scholarly article | Q13442814 |
P356 | DOI | 10.1074/JBC.M303655200 |
P698 | PubMed publication ID | 12759361 |
P50 | author | Ryuichiro Atarashi | Q88499298 |
P2093 | author name string | Noriyuki Nishida | |
Shigeru Katamine | |||
Suehiro Sakaguchi | |||
Kazuto Shigematsu | |||
Shinji Goto | |||
Takahito Kondo | |||
P2860 | cites work | Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein | Q43522858 |
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. | Q45962479 | ||
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. | Q45970590 | ||
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal | Q47562788 | ||
Prions prevent neuronal cell-line death. | Q48152328 | ||
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions | Q48479400 | ||
Truncated forms of the human prion protein in normal brain and in prion diseases | Q48807964 | ||
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice | Q48963662 | ||
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene | Q49010616 | ||
Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein. | Q55065425 | ||
Brain copper content and cuproenzyme activity do not vary with prion protein expression level | Q73538276 | ||
Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene | Q74126314 | ||
Prion Protein Biology | Q21972822 | ||
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection | Q24534939 | ||
Doppel-induced cerebellar degeneration in transgenic mice | Q24555049 | ||
Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases | Q27626645 | ||
Two different neurodegenerative diseases caused by proteins with similar structures | Q27630179 | ||
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel | Q28145970 | ||
Mice devoid of PrP are resistant to scrapie | Q28249108 | ||
Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein | Q28367705 | ||
The PrP-like protein Doppel binds copper | Q28506863 | ||
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury | Q28511628 | ||
Copper stimulates endocytosis of the prion protein | Q28589040 | ||
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss | Q30876363 | ||
In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies | Q31816626 | ||
Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein | Q33794942 | ||
Absence of the prion protein homologue Doppel causes male sterility | Q34079215 | ||
Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl. | Q34536351 | ||
Peptide aggregation in neurodegenerative disease | Q34738985 | ||
Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells | Q36225344 | ||
Location and properties of metal-binding sites on the human prion protein. | Q37104327 | ||
A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH. | Q37376722 | ||
Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease | Q39080950 | ||
Cellular prion protein transduces neuroprotective signals | Q39644937 | ||
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain | Q39714572 | ||
Prion protein protects human neurons against Bax-mediated apoptosis | Q40783610 | ||
Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons | Q40859808 | ||
Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice | Q41618801 | ||
Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration | Q42048578 | ||
Prion protein expression and superoxide dismutase activity | Q42991570 | ||
P433 | issue | 31 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | neurodegeneration | Q1755122 |
prion protein family | Q24724413 | ||
P304 | page(s) | 28944-28949 | |
P577 | publication date | 2003-05-19 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration | |
P478 | volume | 278 |
Q39486840 | A nine amino acid domain is essential for mutant prion protein toxicity |
Q34673565 | Age-dependent impairment of eyeblink conditioning in prion protein-deficient mice. |
Q37080562 | Antagonistic roles of the N-terminal domain of prion protein to doppel |
Q36006619 | Cellular prion protein neuroprotective function: implications in prion diseases |
Q36432753 | Cellular prion protein: from physiology to pathology |
Q40451562 | Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice |
Q33501189 | Functionally relevant domains of the prion protein identified in vivo |
Q40508891 | Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region |
Q37262632 | Helix 3 is necessary and sufficient for prion protein's anti-Bax function |
Q34058767 | Instability of the octarepeat region of the human prion protein gene |
Q35098319 | Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice |
Q34351433 | Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice |
Q28475611 | Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration |
Q41970102 | Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice |
Q35023923 | Prion strain-dependent differences in conversion of mutant prion proteins in cell culture |
Q26782895 | The Cellular Prion Protein: A Player in Immunological Quiescence |
Q34043470 | The N-terminal, polybasic region is critical for prion protein neuroprotective activity |
Q42151993 | The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo |
Q36003019 | The cellular prion protein (PrP(C)): its physiological function and role in disease |
Q41870342 | The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells. |
Q37080450 | The prion protein knockout mouse: a phenotype under challenge |
Q42008958 | The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. |
Q37074594 | Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment |
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