Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

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Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses is …
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scholarly articleQ13442814

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P356DOI10.1038/NI.2166
P698PubMed publication ID22120117

P50authorAxel KalliesQ21077800
Vincenzo CerundoloQ40619109
Stephen L. NuttQ42651674
Dale I GodfreyQ56957983
Patricia BarralQ59563448
Stuart TangyeQ71045268
Cindy S MaQ37830704
P2093author name stringFacundo D Batista
Robert Bittman
Carola G Vinuesa
Robert Brink
Alvin Pratama
Jennifer J Hogan
Jessica Fitch
Pheh-Ping Chang
P2860cites workmTOR regulates memory CD8 T-cell differentiationQ24648624
Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT CellsQ27658388
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivityQ41770910
Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centersQ42944615
CD1d-restricted help to B cells by human invariant natural killer T lymphocytesQ42944844
NKT-cell help to B lymphocytes can occur independently of cognate interaction.Q45880618
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.Q46006953
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursorsQ46553571
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cellsQ47765721
Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infectionQ50072223
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotypeQ53085484
Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T CellsQ62230390
A critical role of costimulation during intrathymic development of invariant NK T cellsQ80633595
A thymic precursor to the NK T cell lineageQ95783850
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
GATA-3 regulates the development and function of invariant NKT cellsQ28590905
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytesQ28591671
Follicular helper CD4 T cells (TFH)Q29615063
Germinal centersQ29616234
Invariant NKT cells sustain specific B cell responses and memoryQ30479030
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodesQ30496134
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responsesQ33656146
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.Q33695371
NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challengeQ34333607
Germinal center B cell and T follicular helper cell development initiates in the interfollicular zoneQ35758747
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cellsQ35848548
Going both ways: immune regulation via CD1d-dependent NKT cellsQ35951531
The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansionQ35978664
Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.Q36229379
Follicular B helper T cells in antibody responses and autoimmunity.Q36302329
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageQ36370202
Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer stainingQ36370359
B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.Q36370721
Germinal centers without T cellsQ36375933
Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene productQ36402758
NK T cells provide lipid antigen-specific cognate help for B cellsQ36751506
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivoQ36751511
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.Q36799306
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell populationQ36837547
Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.Q37018987
SAP-controlled T-B cell interactions underlie germinal centre formationQ37119530
Harnessing invariant NKT cells in vaccination strategiesQ37349692
Follicular helper T cells as cognate regulators of B cell immunityQ37510254
Raising the NKT cell familyQ37688877
The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant siteQ38179197
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)35-43
P577publication date2011-11-27
P1433published inNature ImmunologyQ1071725
P1476titleIdentification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
P478volume13

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