Tumor-Derived Apoptotic Vesicles: With Death They Do Part.

scientific article published on 7 May 2018

Tumor-Derived Apoptotic Vesicles: With Death They Do Part. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3389/FIMMU.2018.00957
P932PMC publication ID5952256
P698PubMed publication ID29780392

P50authorMorad Remy Muhsin-SharafaldineQ118959582
P2093author name stringAlexander D McLellan
P2860cites workCaspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.Q44930829
Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL.Q45073094
Effect of tamoxifen on measurements of hemostasis in healthy womenQ45878122
Mechanistic insight into the procoagulant activity of tumor-derived apoptotic vesicles.Q51317118
Antiapoptotic effect of coagulation factor VIIa.Q51837430
Mitotic catastrophe: a mechanism for avoiding genomic instability.Q52610466
Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.Q52614705
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.Q52935183
The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles.Q53250751
Circulating procoagulant microparticles in cancer patients.Q53292843
Caspases find a new place to hide.Q53338897
Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury.Q54021698
CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.Q55053710
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells.Q55466614
Exfoliation of membrane ecto-enzymes in the form of micro-vesiclesQ55490241
Prognosis of Cancers Associated with Venous ThromboembolismQ57301047
A modified Khorana risk assessment score for venous thromboembolism in cancer patients receiving chemotherapy: the Protecht scoreQ57758028
Apoptosis: caspases orchestrate the ROCK `n' blebQ57910004
Tissue factor, thrombin, and cancerQ35217277
Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane MicrodomainQ35564822
CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cellsQ35567056
Improved characterization of EV preparations based on protein to lipid ratio and lipid propertiesQ35583785
Histopathological patterns of melanoma metastases in sentinel lymph nodesQ35587301
T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infectionQ35753066
Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cellsQ35756979
Tumorigenic potential of extracellular matrix metalloproteinase inducerQ35842240
Pathways of apoptotic and non-apoptotic death in tumour cellsQ35852309
Paracrine induction of endothelium by tumor exosomes.Q35862798
The Trojan exosome hypothesisQ35976953
Extracellular vesicles from Paracoccidioides pathogenic species transport polysaccharide and expose ligands for DC-SIGN receptors.Q36099158
Extracellular Vesicles from Ovarian Carcinoma Cells Display Specific GlycosignaturesQ36139088
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupusQ36228965
Identification of a conserved glycan signature for microvesiclesQ36237543
A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280.Q36255171
Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cellsQ36265106
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylationQ36274919
Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migrationQ36293380
MicroRNAs are exported from malignant cells in customized particlesQ36305641
Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functionsQ36305646
Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic diseaseQ36355607
Chemotherapy-induced thrombosisQ36358511
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune diseaseQ36375982
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cellsQ36380062
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapyQ36558024
Tumour-derived exosomes and their role in cancer-associated T-cell signalling defectsQ36616153
Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentrationQ36621701
Phospholipid flippasesQ36665864
Extracellular vesicle isolation and characterization: toward clinical applicationQ36737951
Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatoryQ36796664
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.Q36821101
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activationQ36835483
The metastatic niche: adapting the foreign soilQ36928869
Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner.Q46033090
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophagesQ46219107
In vivo kinetic biodistribution of nano-sized outer membrane vesicles derived from bacteriaQ46842239
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology GroupQ46859424
Autoantigens are translocated into small apoptotic bodies during early stages of apoptosisQ46954138
Resolvins suppress tumor growth and enhance cancer therapy.Q47225724
Incidence of venous thromboembolism among chemotherapy-treated patients with lung cancer and its association with mortality: a retrospective database studyQ47772034
The biological significance of the thromboplastic protein of blood.Q47807987
Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism.Q47866335
Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cellsQ47872628
Role of Lymphocyte Subsets in the Immune Response to Primary B Cell-Derived Exosomes.Q47904335
Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cellsQ47915872
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle GenerationQ47969532
Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcomeQ48536084
Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: results of a record linkage studyQ48661559
Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cellsQ24307778
Calcium-dependent phospholipid scrambling by TMEM16FQ24308774
Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipidsQ24316767
Caspases: the executioners of apoptosisQ24530218
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersQ24614672
B lymphocytes secrete antigen-presenting vesiclesQ24678522
Apoptosis, oncosis, and necrosis. An overview of cell deathQ24684007
Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entryQ24794159
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trialQ24801506
Regulation of immune responses by extracellular vesiclesQ27006748
How apoptotic cells aid in the removal of their own cold dead bodiesQ27026126
Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytesQ27301739
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypesQ27317206
Wound repair: toward understanding and integration of single-cell and multicellular wound responsesQ36929762
Membrane protected apoptotic trophoblast microparticles contain nucleic acids: relevance to preeclampsiaQ37061065
Characterization of PKD protein-positive exosome-like vesiclesQ37086680
Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patientsQ37169096
Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapiesQ37179972
Chemotherapy-induced thrombosis: a role for microparticles and tissue factor?Q37223520
HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin.Q37267861
Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasisQ37341182
Tetraspanins: push and pull in suppressing and promoting metastasisQ37349647
Alternatively spliced tissue factor induces angiogenesis through integrin ligation.Q37429007
Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy.Q37438142
Chemotherapy-associated thrombosis.Q37450976
Exosome release by primary B cells.Q37524069
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesisQ37527786
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sortingQ37563470
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapseQ37629486
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and toleranceQ37659828
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stressQ37698517
Lectin microarrays for glycomic analysis.Q37781366
Macropinocytosis: an endocytic pathway for internalising large gulpsQ37855532
Exosome secretion: molecular mechanisms and roles in immune responsesQ37885448
The relationship between tissue factor and cancer progression: insights from bench and bedsideQ37953890
Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammationQ38062551
Tumour and microparticle tissue factor expression and cancer thrombosis.Q38067136
Extracellular vesicles as mediators of neuron-glia communicationQ38160219
Tetraspanin proteins promote multiple cancer stagesQ38186043
Tetraspanins in extracellular vesicle formation and functionQ38256370
Getting to know the extracellular vesicle glycome.Q38293737
Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesisQ38323182
Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.Q38335062
Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control studyQ38497226
An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure.Q38599462
ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbingQ38608946
Melanoma growth and lymph node metastasis is independent of host CD169 expressionQ38709566
Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years laterQ38760829
Extracellular vesicles and intercellular communication within the nervous systemQ38795618
Disassembly of the Dying: Mechanisms and Functions.Q38959192
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposureQ38987723
Methodological Guidelines to Study Extracellular VesiclesQ39299869
Antigen localization controls T cell-mediated tumor immunityQ39517776
Tumor apoptotic bodies inhibit CTL responses and antitumor immunity via membrane-bound transforming growth factor-beta1 inducing CD8+ T-cell anergy and CD4+ Tr1 cell responsesQ39793551
CD147 impacts angiogenesis and metastasis formation.Q39892358
Beta-2-glycoprotein 1-dependent macrophage uptake of apoptotic cells. Binding to lipoprotein receptor-related protein receptor family membersQ40036677
Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor modelQ40049073
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cellsQ40068378
Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation.Q40452110
Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.Q40503317
Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells--existence of a thresholdQ40653519
Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesiclesQ40801310
Dendritic cells acquire antigens from live cells for cross-presentation to CTL.Q40822225
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filamentsQ40895734
Involvement of FADD and caspase-8 signalling in detachment-induced apoptosisQ40925076
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLsQ41057373
Vesicles associated with calcification in the matrix of epiphyseal cartilageQ41112755
Tamoxifen induces TGF-beta 1 activity and apoptosis of human MCF-7 breast cancer cells in vitroQ41208987
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.Q41485418
Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation proceduresQ41607523
Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles.Q41820280
CD169 mediates the capture of exosomes in spleen and lymph node.Q41865373
Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17.Q41937849
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomesQ42112142
Oncosomes - large and small: what are they, where they came from?Q42390054
IgM promotes the clearance of small particles and apoptotic microparticles by macrophagesQ42702832
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulinQ43566795
Combination therapy with thalidomide plus dexamethasone for newly diagnosed myelomaQ44200289
A genomic perspective on membrane compartment organization.Q44883436
Histone chaperones in nucleosome assembly and human diseaseQ34647041
Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumorsQ34787754
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathwayQ34910947
The role of thrombospondin-1 in apoptosisQ34937276
Microvesicles: messengers and mediators of tumor progressionQ34987500
Surface glycosylation profiles of urine extracellular vesiclesQ34999330
Chemotherapeutic approaches for targeting cell death pathwaysQ35094229
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesiclesQ35148002
Cellular microparticles: what are they bad or good for?Q35181674
Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosisQ33181284
Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activationQ33379387
Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15RalphaQ33421740
Venous thrombosis: a multicausal diseaseQ33597786
Measurement of outward translocation of phospholipids across human erythrocyte membraneQ33647778
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applicationsQ33692926
Triggers, targets and treatments for thrombosisQ33765444
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselectionQ33850807
Horizontal transfer of DNA by the uptake of apoptotic bodies.Q33862992
Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model.Q33892712
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-primingQ33936302
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.Q33941102
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulationQ33956786
Cell biology. Eat me or die.Q33974281
Cancer, thrombosis, and anticoagulantsQ33982456
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesiclesQ34026858
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodiesQ34035888
Caspases: key players in programmed cell deathQ34103392
Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responsesQ34115645
Preparing the "soil": the premetastatic nicheQ34187595
Microparticles in cardiovascular diseases.Q34221054
Death by design: apoptosis, necrosis and autophagyQ34365753
Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distributionQ34441896
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular VesiclesQ34455456
Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseasesQ34463608
Processing of engulfed apoptotic bodies yields T cell epitopesQ34464645
RETRACTED: Pregnancy-associated exosomes and their modulation of T cell signalingQ34486229
SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactionsQ34518758
Lymphatic dissemination of tumour cells and the formation of micrometastasesQ34571762
Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserineQ34614956
Tumor-released microvesicles as vehicles of immunosuppression.Q34616014
Necrosis is an active and controlled form of programmed cell death.Q34628706
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
Membrane scission by the ESCRT-III complexQ27929846
alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cellsQ28142034
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINSQ28202269
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbingQ28210013
Complexes of tetraspanins with integrins: more than meets the eyeQ28210099
Double-stranded DNA in exosomes: a novel biomarker in cancer detectionQ28237711
Non-equilibration of hydrostatic pressure in blebbing cells.Q28251616
Role of platelet P-selectin and microparticle PSGL-1 in thrombus formationQ28254159
Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activityQ28255255
ExoCarta: A compendium of exosomal proteins and RNAQ28260686
Calreticulin exposure dictates the immunogenicity of cancer cell deathQ28280438
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammationQ28344659
Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2Q28348328
Resolution of lung inflammation by CD44Q28506254
Phosphatidylserine receptor is required for clearance of apoptotic cellsQ28513214
Sialoglycoproteins and N-glycans from secreted exosomes of ovarian carcinoma cellsQ28535417
Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependencyQ29032278
Caspases: enemies withinQ29547315
Exosomes: composition, biogenesis and functionQ29547721
Membrane vesicles as conveyors of immune responsesQ29547765
Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granulesQ29614240
A role for ubiquitin in selective autophagyQ29614499
Cellular senescence: when bad things happen to good cellsQ29615561
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Ceramide triggers budding of exosome vesicles into multivesicular endosomesQ29616811
Extracellular vesicles: exosomes, microvesicles, and friendsQ29618137
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomesQ29619437
Unexpected link between an antibiotic, pannexin channels and apoptosisQ30410630
Isolation and identification of potential urinary microparticle biomarkers of bladder cancerQ30445880
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentationQ30478057
Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic diseaseQ30494070
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodesQ30496134
ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasionQ30560783
Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.Q30805170
Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ERQ30826764
Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitroQ31090085
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectcellQ7868
apoptotic processQ14599311
neoplasmQ1216998
extracellular vesicleQ21097485
P304page(s)957
P577publication date2018-05-07
P1433published inFrontiers in ImmunologyQ27723748
P1476titleTumor-Derived Apoptotic Vesicles: With Death They Do Part.
P478volume9

Reverse relations

cites work (P2860)
Q60961340A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis
Q91707081Exosomes in cancer development, metastasis, and immunity
Q92988727Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination
Q64086001Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles
Q58738792Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?