Netrin-1 attracts axons through FAK-dependent mechanotransduction

scientific article

Netrin-1 attracts axons through FAK-dependent mechanotransduction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0999-12.2012
P932PMC publication ID3461192
P698PubMed publication ID22915102

P50authorMichael SheetzQ1929376
Simon W. MooreQ42559739
P2093author name stringXian Zhang
Christopher D Lynch
P2860cites workTyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesQ24306594
Deleted in Colorectal Cancer (DCC) encodes a netrin receptorQ24313278
DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1Q24336510
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcQ24614033
Signaling from axon guidance receptorsQ24633929
Structural basis for the autoinhibition of focal adhesion kinaseQ24678318
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptorsQ28118661
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparinQ28179787
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applicationsQ28213193
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) geneQ28236533
Mechanism of blebbistatin inhibition of myosin IIQ28267628
A novel Cas family member, HEPL, regulates FAK and cell spreadingQ28267647
Focal adhesion kinase in netrin-1 signalingQ28288747
Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfateQ28298433
Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout miceQ28506747
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IVQ28564388
Role of focal adhesion kinase in flow-induced dilation of coronary arteriolesQ28564649
p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinaseQ28572450
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansionQ28577458
Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeletonQ28581924
Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrixQ28583845
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasiaQ28585609
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylationQ28586815
Cellular Strategies of Axonal PathfindingQ29029769
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasQ29030077
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous systemQ29616040
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Cellular characterization of a novel focal adhesion kinase inhibitorQ30443304
Dynamic molecular processes mediate cellular mechanotransductionQ30453937
Talin depletion reveals independence of initial cell spreading from integrin activation and tractionQ30490335
Focal adhesion kinase is involved in mechanosensing during fibroblast migrationQ33944467
Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility.Q46125886
Netrins guide Drosophila commissural axons at short range.Q47070391
The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF.Q48087359
Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding.Q50715822
Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts.Q50740752
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complexQ58549456
A sensory role for neuronal growth cone filopodiaQ59067973
Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscleQ63385055
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strainQ71435733
Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1Q73754364
p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblastsQ78128211
Dissection and culture of embryonic spinal commissural neuronsQ81131068
The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domainQ84617570
Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidanceQ33996728
Netrins: versatile extracellular cues with diverse functionsQ34184016
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migrationQ34274897
The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegansQ34308728
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.Q34332258
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cordQ34332262
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attractionQ34360468
Activation of FAK and Src are receptor-proximal events required for netrin signalingQ34360478
Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkagesQ34415326
Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC.Q34451947
cAMP-dependent growth cone guidance by netrin-1.Q34451954
Direct evidence that growth cones pullQ34533657
Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.Q34559992
The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axonsQ34698265
Where the rubber meets the road: netrin expression and function in developing and adult nervous systemsQ35002876
Role of myosin II in axon outgrowth.Q35087189
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidanceQ35099606
p130CAS is required for netrin signaling and commissural axon guidanceQ36054147
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblastsQ36254663
Heparin/heparan sulphate binding in the TGF-beta cytokine superfamilyQ36482149
Proteoglycans as modulators of axon guidance cue function.Q36868917
Cell membrane mechanicsQ36888835
Netrins and their receptorsQ37082697
Focal adhesion kinase modulates cell adhesion strengthening via integrin activationQ37175419
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensingQ37779877
Biophysics of substrate interaction: influence on neural motility, differentiation, and repairQ37899109
Spatial and temporal regulation of focal adhesion kinase activity in living cells.Q40060648
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interactionQ40172193
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions.Q40676349
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).Q40716314
Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 proteinQ40796405
Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifsQ41334070
Axon initiation and growth cone turning on bound protein gradients.Q42455214
Traction on immobilized netrin-1 is sufficient to reorient axonsQ42559709
Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrixQ42824269
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesionQ43684842
Gene expression of EXT1 and EXT2 during mouse brain developmentQ44366919
Dual functional activity of semaphorin 3B is required for positioning the anterior commissureQ45345122
P4510describes a project that usesImageJQ1659584
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectmechanotransductionQ11936292
P304page(s)11574-11585
P577publication date2012-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleNetrin-1 attracts axons through FAK-dependent mechanotransduction
P478volume32

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cites work (P2860)
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Q45345116Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord
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