-Jakob diseaseQ48200986
Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptorsQ48270909
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null miceQ48305162
Tissue-specific expression pattern of bovine prion gene: quantification using real-time RT-PCR.Q48368484
Role of cellular prion protein on LTP expression in aged mice.Q48520160
Selective expression of prion protein in peripheral tissues of the adult mouseQ48544898
Characterization of prion protein-enriched domains, isolated from rat cerebellar granule cells in cultureQ48588068
Abnormal synaptic protein expression and cell death in murine scrapie.Q48605040
Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies.Q48933812
Unaltered SNARE complex formation in an in vivo model of prion diseaseQ48965098
P433issue3
P921main subjectexcitotoxicityQ901117
P304page(s)245-251
P577publication date2012-07-01
P1433published inPrionQ26842757
P1476titleUnraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity
P478volume6

Reverse relations

cites work (P2860)
Q24317448Anchorless 23-230 PrPC interactomics for elucidation of PrPC protective role
Q33565752Expression of Reactive Oxygen Species-Related Transcripts in Egyptian Children With Autism
Q28597985Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory
Q38129313Gene expression resulting from PrPC ablation and PrPC overexpression in murine and cellular models
Q39431937Implications of peptide assemblies in amyloid diseases
Q27308826Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains
Q36912263Lack of influence of prion protein gene expression on kainate-induced seizures in mice: studies using congenic, coisogenic and transgenic strains.
Q28071519NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?
Q39157220PrP(C) regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells.
Q43230803RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome
Q90047524The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain

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