CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

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CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI.1853
P932PMC publication ID2923071
P698PubMed publication ID20228797
P5875ResearchGate publication ID41944316

P50authorVincenzo CerundoloQ40619109
Patricia BarralQ59563448
Nico van RooijenQ62569422
Facundo D BatistaQ88612216
P2093author name stringAndreas Bruckbauer
Paolo Polzella
P2860cites workAntigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cellsQ24796689
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoidsQ24806047
Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodesQ28202515
CD1: antigen presentation and T cell functionQ28251508
The biology of NKT cellsQ28277482
Siglecs and their roles in the immune systemQ28294469
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humansQ28511526
Two-photon imaging of lymphocyte motility and antigen response in intact lymph nodeQ29615099
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.Q30355212
Invariant NKT cells sustain specific B cell responses and memoryQ30479030
Dynamics of neutrophil migration in lymph nodes during infectionQ30484144
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organsQ30489790
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.Q30491651
Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph nodeQ30541235
Glycolipid antigen processing for presentation by CD1d molecules.Q31832878
Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoidsQ33318195
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashionQ33762686
Patterns of lymphatic drainage in the adult laboratory ratQ34106051
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatographyQ34722878
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cellsQ34764301
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.Q36008100
Toward an understanding of NKT cell biology: progress and paradoxesQ36072480
Working with NKT cells--pitfalls and practicalitiesQ36166764
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activationQ36300047
Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered proteinQ36371349
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.Q36383089
NK T cells provide lipid antigen-specific cognate help for B cellsQ36751506
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivoQ36751511
The unique role of natural killer T cells in the response to microorganismsQ36814724
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signalsQ37003800
Structural and functional aspects of lipid binding by CD1 moleculesQ37204314
Harnessing invariant NKT cells in vaccination strategiesQ37349692
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteriaQ38466705
Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramideQ39841856
Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells.Q39843059
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cellsQ39960222
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cellsQ40068378
NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cellsQ40618321
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applicationsQ40701479
Recognition of bacterial glycosphingolipids by natural killer T cellsQ44582192
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodesQ44639419
Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions.Q45935220
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.Q46017170
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.Q47423311
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infectionsQ50092191
Phenotypic and functional differences between NKT cells colonizing splanchnic and peripheral lymph nodes.Q52938071
Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged GlycosphingolipidsQ57831266
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunityQ73691187
Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cellsQ79734101
B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph nodeQ80688189
Cell surface recycling of internalized antigen permits dendritic cell priming of B cellsQ81476297
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
lymph nodeQ170758
P304page(s)303-312
P577publication date2010-03-14
P1433published inNature ImmunologyQ1071725
P1476titleCD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
P478volume11

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